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Table 5 The PEDI and CP-QoL mean difference within-groups (from baseline) and difference between groups

From: The safety and efficacy of umbilical cord blood mononuclear cells in individuals with spastic cerebral palsy: a randomized double-blind sham-controlled clinical trial

 

Test of within-group effects mean change from baseline

Test of between-groups effects mean change

Control

MNC

 

MNC vs. control

Outcomes

Mean [95% CI]

Mean [95% CI]

β

[95% CI]

P.v

Cohen's d [95% CI]

PEDI Self-care

 T3

1.89 [0.16, 3.62]

3.63 [2.21, 5.04]a

1.74

[-1.48, 4.96]

0.290

0.28 [-0.20, 0.77]

 T4

0.15 [-1.63, 1.95]

3.79 [2.30, 5.28]

3.56

[0.69, 7.43]

0.018

0.73 [0.19, 1.26]

PEDI Mobility

 T3

0.13 [-1.69, 1.91]

2.57 [1.44, 3.69]

2.34

[-0.07, 5.02]

0.05

0.56 [-0.01, 1.10]

 T4

0.81 [-1.09, 2.72]

1.83 [0.65, 3.01]

1.52

[-1.14, 4.18]

0.31

0.62 [-0.25, 0.88]

PEDI Social function

 T3

3.04 [0.86, 5.23]

2.58 [-0.11, 5.27]

-0.44

[-4.14,3.26]

0.81

0.07 [-0.56, 0.41]

 T4

1.35 [-0.93, 3.60]

4.37 [1.53, 7.20]

3.09

[-0.76,6.96]

0.11

0.56 [-0.02, 1.08]

PEDI Total

 T3

5.09 [1.35, 8.83]

8.77 [4.76, 12.78]

3.73

[-4.07, 11.54]

0.348

0.40 [-0.13, 0.94]

 T4

1.58 [-2.30, 5.46]

9.95 [5.73, 14.17]

8.59

[0.44, 16.75]

0.039

0.78 [0.19, 1.37]

CPQoL

 Friends and family

  T3

-1.78 [-8.78,5.20]

3.21 [-3.16, 9.58]

5.24

[-3.71, 14.19]

0.251

0.24[-0.27, 0.75]

  T4

-10.36 [-17.45,-3.28]

-1.32 [-7.54, 4.88]

9.10

[0.20, 17.99]

0.045

0.63[0.10, 1.16]

 Participate in activities

  T3

-2.20 [-4.84, 0.43]

-1.62 [-6.25, -1.60]

0.59

[-3.14, 4.34]

0.755

0.10[-0.40,0.62]

  T4

-4.20 [-6.88,-1.53]

-2.23 [-4.63, 0.17]

3.93

[0.21, 7.65]

0.038

0.58[0.01,0.99]

 Communication

  T3

-2.65 [-4.42,-0.88]

-3.92 [-2.95, 0.59]

-1.26

[-4.17, 1.64]

0.394

0.26[-0.75,0.22]

  T4

-1.99 [-3.83,-0.15]

0.56 [-1.29, 2.43]

2.50

[-0.06, 5.17]

0.90

0.02 [-0.54,0.49]

 Physical health

  T3

-1.27 [-6.78,4.29]

0.42 [-8.24, 9.60]

2.52

[-7.75, 12.79]

0.630

0.07[-0.440.58]

  T4

-3.54[-9.12,2.02]

5.93 [-3.02, 14.88]

9.56

[-0.64, 19.77]

0.06

0.53 [0.01,1.05]

 Special equipment

  T3

-0.74 [-2.95,1.42]

0.18 [-2.11, 2.47]

0.85

[-2.30, 4.0]

0.597

0.08 [-0.43,0.59]

  T4

0.45 [-1.76, 2.67]

0.66 [-1.57, 2.90]

0.05

[-3.08, 3.19]

0.971

0.03[-0.47,0.54]

 Pain and impact of disability

  T3

-0.86 [-6.33,4.59]

-3.04 [-7.48, 1.40]

-2.41

[-9.27,4.46]

0.491

0.14 [-0.65,0.37]

  T4

1.31 [-4.22,6.58]

2.69 [-1.63, 7.02]

1.37

[-5.46, 8.20]

0.494

0.09[-0.41,0.60]

 Access to Services

  T3

-6.09 [-11.43,-0.74]

-2.66 [-9.52, 0.89]

3.71

[-4.45, 11.89]

0.372

0.22[-0.28,0.75]

  T4

-8.66 [-14.08,-3.24]

-5.28 [-11.42, 0.84]

3.39

[-4.72, 11.51]

0.412

0.19[-0.31,0.70]

 Family Health

  T3

-3.28 [-6.21,-0.35]

-3.47 [-5.88, -1.07]

-0.10

[-3.80, 3.59]

0.956

0.01 [-0.51,0.51]

  T4

-2.52 [-5.49,0.44]

-4.88 [-7.22, -2.54]

-2.42

[-6.10, 1.25]

0.196

0.24 [-0.76,0.26]

 CPQoL-total

  T3

-18.3 [-36.19,-0.37]

-8.42[-28.27, 11.41]

10.03

[-14.91, 34.97]

0.431

0.16[0.35, 0.67]

  sT4

-29.3 [-47.5, -11.2]

-5.33 [-24.66, 14.0]

24.08

[-0.70, 48.86]

0.057

0.46[-0.05, 0.98]

  1. aThe bold font shows that results are statistically significant
  2. CP-QoL Cerebral palsy quality of life child, PEDI Pediatric evaluation of disability inventory, T3 Six-month data collection, T4 One-year data collection