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Table 2 Neurologic characteristics of 53 patients with DPPX antibodies

From: Clinical and imaging analysis to evaluate the response of patients with anti-DPPX encephalitis to immunotherapy

 

No. (%)

 

Previous reported (n = 44)

Ours (n = 9)

Sum (n = 53)

Characteristics

 Cognitive disorders

32 (72.7)

7 (77.8)

39 (73.6)

 Brainstem or spinal cord disordersa

36 (81.8)

4 (44.4)

40 (75.5)

 Cerebellar ataxia

16 (36.4)

2 (22.2)

18 (34.0)

 Myoclonus or tremor

23 (52.3)

3 (33.3)

26 (49.1)

 Limb paralysis

0 (0)

2 (22.2)

2 (3.8)

 Psychosisb

14 (31.8)

1 (11.1)

15 (28.3)

 Headache

1 (2.3)

5 (55.6)

6 (11.3)

 Weight loss

25 (56.8)

3 (33.3)

28 (52.8)

 Sleep disordersc

17 (38.6)

4 (44.4)

21 (39.6)

 Mood disordersd

19 (43.2)

3 (33.3)

22 (41.5)

 Gastrointestinal symtomse

27 (61.4)

4 (44.4)

31 (58.5)

 Seizures

5 (11.4)

2 (22.2)

7 (12.2)

 Dysautonomiaf

17 (38.6)

3 (33.3)

20 (37.7)

 CSF elevated white cell account

16/33 (48.5)

2 (22.2)

18/42 (42.9)

 CSF elevated proteins

8/19 (42.1)

4 (44.4)

12/28 (42.9)

 Brain MRI abnormalities

9 (20.5)

8 (88.9)

17 (32.1)

 Brain MRI specific changes

1 (2.3)

7 (77.8)

8 (14.1)

 Tumor Screening

5 (11.4)

2 (22.2)

7 (13.2)

  1. Abbreviations: DPPX dipeptidyl-peptidase-like protein-6, MRI Magnetic Resonance Imaging
  2. a Abnormal eye movement; dysphagia; stiffness; dysarthria; respiratory failure; vertigo; hyperekplexia
  3. b Delirium; hallucination; delusion
  4. c Insomnia; hypersomnia; RBD
  5. d Depression; anxiety; apathy; appetite loss
  6. e Diarrhea; gastroparesis; constipation; abdominal pain
  7. f Diaphoresis; temperature dysregulation; urinary symptoms