Changes of biochemical biomarkers in the serum of children with convulsion status epilepticus: a prospective study

Table 4 Changes of serum biochemical biomarkers in children with CSE under the three etiological factors

Biomarkers	Seizure (day)	VEN (n = 13)	PGE (n = 30)	CFS (n = 14)
NSE	1	22.213 ± 4.663	21.152 ± 4.824	17.727 ± 6.29
(μg/l)	4	13.333 ± 3.107	9.228 ± 2.852^**	8.943 ± 3.140^**
(μg/l)	10	7.521 ± 1.765	6.637 ± 1.902	6.880 ± 2.252
S-100B	1	1.417 ± 0.151	0.528 ± 0.112^**	0.554 ± 0.112^**
(μg/l)	4	0.744 ± 0.173	0.398 ± 0.074^**	0.363 ± 0.384^**
(μg/l)	10	0.388 ± 0.051	0.360 ± 0.080	0.333 ± 0.066
CRP	1	14.727 ± 14.007	11.554 ± 13.448	6.871 ± 3.110
(mg/l)	4	3.668 ± 2.045	4.079 ± 2.364	2.547 ± 1.997
(mg/l)	10	4.917 ± 3.392	3.378 ± 2.285	2.722 ± 2.080
VEGF	1	168.428 ± 42.316	144.693 ± 27.884	158.529 ± 19.728
(ng/l)	4	159.401 ± 25.578	132.933 ± 21.607^*	131.167 ± 22.990^*
(ng/l)	10	117.093 ± 27.350	121.951 ± 58.054	121.146 ± 13.974
GFAP	1	2.751 ± 0.895	2.891 ± 1.348	2.756 ± 0.789
(ng/l)	4	3.693 ± 1.634	4.232 ± 1.189	3.782 ± 0.657
(ng/l)	10	2.892 ± 0.661	3.001 ± 0.912	2.755 ± 0.541

^*P < 0.05, **P < 0.01 vs. the VEN group. NSE neuron-specific enolase, VEGF vascular endothelial growth factor, S-100B S-100 calcium binding protein B, CRP C-reactive protein, GFAP glial fibrillary acidic protein, VEN viral encephalitis, PGE primary generalized epilepsy, CFS complex febrile seizures

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