Fig. 7

Blocking CDK5 can reduce the expression AT8 and reduce neuron death mediated by LPA. CCK-8 and TUNEL assays were used to determine the apoptosis of cortical neurons with or without CDK5 inhibitor (a-c). Immunofluorescence analysis of AT8 in neurons with or without CDK5 inhibitor (d). Data are presented as the mean ± S.E.M. from two independent cell experiments, *P < 0.05, **P < 0.01