Table 2 The detailed clinical information of 28 cases
From: Genetic origin of patients having spastic paraplegia with or without other neurologic manifestations
Case | Gender | Age/ AAO | Family history | Initial symptoms | Pure spastic paraplegia | Other symptoms | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hypertonia | Reflex | Pyramidal sign | Deep sensibility | Foot deformity | Cerebral Sign | Extra-pyramidal | Dementia | Dysarthria | Peripheral neuropathy | |||||
UL/LL | UL/LL | UL/LL | Â | Â | Â | Â | Â | Â | Â | |||||
1 | M | 18/12 | – | GD | −/+ | −/+ | −/+ | – | – | – | – | – | – | – |
2 | M | 24/20 | – | SL | −/+ | −/+ | −/+ | + | – | – | – | – | – | – |
3 | F | 14/4 | + | GD | −/+ | −/+ | −/+ | – | + | – | – | – | – | – |
4 | F | 13/3 | + | GD | −/+ | −/+ | −/+ | – | – | – | – | – | – | – |
5 | M | 43/13 | + | GD | −/+ | −/+ | −/+ | + | – | – | – | – | – | + |
6 | M | 31/24 | – | GD | −/+ | −/+ | −/+ | – | – | – | – | – | – | – |
7 | F | 47/27 | + | GD | −/+ | −/+ | −/+ | – | – | – | – | – | – | + |
8 | F | 62/32 | + | GD | −/+ | −/+ | −/+ | – | – | – | – | – | – | – |
9 | F | 44/4 | – | WL | −/+ | −/+ | −/+ | – | – | – | – | – | – | – |
10 | M | 14/4 | – | GD | −/+ | −/+ | −/+ | – | – | – | – | – | – | – |
11 | M | 21/17 | + | GI/WL | −/+ | −/+ | −/+ | – | + | – | – | – | – | – |
12 | F | 22/20 | – | GD | −/+ | −/+ | −/+ | – | – | + | – | – | – | + |
13 | M | 16/13 | U | GI/D | −/+ | +/+ | −/+ | + | – | + | – | + | + | – |
14 | F | 39/37 | – | WL | −/+ | +/+ | −/+ | + | – | – | – | – | + | – |
15 | M | 33/3 | – | GI | −/+ | +/+ | +/+ | + | + | + | – | – | + | – |
16 | F | 13/13 | + | GD | −/+ | −/+ | −/+ | – | + | + | – | + | + | + |
17 | M | 40/34 | – | GD | −/+ | −/+ | +/+ | – | – | – | – | – | – | + |
18 | M | 20/13 | – | GD | −/+ | +/+ | +/+ | – | – | – | – | – | – | – |
19 | M | 15/15 | – | GD | −/+ | −/+ | −/+ | – | + | – | – | – | – | – |
20 | M | 23/23 | – | WL | −/+ | −/+ | −/+ | – | + | – | – | – | – | + |
21 | F | 29/29 | – | GD | −/+ | +/+ | +/+ | – | – | – | – | – | – | – |
22 | M | 32/30 | + | GI/A | −/+ | +/+ | +/+ | – | – | – | – | + | + | – |
23 | M | 32/31 | – | WL | −/− | +/+ | +/+ | – | – | – | – | – | – | – |
24 | M | 24/24 | – | GD | −/+ | −/+ | −/+ | – | – | – | – | – | – | – |
25 | M | 68/61 | – | WL | −/+ | +/+ | +/+ | – | – | – | – | – | – | – |
26 | F | 30/13 | + | GI/A | −/+ | +/+ | +/+ | – | + | + | – | – | + | – |
27 | M | 23/3 | – | GI/A | −/+ | −/+ | +/+ | – | + | + | – | + | + | + |
28 | M | 14/12 | – | GD | −/+ | −/+ | −/+ | – | + | – | – | – | – | – |