Table 1 Demographic, disease, imaging and genetic characteristics of pre-FoG and non-FoG subjects at baseline
From: Predicting the onset of freezing of gait in Parkinson’s disease
Non-FoG (n = 115) | Pre-FoG (n = 68) | P | |
|---|---|---|---|
Demographic information | |||
Age (years) | 60.3 [52.8;68.5] | 64.9 [56.8;69.6] | 0.019* |
Age at Symptom Onset (years) | 58.6 [50.4;66.3] | 62.4 [55.3;68.3] | 0.009* |
Duration of Disease since Diagnosis (Months) | 3.87 [2.33;7.22] | 4.82 [2.46;7.02] | 0.606 |
Gender, female | 34 (29.6%) | 19 (27.9%) | 0.948 |
Years of education | 16.0 [14.0;18.0] | 16.0 [14.0;18.0] | 0.848 |
Family members with PD (any) | 27 (23.5%) | 19 (27.9%) | 0.620 |
Disease characteristics | |||
Side most affected at PD onset | 0.368 | ||
Left | 49 (42.6%) | 33 (48.5%) | |
Right | 65 (56.5%) | 33 (48.5%) | |
Symmetric | 1 (0.87%) | 2 (2.94%) | |
SPECT-DAT | |||
Mean caudate DAT uptake | 2.13 (0.49) | 1.90 (0.53) | 0.005* |
Mean putamen DAT uptake | 0.86 [0.70;1.03] | 0.74 [0.57;0.85] | 0.001* |
Mean striatum DAT uptake | 1.50 (0.35) | 1.33 (0.39) | 0.003* |
CSF biomarkers | |||
Abeta | 900 [704;1290] | 881 [622;1072] | 0.088 |
Tau | 165 [135;210] | 159 [140;200] | 0.659 |
pTau | 13.6 [11.2;17.2] | 13.9 [11.3;17.2] | 0.901 |
aSyn | 1462 [1121;1801] | 1423 [1141;1724] | 0.692 |
Genetic Pattern | |||
APOE | 0.938 | ||
e2/e2 | 1 (0.87%) | 0 (0.00%) | |
e2/e4 | 4 (3.48%) | 1 (1.47%) | |
e3/e2 | 13 (11.3%) | 10 (14.7%) | |
e3/e3 | 68 (59.1%) | 40 (58.8%) | |
e4/e3 | 26 (22.6%) | 16 (23.5%) | |
e4/e4 | 3 (2.61%) | 1 (1.47%) | |
SNCA_rs356181 | 0.414 | ||
C/C | 38 (33.0%) | 20 (29.4%) | |
C/T | 48 (41.7%) | 35 (51.5%) | |
T/T | 29 (25.2%) | 13 (19.1%) | |
SNCA_rs3910105 | 0.427 | ||
C/C | 20 (17.4%) | 8 (11.8%) | |
C/T | 60 (52.2%) | 34 (50.0%) | |
T/T | 35 (30.4%) | 26 (38.2%) | |
APOE Genotype—number of e4 alleles | 0.31 (0.52) | 0.28 (0.48) | 0.659 |
MAPT | 1.000 | ||
H1/H1 | 77 (67.0%) | 46 (67.6%) | |
H1/H2 | 32 (27.8%) | 19 (27.9%) | |
H2/H2 | 6 (5.22%) | 3 (4.41%) | |