Table 4 Pairwise comparison of outcome measures between different study time-points in the intervention group
Category | Time-point | Reference time-point | Mean Difference | Standard Error | P-value | 95% Confidence Interval for Difference |
|---|---|---|---|---|---|---|
Visual analog scale (headache severity) | 1 | 2 | 1.875 | 0.340 | < 0.001 | (1.150, 2.600) |
3 | 2.500 | 0.342 | < 0.001 | (1.772, 3.228) | ||
2 | 3 | 0.625 | 0.352 | 0.096 | (-0.125, 1.375) | |
Migraine disability assessment scale (MIDAS) | 1 | 2 | 21.875 | 4.513 | < 0.001 | (12.256, 31.494) |
3 | 23.813 | 4.841 | < 0.001 | (13.494, 34.131) | ||
2 | 3 | 1.938 | 0.692 | 0.013 | (0.462, 3.413) | |
MIDAS-A | 1 | 2 | 16.938 | 3.269 | < 0.001 | (9.970, 23.905) |
3 | 19.563 | 3.217 | < 0.001 | (12.705, 26.420) | ||
2 | 3 | 2.625 | 1.197 | 0.044 | (0.074, 5.176) | |
MIDAS-B | 1 | 2 | 1.594 | 0.369 | 0.001 | (0.808, 2.379) |
3 | 2.063 | 0.413 | < 0.001 | (1.182, 2.943) | ||
2 | 3 | 0.469 | 0.314 | 0.157 | (-0.202, 1.139) | |
Headache impact test (HIT) | 1 | 2 | 6.750 | 1.493 | < 0.001 | (3.568, 9.932) |
3 | 10.313 | 1.128 | < 0.001 | (7.908, 12.717) | ||
2 | 3 | 3.563 | 1.151 | 0.007 | (1.109, 6.016) | |
Hospital anxiety and depression scale-Anxiety | 1 | 2 | 2.625 | 0.774 | 0.004 | (0.975, 4.275) |
3 | 3.688 | 0.762 | < 0.001 | (2.063, 5.312) | ||
2 | 3 | 1.063 | 0.403 | 0.019 | (0.204, 1.921) | |
Hospital anxiety and depression scale-Depression | 1 | 2 | 2.063 | 0.433 | < 0.001 | (1.140, 2.985) |
3 | 2.313 | 0.561 | 0.001 | (1.118, 3.507) | ||
2 | 3 | 0.250 | 0.487 | 0.615 | (-0.789, 1.289) | |
Days with headache within the past 30 days | 1 | 2 | 5.625 | 1.179 | < 0.001 | (3.111, 8.139) |
3 | 8.125 | 1.541 | < 0.001 | (4.841, 11.409) | ||
2 | 3 | 2.500 | 1.114 | 0.040 | (0.125, 4.875) | |
Number of pain-relievers taken during the past 30 days | 1 | 2 | 7.188 | 1.085 | < 0.001 | (4.875, 9.500) |
3 | 8.688 | 1.413 | < 0.001 | (5.675, 11.700) | ||
2 | 3 | 1.500 | 0.764 | 0.068 | (-0.128, 3.128) |