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Fig. 1 | BMC Neurology

Fig. 1

From: Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis

Fig. 1

Clustered proteomic analysis of sera partially segregates ALS and control. A Cytometric bead array analysis of participant blood sera. IL-6, IL-8, RANTES, MCP-1, IP-10, fractalkine in control (n = 15) and ALS (n = 15) sera and sICAM-1 and sVCAM-1 in control (n = 8) and ALS (n = 8) sera. Boxes, 25th -75th percentiles; whiskers, minima and maxima. Statistical significance determined by Mann Whitney test. B Proteome profiler analysis of an extended panel of 105 cytokines in control (n = 6) and ALS (n = 6) participant blood sera. Raw intensity normalized to reference spot intensity of each membrane. Proteins (n = 20) with the greatest difference between ALS/controls shown. Boxes, 25th -75th percentiles; whiskers, minima and maxima. Statistical analysis determined by Mann-Whitney test. C Heat map shows unsupervised hierarchical clustering of the listed cytokines. D Unsupervised hierarchical clustering of growth factors BDNF, EGF and PDGF-AB/BB/AA

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BMC Neurology

ISSN: 1471-2377

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