Table 2 Logistic regression analysis taking into account clinical factors and biomarkers. Dependent variable: Wake-up IS
From: Surrogate biomarkers of outcome for wake-up ischemic stroke
Model A | ||||||
Independent variables | Not adjusted | Adjusted | ||||
OR | CI 95% | p value | OR | CI 95% | p value | |
Age | 1.01 | 1.00–1.00 | 0.003 | 0.99 | 0.98–1.01 | 0.879 |
Previous mRS | 1.40 | 1.20–1.63 | < 0.0001 | 1.25 | 1.00–1.56 | 0.049 |
Hyperlipidemia | 1.29 | 1.05–1.59 | 0.017 | 1.19 | 0.89–1.57 | 0.226 |
Atrial fibrillation | 1.37 | 1.08–1.73 | 0.008 | 1.06 | 0.72–1.55 | 0.783 |
Anticoagulants | 1.74 | 1.27–2.39 | 0.001 | 1.29 | 0.78–2.13 | 0.325 |
Temperature | 2.46 | 2.13–2.84 | < 0.0001 | 2.15 | 1.77–2.61 | < 0.0001 |
Leukocytes | 1.09 | 1.06–1.12 | < 0.0001 | 1.00 | 0.96–1.05 | 0.919 |
Fibrinogen | 1.00 | 1.00–1.00 | 0.001 | 0.99 | 0.99–1.00 | 0.013 |
C-reactive protein | 1.13 | 1.11–1.16 | < 0.0001 | 1.14 | 1.01–1.17 | < 0.0001 |
Erythrocyte sedimentation rate | 1.01 | 1.00–1.02 | < 0.0001 | 1.00 | 0.99–1.00 | 0.688 |
NIHSS at admission | 1.02 | 1.00–1.03 | 0.009 | 0.99 | 0.98–1.02 | 0.642 |
Systemic fibrinolytic treatment | 0.43 | 0.32–0.58 | < 0.0001 | 0.36 | 0.24–0.54 | < 0.0001 |
NT-proBNP levels | 1.00 | 1.00–1.00 | 0.005 | 1.00 | 1.00–1.00 | 0.172 |
25-Hydroxy-Vitamin D at 24 h | 0.69 | 0.66–0.74 | < 0.0001 | 0.75 | 0.71–0.79 | < 0.0001 |
Model B | ||||||
Independent variables | Not adjusted | Adjusted | ||||
OR | CI 95% | p value | OR | CI 95% | p value | |
Age | 1.01 | 1.00–1.00 | 0.003 | 0.98 | 0.96–1.04 | 0.913 |
Previous mRS | 1.40 | 1.20–1.63 | < 0.0001 | 1.22 | 0.99–2.13 | 0.108 |
Hyperlipidemia | 1.29 | 1.05–1.59 | 0.017 | 1.24 | 0.68–1.85 | 0.318 |
Atrial fibrillation | 1.37 | 1.08–1.73 | 0.008 | 1.09 | 0.70–1.61 | 0.719 |
Anticoagulants | 1.74 | 1.27–2.39 | 0.001 | 1.27 | 0.67–2.88 | 0.403 |
Temperature | 2.46 | 2.13–2.84 | < 0.0001 | 1.87 | 1.21–3.15 | 0.048 |
Leukocytes | 1.09 | 1.06–1.12 | < 0.0001 | 1.00 | 0.82–1.13 | 0.806 |
Fibrinogen | 1.00 | 1.00–1.00 | 0.001 | 1.01 | 0.86–1.78 | 0.162 |
C-reactive protein | 1.13 | 1.11–1.16 | < 0.0001 | 1.13 | 0.99–1.32 | 0.089 |
Erythrocyte sedimentation rate | 1.01 | 1.00–1.02 | < 0.0001 | 0.99 | 0.72–1.35 | 0.544 |
NIHSS at admission | 1.02 | 1.00–1.03 | 0.009 | 0.99 | 0.99–1.06 | 0.405 |
Systemic fibrinolytic treatment | 0.43 | 0.32–0.58 | < 0.0001 | 0.67 | 0.35–0.83 | 0.018 |
NT-proBNP levels | 1.00 | 1.00–1.00 | 0.005 | 1.00 | 1.00–1.00 | 0.172 |
IL-6 levels at admission | 1.12 | 1.04–1.21 | 0.003 | 1.10 | 1.04–1.18 | 0.002 |
25-Hydroxy-Vitamin D at 24 h | 0.69 | 0.66–0.74 | < 0.0001 | 0.85 | 0.71–1.03 | 0.089 |