Table 3 Trend of the headache days by the duration of onabotulinumtoxin150 units therapy
From: OnabotulinumtoxinA in chronic migraine: is the response dose dependent?
Number of the headache days | Number of the severe headache days | |
|---|---|---|
Patients who just had 3 rounds of onabotulinumtoxinA 150 units before the increase to 200 units (n = 22) | ||
Baseline (36 weeks before the increase) | 25.86 ± 5.45 | 13.73 ± 8.54 |
24 weeks before the increase | 19.41 ± 9.49 | 8.59 ± 9.11 |
12 weeks before the increase | 17.40 ± 11.13 | 7.27 ± 9.15 |
Day of increase to 200 Units | 15.95 ± 11.02 | 6.59 ± 6.90 |
12 weeks after the increase | 15.09 ± 12.09 | 4.23 ± 5.77 |
24 weeks after the increase | 13.59 ± 10.89 | 4.27 ± 3.99 |
36 weeks after the increase | 14.77 ± 11.53 | 4.86 ± 4.11 |
Patients who had less than 8 rounds of onabotulinumtoxinA 150 units before the increase to 200 units (n = 92) | ||
Baseline | 24.84 ± 6.13 | 14.26 ± 8.38 |
36 weeks before the increase | 17.54 ± 10.90 | 6.92 ± 7.07 |
24 weeks before the increase | 15.58 ± 11.53 | 5.74 ± 7.13 |
12 weeks before the increase | 14.89 ± 11.22 | 5.08 ± 6.42 |
Day of increase to 200 units | 14.36 ± 11.64 | 5.17 ± 5.92 |
12 weeks after the increase | 12.86 ± 11.36 | 4.10 ± 4.90 |
24 weeks after the increase | 12.81 ± 11.36 | 3.47 ± 4.11 ** |
36 weeks after the increase | 11.79 ± 11.47 * | 3.83 ± 4.32 ** |
Patients who had at least 8 rounds of onabotulinumtoxinA 150 units before the increase to 200 units (n = 83) | ||
Baseline | 26.97 ± 5.04 | 16.25 ± 7.36 |
36 weeks before the increase | 10.53 ± 9.48 | 4.72 ± 6.34 |
24 weeks before the increase | 11.37 ± 9.77 | 5.16 ± 6.33 |
12 weeks before the increase | 12.40 ± 9.93 | 5.59 ± 6.59 |
Day of increase to 200 units | 12.79 ± 9.77 | 6.67 ± 7.48 |
12 weeks after the increase | 10.79 ± 9.52 * | 4.59 ± 5.59 ** |
24 weeks after the increase | 11.90 ± 9.94 | 4.23 ± 5.76 *** |
36 weeks after the increase | 10.16 ± 9.57 ** | 4.22 ± 5.47 ** |