From: OnabotulinumtoxinA in chronic migraine: is the response dose dependent?
Number of the headache days | Number of the severe headache days | |
---|---|---|
Patients who were followed for at least 60 weeks after the increase in onabotulinumtoxinA dose (n = 117) | ||
Baseline | 26.23 ± 5.63 | 15.31 ± 7.83 |
36 weeks before the increase | 13.89 ± 10.69 | 5.37 ± 6.01 |
24 weeks before the increase | 13.35 ± 10.41 | 5.34 ± 6.40 |
12 weeks before the increase | 13.56 ± 10.39 | 4.99 ± 6.27 |
Day of increase to 200 units | 13.40 ± 10.37 | 5.28 ± 6.03 |
12 weeks after the increase | 12.07 ± 10.40 | 4.47 ± 5.69 |
24 weeks after the increase | 13.18 ± 10.77 | 3.80 ± 4.98 ** |
36 weeks after the increase | 11.14 ± 10.48 ** | 3.67 ± 4.82 *** |
48 weeks after the increase | 12.12 ± 10.70 | 4.02 ± 5.51 * |
60 weeks after the increase | 10.51 ± 9.74 *** | 3.55 ± 4.93 *** |
Patients who were followed for at least 84 weeks after the increase in onabotulinumtoxinA dose (n = 51) | ||
Baseline | 27.21 ± 4.86 | 17.08 ± 7.87 |
36 weeks before the increase | 13.29 ± 10.78 | 5.08 ± 5.47 |
24 weeks before the increase | 14.33 ± 10.55 | 6.18 ± 6.89 |
12 weeks before the increase | 13.61 ± 10.70 | 5.37 ± 6.08 |
Day of increase to 200 units | 14.59 ± 10.63 | 5.00 ± 5.84 |
12 weeks after the increase | 13.67 ± 10.81 | 4.78 ± 5.75 |
24 weeks after the increase | 14.84 ± 10.73 | 3.63 ± 4.27 |
36 weeks after the increase | 11.41 ± 10.51 * | 3.61 ± 4.39 * |
48 weeks after the increase | 13.49 ± 11.13 | 3.57 ± 3.53 |
60 weeks after the increase | 10.12 ± 9.70 ** | 3.92 ± 5.09 |
72 weeks after the increase | 11.72 ± 10.84 | 3.84 ± 4.69 |
84 weeks after the increase | 10.21 ± 9.19 ** | 3.16 ± 4.04 * |