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Table 4 Trend of the headache days in patients who were followed for over 36 weeks after the increase in the onabotulinumtoxinA dose

From: OnabotulinumtoxinA in chronic migraine: is the response dose dependent?

 

Number of the headache days

Number of the severe headache days

Patients who were followed for at least 60 weeks after the increase in onabotulinumtoxinA dose (n = 117)

 Baseline

26.23 ± 5.63

15.31 ± 7.83

 36 weeks before the increase

13.89 ± 10.69

5.37 ± 6.01

 24 weeks before the increase

13.35 ± 10.41

5.34 ± 6.40

 12 weeks before the increase

13.56 ± 10.39

4.99 ± 6.27

 Day of increase to 200 units

13.40 ± 10.37

5.28 ± 6.03

 12 weeks after the increase

12.07 ± 10.40

4.47 ± 5.69

 24 weeks after the increase

13.18 ± 10.77

3.80 ± 4.98 **

 36 weeks after the increase

11.14 ± 10.48 **

3.67 ± 4.82 ***

 48 weeks after the increase

12.12 ± 10.70

4.02 ± 5.51 *

 60 weeks after the increase

10.51 ± 9.74 ***

3.55 ± 4.93 ***

Patients who were followed for at least 84 weeks after the increase in onabotulinumtoxinA dose (n = 51)

 Baseline

27.21 ± 4.86

17.08 ± 7.87

 36 weeks before the increase

13.29 ± 10.78

5.08 ± 5.47

 24 weeks before the increase

14.33 ± 10.55

6.18 ± 6.89

 12 weeks before the increase

13.61 ± 10.70

5.37 ± 6.08

 Day of increase to 200 units

14.59 ± 10.63

5.00 ± 5.84

 12 weeks after the increase

13.67 ± 10.81

4.78 ± 5.75

 24 weeks after the increase

14.84 ± 10.73

3.63 ± 4.27

 36 weeks after the increase

11.41 ± 10.51 *

3.61 ± 4.39 *

 48 weeks after the increase

13.49 ± 11.13

3.57 ± 3.53

 60 weeks after the increase

10.12 ± 9.70 **

3.92 ± 5.09

 72 weeks after the increase

11.72 ± 10.84

3.84 ± 4.69

 84 weeks after the increase

10.21 ± 9.19 **

3.16 ± 4.04 *

  1. Data presented as mean ± SD; * P < 0.05, ** P < 0.01, *** P < 0.001 for the paired t-test compared to the day of increase to 200 units