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Table 7 Trend of the wearing off periods after increase in the onabotulinumtoxinA dose. (n = 113)

From: OnabotulinumtoxinA in chronic migraine: is the response dose dependent?

 

Wearing off period, days

36 weeks before the increase

16.11 ± 9.11

24 weeks before the increase

15.67 ± 11.08

12 weeks before the increase

16.54 ± 11.94

Day of increase to 200 Units

16.91 ± 10.36

12 weeks after the increase

14.00 ± 10.75 *

24 weeks after the increase

13.26 ± 9.13 **

36 weeks after the increase

14.68 ± 9.21 *

  1. Data presented as mean ± SD; * P < 0.05, ** P < 0.01 for the paired t-test compared to the day of increase to 200 units