Skip to main content

Table 2 Univariable logistic regression analyses between possible factors and EPVS of three locations in the brain

From: Homocysteine is related to enlarged perivascular spaces in the brainstem in patients with isolated pontine infarction

Factors

moderate to severe BG-EPVS

moderate to severe CSO-EPVS

brainstem-EPVS

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

Sex, male

0.921 (0.537-1.578)

0.763

1.005 (0.591-1.707)

0.986

0.700 (0.406-1.206)

0.199

Age

1.057 (1.024-1.091)

0.001*

0.988 (0.960-1.016)

0.390

1.020 (0.991-1.050)

0.172

Body Mass Index

0.959 (0.869-1.057)

0.397

1.034 (0.940-1.138)

0.489

0.961 (0.871-1.060)

0.427

Hypertension

1.658 (0.613-4.488)

0.319

1.202 (0.480-3.011)

0.694

0.515 (0.205-1.299)

0.160

SBP

1.010 (0.997-1.024)

0.124

0.998 (0.985-1.011)

0.766

1.001 (0.988-1.014)

0.875

DBP

0.983 (0.958-1.008)

0.182

0.988 (0.964-1.013)

0.349

0.988 (0.963-1.013)

0.347

Diabetes

1.138 (0.655-1.978)

0.646

1.077 (0.627-1.852)

0.788

0.807 (0.466-1.397)

0.443

FPG

0.927 (0.842-1.022)

0.127

0.995 (0.909-1.089)

0.916

1.022 (0.932-1.120)

0.646

HbA1c

0.935 (0.828-1.057)

0.283

1.013 (0.901-1.140)

0.829

1.010 (0.896-1.138)

0.872

Hyperlipidemia

0.662 (0.373-1.174)

0.158

0.765 (0.440-1.330)

0.342

1.154 (0.658-2.023)

0.618

Total cholesterol

0.745 (0.567-0.980)

0.035*

0.902 (0.698-1.165)

0.427

1.134 (0.875-1.471)

0.341

Triglyceride

0.708 (0.529-0.946)

0.020*

0.896 (0.721-1.115)

0.326

0.845 (0.661-1.081)

0.179

HDL-C

1.634 (0.592-4.510)

0.343

1.347 (0.491-3.696)

0.562

2.591 (0.923-7.276)

0.071

LDL-C

0.697 (0.486-1.000)

0.050

0.997 (0.709-1.404)

0.988

1.239 (0.875-1.756)

0.227

Ischemic stroke or TIA history

2.130 (1.133-4.005)

0.019*

1.573 (0.829-2.984)

0.165

3.340 (1.747-6.386)

<0.001*

Coronary heart disease

1.307 (0.457-3.739)

0.617

1.289 (0.443-3.751)

0.641

0.996 (0.342-2.901)

0.994

Current smoking

0.749 (0.429-1.306)

0.308

1.168 (0.678-2.012)

0.575

1.341 (0.774-2.321)

0.295

Alcohol use

1.001 (0.488-2.050)

0.999

1.292 (0.632-2.643)

0.482

1.972 (0.969-4.012)

0.061

Fibrinogen

1.187 (0.819-1.719)

0.365

0.989 (0.686-1.425)

0.952

1.407 (0.967-2.048)

0.075

CCrE

0.982 (0.970-0.995)

0.006*

1.009 (0.997-1.022)

0.141

0.987 (0.974-0.999)

0.036*

Uric acid

1.000 (0.997-1.003)

0.881

1.001 (0.998-1.004)

0.634

1.004 (1.001-1.007)

0.019*

tHcy

1.047 (1.015-1.079)

0.003*

0.996 (0.971-1.022)

0.773

1.104 (1.057-1.152)

<0.001*

WMH grade

1.48 (1.210-1.811)

<0.001*

1.063 (0.884-1.278)

0.519

1.223 (1.012-1.477)

0.037*

Lacunes

1.632 (0.950-2.804)

0.076

1.352 (0.798-2.289)

0.262

1.844 (1.068-3.183)

0.028*

IPI classification

1.089 (0.603-1.966)

0.778

1.379 (0.772-2.463)

0.277

0.810 (0.451-1.455)

0.481

  1. Abbreviations: tHcy total homocysteine, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c glycosylated hemoglobin, TIA transient ischemic attack, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, CCrE estimated creatinine clearance, IPI isolated pontine infarction, PPI paramedian pontine infarction, SDPI small deep pontine infarction, WMH white matter hyperintensities, EPVS enlarged perivascular spaces, CSO the centrum semiovale, BG the basal ganglia, OR odds ratio, CI confidence interval
  2. WMH grade was assessed on T2FLAIR sequences with the Fazekas scale ranging from 0-6
  3. * P < 0.05
Back to article page

BMC Neurology

ISSN: 1471-2377

Contact us