Homocysteine is related to enlarged perivascular spaces in the brainstem in patients with isolated pontine infarction

Table 3 Multivariable logistic regression analyses between possible factors and BG-/brainstem-EPVS

Factors	moderate to severe BG-EPVS ^a		brainstem-EPVS ^b
Factors	adjusted OR (95% CI)	P value	adjusted OR (95% CI)	P value
Age	1.033 (0.988-1.079)	0.153	—	—
Total cholesterol	0.782 (0.566-1.080)	0.135	—	—
Triglyceride	0.818 (0.601-1.112)	0.200	—	—
Ischemic stroke or TIA history	1.814 (0.897-3.667)	0.097	2.874 (1.402-5.891)	0.004*
CCrE	0.996 (0.979-1.013)	0.629	0.995 (0.981-1.009)	0.488
Uric acid	—	—	1.003 (0.999-1.006)	0.150
tHcy	1.048 (1.016-1.082)	0.003*	1.099 (1.051-1.149)	<0.001*
WMH grade	1.380 (1.103-1.727)	0.005*	1.213 (0.973-1.513)	0.087
Lacunes	—	—	1.306 (0.691-2.471)	0.411

Abbreviations: tHcy total homocysteine, TIA transient ischemic attack, CCrE estimated creatinine clearance, WMH white matter hyperintensities, EPVS enlarged perivascular spaces, BG the basal ganglia, OR odds ratio, CI confidence interval
^a Adjusted with P < 0.05 in the univariable analysis (age, total cholesterol, triglyceride, ischemic stroke or TIA history, CCrE, and WMH grade)
^b Adjusted with P < 0.05 in the univariable analysis (ischemic stroke or TIA history, CCrE, uric acid, WMH grade, and lacunes of presumed vascular origin)
* P < 0.05

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