Brain structural and functional connectivity alterations are associated with fatigue in neuromyelitis optica spectrum disorder

Table 2 Comparisons of volumes of deep gray matter between each patient subgroup and healthy controls, corrected by the eTIV provided by the Freesurfer pipeline

Anatomical structures		Healthy controls	Low fatigue	High fatigue	p value
Caudate nucleus	Left	0.2435 ± 0.0230	0.2458 ± 0.0278	0.2441 ± 0.0161	0.951
	Right	0.2530 ± 0.0235	0.2556 ± 0.0304	0.2542 ± 0.0199	0.952
Putamen	Left	0.3562 ± 0.0271	0.3584 ± 0.0547	0.3550 ± 0.0481	0.974
	Right	0.3507 ± 0.0275	0.3669 ± 0.0489	0.3420 ± 0.0465	0.219
Pallidum	Left	0.1372 ± 0.0145	0.1454 ± 0.0193	0.1573 ± 0.0214	0.008
	Right	0.1302 ± 0.0145	0.1426 ± 0.0153	0.1466 ± 0.0238	0.022
Amygdala	Left	0.1105 ± 0.0131	0.1078 ± 0.0170	0.1103 ± 0.0125	0.829
	Right	0.1239 ± 0.0083	0.1209 ± 0.0169	0.1207 ± 0.0126	0.705
Hippocampus	Left	0.2868 ± 0.0224	0.2844 ± 0.0183	0.2848 ± 0.0245	0.935
	Right	0.2959 ± 0.0230	0.2932 ± 0.0209	0.2899 ± 0.0284	0.763
Nucleus accumbens	Left	0.0417 ± 0.0052	0.0377 ± 0.0052	0.0361 ± 0.0071	0.017
	Right	0.0372 ± 0.0033	0.0369 ± 0.0056	0.0357 ± 0.0053	0.625
Thalamus proper	Left	0.4974 ± 0.0376	0.5133 ± 0.0606	0.4814 ± 0.0581	0.225
	Right	0.4707 ± 0.0326	0.4840 ± 0.0395	0.4616 ± 0.0482	0.276

Values are mean ± SD of corrected volumes (structure volume / eTIV × 100). eTIV estimated intracranial volume

ISSN: 1471-2377