Fig. 1

Study Design and Procedures. Patients received LEV during a perioperative period of nine days. Levetiracetam plasma levels were measured two days after onset of LEV administration and three days postoperative. Hematotoxicity was measured through blood samples one week after surgery. Neuropsychological assessment (NeuroCogFX), including HRQoL questionnaire (QOLIE-31) and self-reported side effects, was conducted at four timepoints: one day before administration of levetiracetam (Baseline/no LEV), on the second day after onset of levetiracetam administration (Pre-Op/with LEV), four to six days after surgery (Post-Op/with LEV) and three weeks after surgery (Follow-Up/no LEV). The total study duration was 25 days