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Fig. 3 | BMC Neurology

Fig. 3

From: Perioperative levetiracetam for seizure prophylaxis in seizure-naive brain tumor patients with focus on neurocognitive functioning

Fig. 3

(A) Estimated marginal means and corresponding standard error bars in standard value points across the four timepoints for the cognitive domain scores and Total score. Neuropsychological assessment of cognitive functioning was measured at four timepoints (Fig. 1). Total Score consists of the following domains: attention, working memory, memory and language. Which subtests constitute domains, see methods section. (B) Estimated marginal mean differences and corresponding 95%, Bonferroni adjusted confidence intervals of standard value points for cognitive domain scores and Total score between Pre-Op and Baseline testing. Cognitive functioning at Baseline (no levetiracetam) was measured one day before administration of levetiracetam and at Pre-Op (with levetiracetam) on the third day after onset of levetiracetam administration. Vertical dotted line represents the clinically meaningful deterioration margin. Bonferroni adjustment was made for six pairwise comparisons. Total Score consists of the domain attention, working memory, memory, and language. Which subtests constitute domains, see methods section

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