Fig. 1

Brain (A-L) and muscle MRI (M, N) findings. Brain MRI revealed bilateral subcortical high-intensity lesions in the centrum semiovale and anterior and posterior horns of the lateral ventricle on T2WI (D, E, F) and FLAlR (G, H, I) images. The corresponding lesions were characterized by high signal intensity on DWI sequences (J, K, L). Muscle MRI showed fatty infiltration and the atrophy of the lower limb muscles. The distal muscles (N calf level) were more severely affected than the proximal muscles (M thigh level), and the posterior muscles were more severely affected than the anterior muscles