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Fig. 2 | BMC Neurology

Fig. 2

From: NOTCH2NLC-related oculopharyngodistal myopathy type 3 complicated with focal segmental glomerular sclerosis: a case report

Fig. 2

Pathological changes in the skin, muscle, and kidney biopsy samples. Cells were imaged with an Olympus BX51 microscope with a DP72 camera and the Plan achromat objective, and images were acquired by CellSens software. For electron microscopy, cells were observed with a transmission electron microscope (TEM, JEM 1230, JEOL) with a CCD electronic imaging system, and images were acquired by Gatan Digital Micrograph software. A Immunohistochemical staining showed that the inclusion bodies in the skin biopsy sample were positive for p62 (bar = 20 μm, 1000 ×). B, C Rimmed vacuoles were present in the muscle fibres of mGT and H&E stained Sects. (400 × bar = 50 μm). D, E Renal pathological characteristics in PASM plus Masson stained sections (In D, bar = 50 μm, 400 × ; In E, bar = 100 μm, 200 ×). The arrow in (D) shows segmental sclerosis. The arrow in (E) shows the localized tubular atrophy. F H&E staining of renal tubular epithelial cells (bar = 20 μm, 1000 ×). The arrow indicates eosinophilic inclusion bodies. G Electron microscopy of renal tissues demonstrated intranuclear inclusions without membranes (bar = 1 μm, 10 K ×) (marked by arrow and shown at higher magnification)

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