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Table 3 Subgroup analyses of the relationship between ALP quintiles (Q1-Q5) and poor 3-month prognosis in AIS patients with preserved renal function

From: Relationship between serum alkaline phosphatase and poor 3-month prognosis in acute ischemic stroke patients with preserved renal function: results from Xi’an Stroke Registry Study of China

Confounding factor category

ALP level quintiles(Q1-Q5)

P for trend

P for interaction

Q1

Q2

Q3

Q4

Q5

Age, years

      

0.188

  < 65

2.28(0.69 ~ 7.52)

3.39(1.03 ~ 11.1)

5.33(1.76 ~ 16.16)

Reference

4.78(1.59 ~ 14.33)

0.434

 

  ≥ 65

1.34(0.75 ~ 2.42)

1.41(0.78 ~ 2.56)

1.29(0.71 ~ 2.36)

Reference

1.43(0.79 ~ 2.61)

0.721

 

Sex

      

0.243

 man

1.83(0.89 ~ 3.76)

2.39(1.17 ~ 4.87)

2.83(1.39 ~ 5.77)

Reference

2.24(1.07 ~ 4.67)

0.620

 

 women

1.49(0.68 ~ 3.27)

1.24(0.55 ~ 2.79)

1.03(0.48 ~ 2.18)

Reference

1.63(0.81 ~ 3.29)

0.835

 

Drinking

      

0.851

 yes

1.55(0.88 ~ 2.71)

1.8(1.02 ~ 3.18)

1.76(1.01 ~ 3.07)

Reference

1.97(1.15 ~ 3.38)

0.979

 

 no

1.19(0.32 ~ 4.42)

1.37(0.39 ~ 4.86)

1.94(0.56 ~ 6.68)

Reference

1.05(0.26 ~ 4.32)

0.699

 

Hypertension

      

0.647

 yes

1.86(0.72 ~ 4.82)

1.75(0.68 ~ 4.55)

1.62(0.62 ~ 4.24)

Reference

1.87(0.72 ~ 4.86)

0.646

 

 no

1.29(0.69 ~ 2.4)

1.55(0.83 ~ 2.89)

1.82(1 ~ 3.29)

Reference

1.78(0.99 ~ 3.22)

0.696

 

Leukocyte count, × 109/L

      

0.720

  < 10

1.71(0.98 ~ 2.99)

1.9(1.08 ~ 3.35)

1.94(1.12 ~ 3.37)

Reference

1.99(1.14 ~ 3.45)

0.683

 

  ≥ 10

0.91(0.14 ~ 5.82)

1.13(0.2 ~ 6.44)

2.04(0.34 ~ 12.03)

Reference

2.24(0.52 ~ 9.66)

0.455

 
  1. Notes: adjusted for smoking, prior stroke, NIHSS score at admission, BMI, serum creatinine, eGFR; Pneumonia during hospitalization, atrial fibrillation, diabetes mellitus, ALT,
  2. Abbreviations: ALP Alkaline phosphatase, eGFR estimated glomerular filtration rate, OR Odds ratios, CI Confidence interval, Q Quintiles
  3. Q1: < 58.8 U/L, Q2: 58.8–69.5 U/L, Q3: 69.6–81.6 U/L, Q4: 81.7–97.5 U/L, Q5: ≥ 97.6 U/L