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Table 1 HeMoVal study assessment table. Overview of the different study periods (enrollment, baseline assessment, monitoring, 3-months follow-up, measurements) with the corresponding time schedule and assessments

From: The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury

Study periods

Enrollment

Baseline assessment

Monitoring

3-months follow-up

Measurements

Time

Hospital admission

Study inclusion

Daily after inclusion for max. 14 days postSAH

+ 12 weeks after event (+/− 2 weeks)

N/A

Eligibility Criteria

x

    

Patient information & consenting

x

    

Demographic/baseline measures

 

x

   

CSF-sampling

  

x (daily, if EVD/LD)

  

aVSP

  

x (daily, if imaging)

  

DCI

  

x (daily, if imaging)

  

DIND

  

x (daily, if assessable)

  

Spasmolysis

  

x (daily)

  

Intracerebroventricular rtPA

  

x (daily)

  

Triple H therapy

  

x (daily)

  

Surgical decompression

  

x (daily)

  

Nimodipine therapy

  

x (daily)

  

CSF infection

  

x (daily)

  

Surgical site infection

  

x (daily)

  

Chronic hydrocephalus

   

x

 

GOSE

   

x

 

mRS

   

x

 

Hematoma volume

    

x

CSF-Hb

    

x