Fig. 1

Pedigree diagram and brain computed tomography (CT). A Pedigree of the family with primary familial brain calcification (PFBC). The proband is indicated by an arrow. The black shaded symbols indicate the symptomatic patients with PFBC. The grey shaded symbols indicate the asymptomatic patients with PFBC. B Patient II: 4, brain CT showed calcification in the cerebellum, basal ganglia, subcortical and deep white matter. C Patient I: 1, brain CT showed calcification in the basal ganglia, white matter adjacent to the lateral ventricle and subcortical white matter. D Patient III: 1, brain CT showed calcification in the basal ganglia and subcortical white matter. E-F Patient II: 1 and patient III: 5, brain CT showed symmetrical calcification only in the bilateral basal ganglia. G Patient III: 3, brain CT showed mild unsymmetrical scattered punctate calcifications only in the basal ganglia (arrows)