Table 1 Therapeutic regimens in three groups
Variables | Group I (n = 49) | Group II(n = 71) | Group III(n = 28) | P-value |
|---|---|---|---|---|
The average daily dosages of AMB, mean ± SD, mg/kg/d | 0.64 ± 0.14 | 0.60 ± 0.13 | 0.55 ± 0.15 | 0.023* |
The lengths of AMB, median (IQR), days | 22(16.5–32) | 31(23–45) | 42(25.5–65.5) |  < 0.001* |
The total dosages of AMB, median (IQR), mg | 705(530–995) | 740(543–1359) | 985(577–2080.25) | 0.088 |
The average daily dosages of 5-FC, mean ± SD, mg/kg/d | 91.41 ± 15.21 | 86.41 ± 24 | 80.16 ± 24.97 | 0.026* |
The lengths of 5-FC, median (IQR), days | 24(18.5–33) | 38(27–60) | 47.5(34.25–73.25) |  < 0.001* |
The total dosages of 5-FC, median (IQR), mg | 108,000(92,200–165,600) | 160,000(111,000–237,600) | 212,250(154,125–270,000) |  < 0.001* |
the average daily dosages of VOR or FLU, median (IQR), mg/d | 400(400–400) | 600(400–600) | NA | NA |
The length of VOR or FLU median (IQR), days | 24(20–33) | 33(23–44) | NA | NA |
The average daily dosages of mannitol (IQR), ml | 277.21(200–342.61) | 350(245.96–445.65) | 367.90(293.80–474.76) |  < 0.001* |
The length of mannitol, median (IQR), days | 8(3–17) | 28(9–44) | 46(27–72) |  < 0.001* |
The average daily dosages of potassium supplementation, median (IQR), g/d | 5.02(3.44–6.38) | 6.1(4.25–7.26) | 5.94(4.73–7.09) | 0.077 |
The average daily dosages of fluid supplementation, mean ± SD, ml/d | 1532.13 ± 459.11 | 1662.92 ± 477.35 | 1416.70 ± 529.24 | 0.059 |