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Table 2 Baseline characteristics of patients

From: Amphotericin B plus fluorocytosine combined with voriconazole for the treatment of non-HIV and non-transplant-associated cryptococcal meningitis: a retrospective study

Variables

Group I (n = 49)

Group II(n = 71)

Group III(n = 28)

P-value

Age, mean ± SD, years

48.20 ± 16.44

44.58 ± 14.48

46.00 ± 11.78

0.417

Gender, male (n, %)

32(65.3%)

47(66.2%)

23(82.1%)

0.243

Weight, mean ± SD, Kg

60.596 ± 11.1665

57.757 ± 10.9580

60.346 ± 11.2328

0.340

Length of first hospital stay days, median (IQR), days

25(20–34.5)

43(29–62)

50.5(43–77.5)

 < 0.001*

Admission time (n, %), years

 < 0.001*

 2011–2015

0(0%)

24(33.8%)

21(75.0%)

 2016–2020

49(100%)

47(66.2%)

7(25.0%)

Underlying diseases (n, %)

 autoimmune disorder

7(14.3%)

6(8.5%)

0(0%)

0.104

 immunosuppressive agent

8(16.3%)

7(9.9%)

1(3.6%)

0.213

 diabetes mellitus

6(12.2%)

5(7.0%)

0(0%)

0.135

 liver cirrhosis

0(0%)

2(2.8%)

1(3.6%)

0.428

 Altered mental state (n, %)

5(10.2%)

7(9.9%)

6(21.4%)

0.257

BMRC stage (n, %)

0.632

 1

0(0%)

2(2.8%)

0(0%)

 2

42(85.7%)

60(85.4%)

22(78.6%)

 3

7(14.3%)

9(12.7%)

6(21.4%)

CSF opening pressure, median (IQR), mmH2O

240(147.5–330)

266(175–330)

280(162.75–330)

0.311

CSF opening pressure >  = 200 (n, %)

31(63.3%)

51(71.8%)

18(64.3%)

0.565

CSF cryptococci, median (IQR), count/ml

56(0–5718)

1296(56–5376)

505(17.25–4308.75)

0.254

CSF white blood cell, median (IQR), *10^6/l

120(47.5–185)

120(64–190)

106.5(34.5–241.5)

0.671

CSF protein, median (IQR), g/l

0.817(0.565–1.362)

0.818(0.56–1.25)

0.655(0.4125–0.9825)

0.133

CSF glucose, median (IQR), mmol/l

1.86(0.73–2.775)

1.33(0.71–2.31)

1.935(1.0825–2.665)

0.366

CSF chloride, median (IQR), mmol/l

116.8(110.8–121.15)

116(109.4–119.3)

117.5(113.35–120.95)

0.158

  1. Group I: AMB + 5-FC + VOR, Group II: AMB + 5-FC + FLU, Group III: AMB + 5-FC. NA: Not available. Data were presented as the mean ± SD, median (IQR). Continuous variables were analyzed by one-way ANOVA or Kruskal–Wallis H test. Categorical variables were analyzed by Chi-square test or Fisher’s exact test
  2. *P < 0.05