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Table 4 Multivariate analysis of factors associated with CSF clearance failure at 2 weeks follow-up in non-HIV and non-transplant-associated CM patients

From: Amphotericin B plus fluorocytosine combined with voriconazole for the treatment of non-HIV and non-transplant-associated cryptococcal meningitis: a retrospective study

Variable

Univariatea

Multivariateb

 

OR (95% CI)

p-value

OR (95% CI)

p-value

Group (ref: Group I)

NA

NA

NA

NA

Group II

3.33 (1.53,7.23)

0.002*

3.35 (1.43,7.82)

0.005*

Group III

3.39 (1.22,9.43)

0.019*

3.80 (1.23,11.81)

0.021*

Autoimmune disorder

1.20 (0.35,4.11)

0.770

0 (0, Inf)

0.999

Immunosuppressive agent

1.66 (0.51,5.43)

0.403

17,144,397.01 (0, Inf)

0.999

Diabetes mellitus

0.61 (0.18,2.09)

0.429

0.44 (0.08,2.47)

0.353

Liver cirrhosis

3,123,919.74 (0, Inf)

0.986

10,359,331.41 (0, Inf)

0.999

Number of lumbar punctures within 2 weeks

1.22 (0.91,1.64)

0.180

1.32 (0.89,1.96)

0.168

Baseline CSF OP

1.00 (1.00,1.01)

0.009*

1.00 (1.00,1.01)

0.118

Baseline CSF cryptococci

1.00 (1.00,1.00)

0.038*

1.00 (1.00,1.00)

0.078

  1. Group I: AMB + 5-FC + VOR, Group II: AMB + 5-FC + FLU, Group III: AMB + 5-FC. NA: Not available
  2. aLogistic regression analysis. p-values obtained are 2-tailed
  3. bFinal logistic regression model containing the covariates with p < 0.2 from the univariable models and some important covariates (autoimmune disorder, immunosuppressive agent, diabetes mellitus, liver cirrhosis) associated with outcome as previous literature reported
  4. *p < 0.05