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Table 5 The characteristics of patients after 4 weeks follow-up

From: Amphotericin B plus fluorocytosine combined with voriconazole for the treatment of non-HIV and non-transplant-associated cryptococcal meningitis: a retrospective study

Variables

Group I (n = 41)

Group II(n = 67)

Group III(n = 26)

P-value

BMRC stage (n, %)

0.073

 1

17(41.5%)

12(17.9%)

5(19.2%)

 2

23(56.1%)

52(77.6%)

20(76.9%)

 3

1(2.4%)

3(4.5%)

1(3.8%)

Number of lumbar punctures within 4 weeks, median (IQR)

5(3.5–5.5)

5(4–6)

5(4–5)

0.808

CSF opening pressure, median (IQR), mmH2O

162.5(119–211.25)

210(145–260)

240(170–230)

0.006*

CSF cryptococci, median (IQR), count/ml

38.5(0–179.5)

1(0–357)

3(0–56)

0.518

CSF clearance

Case (n, %)

25(61.0%)

36(53.7%)

7(26.9%)

0.02*

CSF white blood cell, median (IQR), *10^6/l

43.5(18.5–78.25)

50(22–86)

64(16–90)

0.734

CSF protein, median (IQR), g/l

0.97(0.40–1.36)

0.80(0.47–2.27)

0.87(0.42–1.06)

0.446

CSF glucose, median (IQR), g/l

2.25(0.87–3.55)

2.12(1.06–2.64)

2.38(1.76–2.71)

0.456

CSF chloride, median (IQR), mmol/l

122.3(117.4–124.73)

120.8(117.1–123)

122.1(117.1–124.9)

0.395

  1. Group I: AMB + 5-FC + VOR, Group II: AMB + 5-FC + FLU, Group III: AMB + 5-FC. NA: Not available. Data were presented as the mean ± SD, median (IQR). Continuous variables were analyzed by one-way ANOVA or Kruskal–Wallis H test. Categorical variables were analyzed by Chi-square test or Fisher’s exact test
  2. *P < 0.05