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Fig. 4 | BMC Neurology

Fig. 4

From: Toxic leukoencephalopathy with axonal spheroids caused by chemotherapeutic drugs other than methotrexate

Fig. 4

Microscopic findings of Case 1. A Hematoxylin and eosin stain of the optic pathway of the left occipital lobe in case 1 revealed many axonal spheroids (arrows). B Neurofilaments (NF) stain revealed several oval-to-round axonal spheroids (yellow arrows) with the vacuolar change of the optic pathway of the left occipital lobe. C CD68 stain revealed many CD68-positive foamy macrophages in the optic pathway of the left occipital lobe. D TMEM119 stain was negative, suggesting complete loss of microglia in the optic pathway of the occipital lobe. The left inlet show TMEM-positive microglia in the neocortex of this patient (Bar A-D: 200 µm)

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BMC Neurology

ISSN: 1471-2377

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