| Case 1 | Case 2 |
---|---|---|
Age/Gender | 64/F | 63/M |
Active problem | Loss of consciousness, sleep tendency, type I respiratory failure due to aspiration pneumonia and sepsis | Disorientation, drowsy mentality, sleep tendency, coma Pneumonia, sepsis, & DIC, multiorgan failure |
Underlying disease | Relapsed Acute undifferentiated myelogenous leukemia | Myelodysplastic syndrome excess blast 1 (MDS-EB1) |
Chemotherapy-Regimen | FLAG, IDAC | Azacitidine #3 |
Transplant | MUD-alloPBSCT | MUD-alloPBSCT |
Autopsy finding | Numerous axonal spheroid with vacuolar changes of the white matter and exogenous foamy macrophage (CD68-positive/TMEM119-negative) infiltration Beta-amyloid deposit in the degenerated axons of the optic tract of occipital and temporal lobes | Numerous axonal spheroids with vacuolation of the white matter with exogenous foamy macrophage (CD68-positive/TMEM119-negative) infiltration Beta-amyloid deposit in the axons, extensively in the most white matter |
Main involving area | The white matter of the occipital and temporal lobe | The white matter of the occipital, temporal, and parietal lobe |
T- or B-lymphocytes | Absent in the entire brain parenchyma | Absent in the entire brain parenchyma |
Survival | 3Â months after alloPBSCT | 4Â months after alloPBSCT (about 3Â months after onset of disorientation) |