Characteristics | Patients, No. (%) | ||
---|---|---|---|
Subacute (n = 32) | Chronic (n = 47) | P-value | |
Age, mean, years | 34.2 | 39.4 | 0.13 |
Gender | |||
Male | 23/32 (71.9) | 30/47 (63.8) | 0.48 |
Female | 9/32 (28.1) | 17/47 (36.2) | |
Symptoms | |||
Headache | 29/32 (90.6) | 40/47 (85.1) | 0.73 |
Fever | 24/32 (75.0) | 20/46 (43.5) | 0.01 |
Nausea/Vomiting | 29/32 (90.6) | 30/47 (63.8) | 0.01 |
Neurological symptomsa | 7/32 (21.9) | 24/47 (51.1) | 0.01 |
Visual impairment | |||
Blurred vision | 10/32 (31.3) | 13 (27.7) | 0.29 |
Diplopia | 4/32 (12.5) | 14/47 (29.8) | |
Photophobia | 1/32 (3.1) | 2/47 (4.3) | |
Weight loss | 1/32 (3.1) | 5/47 (10.6) | 0.39 |
Night sweats | 1/31 (3.2) | 4/47 (8.5) | 0.64 |
Seizure | 5/30 (16.7) | 6/42 (14.3) | 1.00 |
Dyspnea | 1/32 (3.1) | 1/47 (2.1) | 1.00 |
Cough | 1/32 (3.1) | 4/47 (8.5) | 0.64 |
Tinnitus | 1/32 (3.1) | 0/47 | 0.40 |
Signs | |||
Altered mental status | 10/32 (31.3) | 11/46 (23.9) | |
Nuchal rigidity | 13/24 (54.2) | 11/29 (37.9) | 0.27 |
Papillary edema | 2/10 (20.0) | 7/14 (50.0) | 0.21 |
Laboratory analysis | |||
WBC count, mean, × 109/L | 10.8 | 9.0 | 0.18 |
CSF analysis | |||
WBC count, mean, cells/mm3 | 2244.3 | 482.1 | 0.04 |
Pleocytosis | |||
Neutrophilic | 7/29 (24.1) | 17/33 (51.5) | 0.00 |
Monocytic | 22/29 (75.9) | 12/33 (36.4) | |
Lymphocytic | 0/29 | 4/33 (12.1) | |
Elevated protein | 23/29 (79.3) | 26/38 (68.4) | 0.40 |
Decreased glucose | 25/27 (92.6) | 22/27 (81.5) | 0.42 |
Radiology | |||
Normal brain CT scan | 13/17 (76.5) | 11/18 (61.1) | 0.39 |
Normal brain MRI | 6/8 (75.0) | 9/17 (52.9) | 0.67 |
Management | |||
Steroid therapy | 14/32 (43.8) | 17/35 (48.6) | 0.80 |
Anti-TB therapy | 13/32 (40.6) | 13/45 (28.9) | 0.33 |
Empirical acyclovir therapy | 11/31 (35.5) | 12/33 (36.4) | 1.00 |
Empirical antibiotic therapy | 28/30 (93.3) | 27/30 (90.0) | 1.00 |
Death | 7/31 (22.6) | 5/44 (11.4) | 0.22 |