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Table 2 Hazard ratio (95% CI) of mortality in patients with glioma

From: Exploring the relationship between age and prognosis in glioma: rethinking current age stratification

  

Model 1

Model 2

Model 3

Age

Mortality

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

Four groups of age

 Birth to 19 years

46.7%

1 (reference)

 

1 (reference)

 

1 (reference)

 

 20-39 years

48.3%

1.02 (0.95 to 1.1)

0.557

1.03 (0.96 to 1.11)

0.384

1.03 (0.96 to 1.11)

0.399

 40-64 years

81.2%

3.07 (2.88 to 3.27)

<0.001

2.24 (2.09 to 2.40)

<0.001

2.23 (2.09 to 2.39)

<0.001

 65-84 years

92.8%

6.89 (6.45 to 7.35)

<0.001

4.56 (4.26 to 4.88)

<0.001

4.56 (4.26 to 4.88)

<0.001

Per 10 years of age

 0-9 years

47.0%

1.06 (0.93 to 1.20)

0.398

1.00 (0.88 to 1.13)

0.941

1.00 (0.88 to 1.13)

0.966

 10-19 years

46.2%

1 (reference)

 

1 (reference)

 

1 (reference)

 

 20-29 years

43.7%

0.90 (0.82 to 1.00)

0.050

0.91 (0.82 to 1.00)

0.058

0.91 (0.82 to 1.00)

0.060

 30-39 years

51.0%

1.14 (1.04 to 1.25)

0.005

1.12 (1.02 to 1.23)

0.018

1.12 (1.02 to 1.23)

0.018

 40-49 years

70.9%

2.09 (1.91 to 2.28)

<0.001

1.71 (1.56 to 1.87)

<0.001

1.70 (1.56 to 1.86)

<0.001

 50-59 years

83.4%

3.48 (3.19 to 3.79)

<0.001

2.41 (2.21 to 2.63)

<0.001

2.41 (2.21 to 2.63)

<0.001

 60-69 years

88.4%

4.91 (4.51 to 5.35)

<0.001

3.27 (3.00 to 3.57)

<0.001

3.27 (3.00 to 3.57)

<0.001

 70-79 years

93.4%

7.95 (7.29 to 8.66)

<0.001

5.18 (4.75 to 5.66)

<0.001

5.19 (4.76 to 5.67)

<0.001

 80-84 years

97.0%

12.85 (11.74 to 14.06)

<0.001

8.44 (7.70 to 9.25)

<0.001

8.48 (7.74 to 9.29)

<0.001

  1. HR Hazard ratio, CI Confidence interval. Model 1: Unadjusted covariates; Model 2: Adjusted for year (2000-2006,2007-2012 or 2013-2018), histology (diffuse astrocytoma, anaplastic astrocytoma, glioblastoma or oligodendroglioma) and location (infratentorial, supratentorial or overlapping lesion) based on optimal full subset regression. Model 3: Adjusted for year (2000-2006,2007-2012 or 2013-2018), histology (diffuse astrocytoma, anaplastic astrocytoma, glioblastoma or oligodendroglioma), location (infratentorial, supratentorial or overlapping lesion), race (black, white or other) and gender (female or male)