Fig. 4From: Case report of two affected siblings in a family with thiamine metabolism dysfunction syndrome 5: a rare, but treatable neurodegenerative diseaseSchematic illustration of the changes in hydrogen bonds. The different amino acids are shown in different colors. The hydrogen bonds are shown as red spheres. The protein modeling showed that mutation Ile75Asn resulting in alteration of hydrogen bonds, that forming a new hydrogen bonds with R81Back to article page