Table 3 Criteria ASIA syndrome as proposed by Shoenfeld et al. [1, 3]

A—Major criteria

 (a) exposure to an external stimulus prior to clinical manifestation (e.g. infection, vaccine, silicone, ...)

 (b) typical clinical manifestations

  I. myalgia, myositis or muscle weakness

  II. arthralgia and/or arthritis

  III. chronic fatigue, sleep disturbances

  IV. neurological manifestations

  V. cognitive impairment

  VI. pyrexia, dry mouth

 (c) removal of trigger induces improvement

B— Minor criteria

 (a) autoantibodies or antibodies directed against the adjuvant

 (b) specific HLA (e.g. HLA DRB1, HLA DQB1)

 (c) evolvement of an autoimmune disease (e.g. SSc)