Skip to main content
Fig. 2 | BMC Neurology

Fig. 2

From: Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer’s disease polygenic risk score

Fig. 2

Associations between APOE genotype, AD-PRS and amyloid-β status. Values given are odds ratio [95% confidence interval] as estimated by Generalized estimating equations (predictor: APOE genotype or normalized AD-PRS; outcome: amyloid-β status (reference = amyloid-β negative status), including random effect for family-relatedness (comparable with logistic regressions, but corrected for clustering in the data), adjusted for age, sex, center, and population substructure (PC1-3). The odds ratio for the AD-PRS reflects the odds of having an amyloid-β positive status per one standard deviation increase in the AD-PRS. Amyloid-β status was based on visual read [18F]flutemetamol PET standardized uptake value images. Abbreviations: AD = Alzheimer’s Disease; APOE = apolipoprotein E; CI = confidence interval; OR = odds ratio; PC = principal components; PRS = polygenic risk score

Back to article page

BMC Neurology

ISSN: 1471-2377

Contact us