Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
Odds ratio for seizure activity (95% CI) | P value | Odds ratio for seizure activity adjusting for admission GCS (95% CI) | p value | |
Clinical variables | ||||
Age | 0.99 (0.97–1.01) | 0.390 | – | – |
Sex (male) | 1.28 (0.49–3.35) | 0.618 | – | – |
GCS | 0.67 (0.53–0.84) | < 0.001** | 0.61 (0.46–0.83) | 0.001** |
Duration of symptoms in days | 1.01 (0.99–1.02) | 0.424 | – | – |
Aetiology | ||||
Unknown | 1.56 (0.58–4.17) | 0.381 | – | – |
Herpes simplex virus | 2.34 (0.57–9.58) | 0.236 | – | – |
Other infective cause | 0.79 (0.22–2.89) | 0.726 | – | – |
Auto-immune mediated | 0.37 (0.12–1.14) | 0.083 | – | – |
Regional analysis | ||||
Visible oedema on MRI | 4.74 (1.65–13.58) | 0.004** | 0.63 (0.05–8.31) | 0.723 |
Presence of cortical oedema | 4.91 (1.79–14.39) | 0.003** | 5.48 (1.62–18.51) | 0.006* |
Presence of frontal lobe oedema | 2.60 (0.90–8.29) | 0.088 | – | – |
Presence of temporal lobe oedema | 3.15 (1.14–9.50) | 0.033* | 0.67 (0.09–4.46) | 0.674 |
Presence of parietal lobe oedema | 1.56 (0.54–4.75) | 0.419 | – | – |
Presence of occipital lobe oedema | 3.06 (0.84–14.61) | 0.113 | – | – |
Presence of subcortical oedema | 2.39 (0.78–8.30) | 0.142 | – | – |
Presence of cerebellum oedema | 1.69 (0.49–6.83) | 0.427 | – | – |
Number of structures with oedema | 1.36 (1.09–1.76) | 0.012* | 1.10 (0.72–1.68) | 0.646 |
Volumetric analysis | ||||
Total volume of oedema | 1.75 (1.13–2.81) | 0.015* | 0.72 (0.16–3.19) | 0.665 |
Cortical volume of oedema | 1.79 (1.15–2.89) | 0.013* | 1.90 (1.12–3.21) | 0.017* |
Volume of frontal lobe oedema | 1.36 (0.76–2.43) | 0.300 | – | – |
Volume of temporal lobe oedema | 1.77 (1.06–2.95) | 0.029* | 1.02 (0.38–2.72) | 0.966 |
Volume of parietal lobe oedema | 1.27 (0.68–2.37) | 0.459 | – | – |
Volume of occipital lobe oedema | 3.08 (0.84–11.31) | 0.089 | – | – |
Volume of subcortical oedema | 1.49 (0.72–3.12) | 0.286 | – | – |
Volume of cerebellum oedema | 1.28 (0.52–3.12) | 0.589 | – | – |