Table 1 International Classification of Sleep Disorders, Third Edition, Diagnostic Criteria
Narcolepsy Type 1 Criteria A and B | Narcolepsy Type 2 All Criteria A-E | Central Hypersomnia due to medical disorder All Criteria A-F |
|---|---|---|
A. Daily periods of irrepressible need to sleep or daytime lapses into sleep, present for at least 3 mo | A. Daily periods of irrepressible need to sleep or daytime lapses into sleep, present for at least 3 mo | A. Daily periods of irrepressible need to sleep or daytime lapses into sleep, present for at least 3 mo |
B. Either 1 or 2 or both | B. Mean sleep latency ≤ 8 min and two or more SOREMPs on MSLT. REM within 15 min of sleep onset on the preceding nocturnal polysomnogram may replace one of the SOREMPs. | B. Daytime occurs as consequence of a medical condition. |
1. Cataplexy and mean sleep latency ≤ 8 min and two or more SOREMPs on MSLT. REM within 15 min of sleep onset on the preceding nocturnal polysomnogram may replace one of the SOREMPs. | C. No cataplexy | C. The mean latency is ≤ 8 min), and fewer than two SOREMPs on MSLT. |
2. Low CSF hypocretin-1 concentration (< 110 pg/mL or less than one-third of control values) | D. CSF hypocretin-1 concentration has not been measured or CSF hypocretin-1 concentration is ≥ 110 pg/mL or greater than one-third of control values. | D. Either 1 or 2 or both:. 1.Mean sleep latency ≤ 8 min on MSLT. 2. Total 24-h sleep time ≥ 660 min on 24-h polysomnographic monitoring or wrist actigraphy (averaged over ≥ 7 d) |
E. The hypersomnolence and/or MSLT findings are not better explained by other causes. | E. Insufficient sleep syndrome is ruled out. | |
F. The hypersomnolence and/or MSLT findings are not better explained by other sleep disorder or medications. |