Fig. 2

Neuroradiological findings. a Transverse fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) shows bilateral frontal lobe atrophy. b Brain perfusion single-photon emission computed tomography (SPECT) easy Z-score Imaging System (eZIS) analysis (FUJIFILM Toyama Chemical Co., Ltd., Tokyo, Japan) shows relative hypoperfusion in the frontal lobe. The color scale for the Z score is shown in the right part of the figure. The colored areas represent Z scores > 2. c Transverse FLAIR MRI performed 10 years later shows remarkable bilateral frontal and temporal lobe atrophy. d eZIS analysis performed 10 years later reveals remarkable hypoperfusion in the frontal and parietal lobes