Table 3 Brain regions (local maxima) showing significant atrophy between patients in Gradient 1 and 2 vs. S-FTD
Contrast | Region | Cluster k | x | y | z | Peak t | Peak z |
|---|---|---|---|---|---|---|---|
MAPT case < S-FTD (GR3) | B Precuneus | 97 | 6 | - + 45 | 51 | 6.69 | 3.09 |
B Anterior cingulated cortex | 82 | 5 | - + 14 | 42 | 6.56 | 3.70 | |
B Parahippocampal gyrus | 95 | 27 | - + 21 | 12 | 10.78 | 4.11 | |
L Middle frontal gyrus/BA46 | 94 | -34 | 32 | 27 | 7.01 | 3.36 | |
B Angular gyrus /BA46 | 64 | 42 | -60 | 40 | 10.30 | 4.09 | |
R Posterior cingulated cortex | 56 | 6 | -47 | 8 | 9.16 | 4.01 | |
B Insula | 56 | 26 |  + -23 | -8 | 7.99 | 3.09 | |
R Caudate | 109 | -14 | 12 | 6 | 8.56 | 3.70 | |
TARDBP case < S-FTD (GR3) | R Posterior cingulated cortex | 79 | 6 | -45 | 8 | 7.99 | 3.09 |
B Anterior cingulated cortex | 80 | 5 |  + -12 | 40 | 7.56 | 3.70 | |
R Precuneus | 95 | 6 |  + -47 | 48 | 8.81 | 3.57 | |
B Parahippocampal gyrus | 54 | 27 |  + -21 | 12 | 7.01 | 3.36 | |
L Middle frontal gyrus/BA8 | 64 | -30 | 36 | 48 | 8.30 | 3.79 | |
B Superior Parietal cortex | 56 | 15 | -52 | 66 | 6.16 | 3.65 | |
R cerebellum | 124 | 24 | 45 | -12 | 6.65 | 3.09 | |
TREM2 case < S-FTD (GR3) | B Orbitofrontal cortex | 79 | 24 |  + -45 | -12 | 7.89 | 3.09 |
B Anterior cingulated cortex | 80 | 5 |  + -12 | 40 | 7.06 | 3.70 | |
R Dorsal lateral Prefrontal cortex | 95 | 36 | -12 | 35 | 7.11 | 3.57 | |
R Insula | 54 | 27 | -21 | -12 | 6.12 | 3.36 | |
B Superior temporal cortex | 64 | 58 | -37 | 9 | 5.93 | 3.79 | |
B Cerebellum | 56 | 24 | - + 45 | -12 | 9.16 | 3.65 | |
H1H2 cases < S-FTD (GR3) | R Orbitofrontal cortex | 79 | 24 |  + -45 | -12 | 10.09 | 4.09 |
R Insula | 80 | 27 | -21 | 40 | 7.06 | 3.70 | |
R Medial temporal gyrus | 112 | 40 | -1 | 48 | 7.11 | 3.57 | |
H2H2 cases < S-FTD (GR3) | R Dorsolateral prefrontal cortex | 59 | -36 | 12 | 37 | 6.03 | 3.09 |
R Anterior cingulated cortex | 82 | 5 |  + -12 | 37 | 5.66 | 3.70 | |
R Superior parietal lobe | 95 | 15 | -52 | 66 | 6.78 | 3.57 | |
L Medial temporal gyrus | 94 | 40 | 2 | -16 | 7.01 | 3.36 | |
APOE E2E3 cases < S-FTD (GR3) | R Medial temporal gyrus | 70 | 40 | -1 | -48 | 7.59 | 3.09 |
R Inferior temporal gyrus | 82 | -36 | 12 | 37 | 8.56 | 3.70 | |
APOE E3E4 cases < S-FTD (GR3) | B Angular gyrus | 109 | 24 | 45 | -12 | 10.02 | 4.09 |
R Dorsolateral prefrontal cortex | 88 | -36 | 12 | 37 | 7.86 | 3.70 | |
APOE E4E4 cases < S-FTD (GR3) | R Medial temporal gyrus | 66 | 40 | -1 | -48 | 11.01 | 4.09 |
L Inferior parietal lobe | 82 | -46 | -36 | 42 | 9.06 | 3.70 | |
S-FTD (GR3) < GR1and GR2 | |||||||
S-FTD (GR3) < MAPT case | B Medial Cingulated cortex | 62 | 5 |  + -12 | 37 | 5.06 | 3.09 |
R Caudate | 65 | -14 | 12 | 6 | 5.11 | 3.27 | |
R Putamen | 65 | -17 | 12 | 9 | 5.26 | 3.45 | |
S-FTD (GR3) < TARBP case | R Superior parietal lobe | 56 | 15 | -52 | 66 | 5.22 | 3.44 |
B Inferior temporal lobe | 52 | -36 | 12 | 37 | 5.33 | 3.49 | |
L Anterior Cingulated cortex | 58 | 5 |  + -12 | 37 | 5.02 | 3.09 | |
S-FTD (GR3) < APOE ε4 | R Superior parietal lobe | 56 | 15 | -52 | 66 | 5.12 | 3.37 |
B Anterior cingulate cortex | 52 | -36 | 12 | 37 | 5.42 | 3.43 | |