PerBrain: a multimodal approach to personalized tracking of evolving state-of-consciousness in brain-injured patients: protocol of an international, multicentric, observational study

Table 1 Overview of patient (T1, T2, T3) and caregiver (C0, C1, C2, C3) assessments

C0 Before patients’ assessment	T1 1-2 m from injury	C1 1-2w after results communi-cation	T2 4-7 m from injury	C2 1-2w after results communi-cation	T3 9-12 m from injury	C3 1-2w after results communi-cation
Personal data FCV-19S Religious/ spiritual information BIPQ EQ-5D-5L AcQoL HADS RS14 SOC-13 Treatment choices survey	Patient’s multimodal assessment ^a + Doctor’s communication of results to caregivers	FCV-19S BIPQ EQ-5D-5L HADS + qualitative interview (N = 9)	Patient’s multimodal assessment ^a + Doctor’s communication of results to caregivers	FCV-19S BIPQ EQ-5D-5L AcQoL HADS Treatment choices survey	Patient’s assessment at home (CRS-R & GOS-E)	FCV-19S Religious/ spiritual information BIPQ EQ-5D-5L AcQoL HADS RS14 SOC-13

m months, w weeks, FCV-19S Fear of COVID-19 Scale; BIPQ Brief Illness Perception Questionnaire, EQ-5D-5L European Quality of Life-5 Dimensions, AcQoL Adult Carer Quality of Life Questionnaire, HADS Hospital Anxiety and Depression Scale, RS14 14-Item Resilience Scale, SOC-13 13-item Sense of Coherence Scale
^a Patient’s multimodal assessments at T1 and T2 include behavioral scales (CRS-R, GOS-E), qEEG, TMS-EEG, structural and functional MRI, and nasal respiration measurements (24h and odor dependent).

ISSN: 1471-2377