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Table 1 Clinical features of MOG-IgG-positive ADEM patients compared to MOG-IgG-negative ADEM patients

From: Clinical characteristics and associated factors of pediatric acute disseminated encephalomyelitis patients with MOG antibodies: a retrospective study in Hangzhou, China

Clinical features

MOG-IgG-positive

n = 35

MOG-IgG-negative

n = 50

Univariate analyses

p value

Basic Information

 Gender, male, n (%)

21 (60)

28 (56)

0.713

 Onset age, months, median (range)

69 (20–138)

76 (13–178)

0.317

 Disease duration, days, median (range)

10 (1–30)*

6 (0.5–30)

0.048

 Hospital stay, days, median (range)

17 (6–35)

16 (7–40)

0.567

 With respiratory symptoms, n (%)

10 (28.6)

17 (34)

0.771

 Onset at winter or spring, n (%)

23 (65.7)

24 (48)

0.358

Clinical characteristics

 Encephalopathy, n (%)

  Altered consciousness, n (%)

21 (60)

38 (76)

0.152

  Behavioral changes, n (%)

14 (40)

12 (24)

0.152

 Fever, n (%)

23 (65.7)

37 (74)

0.472

 Headache, n (%)

15 (42.9)

26 (52)

0.509

 Vomiting, n (%)

13 (37.1)

22 (44)

0.655

 Seizures, n (%)

8 (22.3)

13 (26)

0.801

 Optic neuritis, n (%)

6 (17.1)

4 (8)

0.305

 Meningeal involvement, n (%)

11 (31.4)*

4 (8)

0.008

 Ataxia, n (%)

3 (8.6)

6 (12)

0.731

 Limb weakness, n (%)

13 (37.1)

17 (34)

0.820

CSF analysis

 Pleocytosis, n (%)

29 (82.9)

32 (64)

0.858

 Protein elevation, n (%)

13 (37.1)

15 (30)

0.550

 Positive OB, n (%)

5 (14.3)

3 (6)

0.265

Therapeutic characteristics

 Neurological sequel, n(%)

5 (14.3)

11 (22)

0.413

 Relapse, n (%)

5 (14.3)*

1 (2)

0.030

 IVIG therapy, n (%)

21 (60)

35 (70)

0.339

 Methylprednisolone therapy

35 (100)

50 (100)

1.000

  1. ADEM acute disseminated encephalomyelitis, MOG myelin oligodendrocyte glycoprotein, MOG-IgG-positive ADEM patients with positive anti-MOG antibodies in serum, MOG-IgG-negative ADEM patients without positive anti-MOG antibodies in serum, IVIG intravenous immunoglobulin; univariate analyses were confirmed by the t-test, chi-square or Mann-Whitney U-test.
  2. *indicates MOG-IgG-positive group vs. MOG-IgG-negative group, p < 0.05.