Table 1 Inclusion and exclusion criteria of BERLimmun (Exclusion criteria are only considered at baseline while drop-out criteria are checked at each follow-up visit)

Inclusion criteria

- MS according to McDonald 2017 criteria [24],

NMOSD according to IPND NMO Diagnostic 2015 criteria [25]

OR other diagnosis of autoimmune disease with CNS involvement, including

clinically or radiologically isolated syndromes, CRION or MOGAD

OR

self-declared healthy control participant

- ≥ 18 years of age

- active health insurance

- competent to give written informed consent

- signed consent

Exclusion criteria

- contraindication to MRI investigation

- pregnancy

- relevant other disease that conflicts with study accomplishment according to investigator

- inability to cooperate

Drop-out criteria

- withdrawal of consent

- non-compliance with protocol (decision by study board)

- condition hindering study continuation (decision by study board)