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Table 3 Plasma and CSF concentrations of NfL between groups

From: Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus

 

n

P-log-NfL, pg/ml, mean (SD)

n

CSF-log-NfL, pg/ml, mean (SD)

SLE patients

72

0.84 (0.17)

32

2.58 (0.30)

Healthy controls

26

0.71 (0.17)

0

N/A

p value

 

0.003

 

N/A

NPSLE (SLICC A model)

16

0.87 (0.13)

8

2.73 (0.34)

Non-NPSLE (SLICC A model)

56

0.83 (0.18)

24

2.53 (0.27)

p value

 

0.40

 

0.11

NPSLE (SLICC B model)

23

0.87 (0.14)

12

2.65 (0.30)

Non-NPSLE (SLICC B model)

49

0.83 (0.18)

20

2.54 (0.30)

p value

 

0.33

 

0.30

NPSLE (ACR model)

44

0.86 (0.16)

21

2.62 (0.32)

Non-NPSLE (ACR model)

28

0.81 (0.17)

11

2.51 (0.28)

p value

 

0.17

 

0.32

  1. n Number of subjects, P Plasma, Log Log-transformed value, NfL Neurofilament Light, SD Standard deviation, CSF Cerebrospinal fluid, N/A not applicable, SLICC Systemic Lupus International Collaborating Clinics, ACR American College of Rheumatology