Table 1 Clinical and MRI characteristics of Diffuse midline glioma, H3 K27-altered and glioma in the midline without H3 K27-altered
All patients (n = 35) | Histone-H3K27 Mutant (n = 14) | Histone-H3K27 Wild-type (n = 21) | P Value | ||
|---|---|---|---|---|---|
Median age (years) | 29 | 19 | 33 | < 0.05 | |
Gender | Male | 24 | 11 | 13 | 0.461 |
Female | 11 | 3 | 8 | ||
The main part of tumor | Thalamus | 5 | 4 | 1 | < 0.01 |
Pons | 11 | 6 | 5 | ||
Vermis of cerebellum | 7 | 0 | 7 | ||
Medulla oblongata | 2 | 2 | 0 | ||
Cervical spinal cord | 4 | 0 | 4 | ||
Thoracic spinal cord | 1 | 0 | 1 | ||
Conus medullaris | 5 | 2 | 3 | ||
If involved the extramidline tissues | Limited to the midline | 17 | 7 | 10 | 0.890 |
Involved the extramidline tissues | 18 | 7 | 11 | ||
Mean survival time (years) | 1.8 | 1.4 | 2.0 | < 0.05 | |
Cystic degeneration and necrosis | Yes | 26 | 9 | 17 | 0.269 |
None | 9 | 5 | 4 | ||
Intratumoral hemorrhage | 8 | 4 | 4 | 0.511 | |
Enhancement degree | Mild enhancement | 8 | 5 | 3 | < 0.05 |
Moderate enhancement | 13 | 6 | 7 | ||
Obvious enhancement | 12 | 2 | 10 | ||
No enhancement | 2 | 1 | 1 | ||
Shape | Irregular | 15 | 7 | 8 | 0.486 |
Regular | 20 | 7 | 13 | ||
Edema | Mild edema | 12 | 5 | 7 | < 0.01 |
Moderate edema | 4 | 0 | 4 | ||
Severe edema | 4 | 0 | 4 | ||
No edema | 15 | 9 | 6 | ||
Basilar artery wrapping sign | For tumors located in the pon (n = 11) | 6/11 | 6/6 | 0/5 | < 0.01 |