Table 3 Univariate regression and multivariate survival model of prognostic covariates in patients with glioma

WHO grade

634

 G2

223

Reference

 G3

243

2.999 (2.007-4.480)

<0.001

1.736 (1.068-2.823)

0.026

 G4

168

18.615 (12.460-27.812)

<0.001

5.310 (1.604-17.572)

0.006

Gender

695

 Female

297

Reference

 Male

398

1.262 (0.988-1.610)

0.062

1.710 (1.090-2.684)

0.020

Age

695

 <=60

552

Reference

 >60

143

4.668 (3.598-6.056)

<0.001

4.056 (2.434-6.759)

<0.001

Race

682

 Asian

13

Reference

 Black or African American

33

1.578 (0.453-5.494)

0.474

 White

636

1.176 (0.376-3.677)

0.780

IDH status

685

 WT

246

Reference

 Mut

439

0.117 (0.090-0.152)

<0.001

0.470 (0.267-0.827)

0.009

1p/19q codeletion

688

 codel

170

Reference

 noncodel

518

4.428 (2.885-6.799)

<0.001

1.064 (0.552-2.050)

0.853

Primary therapy outcome

461

 PD

112

Reference

 SD

147

0.440 (0.294-0.658)

<0.001

0.340 (0.203-0.568)

<0.001

 PR

64

0.170 (0.074-0.391)

<0.001

0.182 (0.064-0.513)

0.001

 CR

138

0.133 (0.064-0.278)

<0.001

0.154 (0.071-0.335)

<0.001

Histological type

695

 Astrocytoma

195

Reference

Glioblastoma

168

6.791 (4.932-9.352)

<0.001

 Oligoastrocytoma

134

0.657 (0.419-1.031)

0.068

1.218 (0.707-2.098)

0.476

 Oligodendroglioma

198

0.580 (0.395-0.853)

0.006

0.645 (0.371-1.120)

0.119

TPM4

695

 Low

347

Reference

 High

348

4.972 (3.738-6.613)

<0.001

1.234 (0.780-1.953)

0.370