Fig. 1

Assessment of spatiall agreement in two representative patients. a - c One 77-year-old male sufferred from the occlusion of right middle cerebral artery. The time interval from symptom onset to CTP scan was 324 minutes, and the time interval from CTP to recanalization was50 minutes. The volume of ischemic core on baseline CTP and infarct area on follow-up DWI was 81.1 mL and 118.7 mL, respectively. After the ischemic core was identified on CTP- derived CBF maps a and infart area was manually outlined on post-treatment DWI b, infarct area on post-treatment DWI was registered to CTP c. The Dice similarity coefficient was 0.70, and the average Hausdorff distance was 0.35 mm. d - f One 47-year-old male sufferred from the occlusion of left internal carotid artery. The time interval from symptom onset to CTP scan was 199 minutes, and the time interval from CTP to recanalization was 85 minutes. The volume of ischemic core on baseline CTP was 2.60 mL, and the volume of infarct area on follow-up DWI was 2.23 mL. After the ischemic core was identified on CTP- derived CBF maps d and infart area was manually outlined on post-treatment DWI e, infarct area on post-treatment DWI was registered to CTP f. The Dice similarity coefficient was less than 0.01, and the average Hausdorff distance was 16.85 mm