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Fig. 5 | BMC Neurology

Fig. 5

From: A rare case of H3K27-altered diffuse midline glioma with multiple osseous and spinal metastases at the time of diagnosis

Fig. 5

Histological and immunohistochemical analysis. A H&E of the cranial stereotactic biopsy shows a tumor with small, round cells. B H&E of the lumbar biopsy reveals a partial rhythmic tumor with vascular proliferates (arrows). C H3K27M immunohistochemistry shows a strong nuclear positivity of the tumor cells. Endothelial cells of vascular proliferates are negative (arrows). D The tumor cells show a loss of the trimethylated lysine (H3K27-m3). E The tumor cells are ATRX-positive. F H3K27M immunohistochemistry reveals tumor cells in the retrieved bone sample

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BMC Neurology

ISSN: 1471-2377

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