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Fig. 3 | BMC Neurology

Fig. 3

From: Immunopathogenesis of viral infections in neurological autoimmune disease

Fig. 3

The mechanism SARS-Cov-2 induces neurological autoimmune system. SARS-Cov-2 enters the nervous system through different receptors. The viruses induce autoimmune reactions through several pathways. 1) The B- cells produce autoreactive antibodies against SARS-Cov-2, which damaged the normal tissues. 2) The recognized virus through PRR induces cytokine storm, resulting in damage to the healthy tissue and new antigens that, releases activate autoreactive T-cells. 3) Subsequently, the T-cell reaction destroys tissues and produce new self-antigens, which induce more autoreactive T-cells reaction. 4) The memory B-cells produce long-term autoantibodies in the absence of virus, which was associated with sustained CNS damage—created with BioRender.com

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