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Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Content type: Research article

    Intravenous thrombolysis has been recently introduced in Nepal for the management of acute ischemic stroke. Pre-hospital delay is one of the main reasons that hinder thrombolytic therapy. The objective of this...

    Authors: Gaurav Nepal, Jayant Kumar Yadav, Babin Basnet, Tirtha Man Shrestha, Ghanshyam Kharel and Rajeev Ojha

    Citation: BMC Neurology 2019 19:155

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  2. Content type: Case report

    Simultaneous cerebral and myocardial infarction is called cardiocerebral infarction (CCI), and is rarely encountered. Because of the narrow time window and complex pathophysiology, CCI is challenging to immedi...

    Authors: Soichiro Abe, Kanta Tanaka, Hiroshi Yamagami, Kazutaka Sonoda, Hiroya Hayashi, Shuichi Yoneda, Kazunori Toyoda and Masatoshi Koga

    Citation: BMC Neurology 2019 19:152

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  3. Content type: Research article

    This study aimed to investigate the cerebral blood flow (CBF) and frontal lobe cognitive function in severe internal carotid artery (ICA) stenosis patients with different types of collateral circulation.

    Authors: Wei Wei, Xingyang Yi, Jianghai Ruan, Xiaodong Duan, Hua Luo and Zhiyu Lv

    Citation: BMC Neurology 2019 19:151

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  4. Content type: Research article

    Mechanical thrombectomy has been proven as a standard care for moderate to severe ischemic stroke with anterior large vessel occlusion (LVO); however, whether it is equally effective in mild ischemic stroke (M...

    Authors: Xian-Jin Shang, Zhong-Hua Shi, Cai-Feng He, Shuai Zhang, Yong-Jie Bai, Yong-Tao Guo, Bo Sun, Shun Li, Huai-Ming Wang, Zhi-Ming Zhou, Wen-Jie Zi and Xin-Feng Liu

    Citation: BMC Neurology 2019 19:150

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  5. Content type: Research article

    Almost 40% of stroke patients have a poor outcome at 3 months after the index event. Predictors for stroke outcome in the early acute phase may help to tailor stroke treatment. Infection and inflammation are c...

    Authors: A. Mengel, L. Ulm, B. Hotter, H. Harms, S. K. Piper, U. Grittner, J. Montaner, C. Meisel, A. Meisel and S. Hoffmann

    Citation: BMC Neurology 2019 19:148

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  6. Content type: Research article

    Triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio is a marker of small/dense low-density lipoprotein particles, which are closely associated with various metabolic and vascular diseases. Howe...

    Authors: Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park, Hyuktae Kwon and Su-Min Jeong

    Citation: BMC Neurology 2019 19:147

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  7. Content type: Case report

    Heat stroke (HS) is a critical illness that can cause multiple organ dysfunction, including damage to the central nervous system (CNS), which can be life-threatening in severe cases. Brain lesions in patients ...

    Authors: Lizhi Cao, Juan Wang, Yaxuan Gao, Yumei Liang, Jinhua Yan, Yunhai Zhang, Mingqin Zhu, Tianfei Luo and Jiafeng Chen

    Citation: BMC Neurology 2019 19:133

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  8. Content type: Research article

    Mood disorder after stroke is common but drug and psychosocial treatments have been assessed with disappointing results. Preventing mood disorder from developing in the first place could be a better approach a...

    Authors: Kate Hill, Allan House, Peter Knapp, Carrie Wardhaugh, John Bamford and Andy Vail

    Citation: BMC Neurology 2019 19:128

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  9. Content type: Research article

    Immune cells are involved in all stages of acute ischaemic stroke (AIS) and possess both neuroprotective and neurodamaging properties. It has been suggested that immune system activation after stroke may be as...

    Authors: Neringa Jucevičiūtė, Paulius Mikužis and Renata Balnytė

    Citation: BMC Neurology 2019 19:127

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  10. Content type: Case report

    Fabry disease is rare, and the diagnosis is often delayed. Here, we describe a case of Fabry disease resulting in vasculopathy of the central nervous system. Magnetic resonance (MR) black-blood sequence (three...

    Authors: De-Zheng Kong, Ya-Hui Lian, Lin-Jing Wang, Chun-Mei Wang, Yang-Yang Meng and Hong-Wei Zhou

    Citation: BMC Neurology 2019 19:115

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  11. Content type: Case report

    Internal jugular vein stenosis (IJVS), characterized by a series of clinical manifestations, such as head and neck symptoms, visual and ear symptoms, as well as sleep disorder, has been receiving attention in ...

    Authors: Min Li, Yuan Sun, Chong Ching Chan, Chunqiu Fan, Xunming Ji and Ran Meng

    Citation: BMC Neurology 2019 19:112

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  12. Content type: Research article

    endovascular therapy (ET) is the standard of care for anterior circulation acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). The role of adjunctive intravenous thrombolysis (IVT) in these pat...

    Authors: Massimo Gamba, Nicola Gilberti, Enrico Premi, Angelo Costa, Michele Frigerio, Dikran Mardighian, Veronica Vergani, Raffaella Spezi, Ilenia Delrio, Andrea Morotti, Loris Poli, Valeria De Giuli, Filomena Caria, Alessandro Pezzini, Roberto Gasparotti, Alessandro Padovani…

    Citation: BMC Neurology 2019 19:103

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  13. Content type: Research article

    Exercise has failed to reduce falls in those with chronic stroke. A limitation of traditional exercise is that the motor responses needed to prevent a fall are not elicited (i.e. they lack processing specificity)...

    Authors: Jamie Pigman, Darcy S. Reisman, Ryan T. Pohlig, Tamara R. Wright and Jeremy R. Crenshaw

    Citation: BMC Neurology 2019 19:102

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  14. Content type: Research article

    A revised classification of cerebellar infarctions (CI) may uncover unrecognized associations with etiologic stroke subtypes. We hypothesized that obliquely oriented small cortical cerebellar infarction (SCCI)...

    Authors: Adrien Ter Schiphorst, Lavinia Tatu, Vincent Thijs, Christophe Demattei, Eric Thouvenot and Dimitri Renard

    Citation: BMC Neurology 2019 19:100

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  15. Content type: Case report

    Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare clinical entity, characterized by headaches, seizures, rapidly progressive cognitive decline, behavioral changes and magnetic resonance imagi...

    Authors: Yanjiao Du, Chao Liu, Congmin Ma, Xiaohui Xu, Xufeng Zhou, Haitao Zhou and Chao Huang

    Citation: BMC Neurology 2019 19:97

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  16. Content type: Study protocol

    Post-stroke lower limb spasticity (PSLLS) has a prevalence of 28–37%. PSLLS can cause difficulty in walking and reduce quality of life (QOL). Post stroke spasticity impairs the ability to intervene to improve ...

    Authors: Anupam Datta Gupta, Renuka Visvanathan, Ian Cameron, Simon A. Koblar, Stuart Howell and David Wilson

    Citation: BMC Neurology 2019 19:96

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  17. Content type: Case report

    Mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) is a mitochondrial cytopathy caused by mutations in mitochondrial DNA. Clinical manifestation is typically before the age of 40.

    Authors: Tim Sinnecker, Michaela Andelova, Michael Mayr, Stephan Rüegg, Michael Sinnreich, Juergen Hench, Stephan Frank, André Schaller, Christoph Stippich, Jens Wuerfel and Leo H. Bonati

    Citation: BMC Neurology 2019 19:91

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  18. Content type: Research article

    In clinical practice, a large number of post-stroke survivors require nasogastric tube (NGT) placement and nasal feeding for a relatively long period. However, its impact on the swallowing function remains lar...

    Authors: Zhi-Yong Wang, Jian-Min Chen and Guo-Xin Ni

    Citation: BMC Neurology 2019 19:83

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  19. Content type: Research article

    Warfarin is evidence-based therapy for the prevention of cardioembolic stroke, but has not been studied for its effects on whole blood viscosity (WBV). This study investigated the effect of warfarin versus asp...

    Authors: Chan-Hyuk Lee, Keun-Hwa Jung, Daniel J. Cho and Seul-Ki Jeong

    Citation: BMC Neurology 2019 19:82

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  20. Content type: Research article

    Cerebellar hemorrhage is a potentially life-threatening condition and neurologic deterioration during hospitalization could lead to severe disability and poor outcome. Finds out the factors influencing neurolo...

    Authors: Yu-Ni Ho, Shih-Yuan Hsu, Yu-Tsai Lin, Fu-Chang Cheng, Yu-Jun Lin, Nai-Wen Tsai, Cheng-Hsien Lu and Hung-Chen Wang

    Citation: BMC Neurology 2019 19:81

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  21. Content type: Study protocol

    Complex brain arteriovenous malformations (bAVMs) in ≥3 Spetzler-Martin grades have long been challenges among cerebrovascular diseases. None of the traditional methods, such as microsurgical operation, endova...

    Authors: Mingze Wang, Yuming Jiao, Yong Cao, Shuo Wang and Jizong Zhao

    Citation: BMC Neurology 2019 19:75

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  22. Content type: Case report

    Spontaneous isolated posterior inferior cerebellar artery (PICA) dissection has been reported more frequently since high-resolution vessel wall magnetic resonance imaging (HR vw-MRI) was introduced to the fiel...

    Authors: Yong Soo Cho, Pahn Kyu Choi, Hyun Ju Seon, Dong Hun Kim, Byoung-Soo Shin and Hyun Goo Kang

    Citation: BMC Neurology 2019 19:74

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  23. Content type: Research article

    Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial stimulation that has been used to enhance upper limb (UL) motor recovery. However, only limited studies have examined its effica...

    Authors: Yu-Jen Chen, Ying-Zu Huang, Chung-Yao Chen, Chia-Ling Chen, Hsieh-Ching Chen, Ching-Yi Wu, Keh-Chung Lin and Tzu-ling Chang

    Citation: BMC Neurology 2019 19:69

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  24. Content type: Research article

    Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of ma...

    Authors: Ning Gao, Tie Guo, Han Luo, Guolong Tu, Fanglin Niu, Mengdan Yan and Ying Xia

    Citation: BMC Neurology 2019 19:67

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  25. Content type: Research article

    Embolectomy is the standard of care in acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). Aim of this study was to compare two techniques: A Direct Aspiration First Pass Technique (ADAPT) and ...

    Authors: Alex Brehm, Volker Maus, Ioannis Tsogkas, Ruben Colla, Amélie Carolina Hesse, Roland Gerard Gera and Marios-Nikos Psychogios

    Citation: BMC Neurology 2019 19:65

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  26. Content type: Research article

    The effect of the blood urea nitrogen (BUN) to creatinine (Cr) ratio (henceforth BUN/Cr) on haemorrhagic transformation (HT) of acute ischaemic stroke (AIS) patients is unclear.

    Authors: Linghui Deng, Shi Qiu, Changyi Wang, Haiyang Bian, Lu Wang, Yuxiao Li, Bo Wu and Ming Liu

    Citation: BMC Neurology 2019 19:63

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  27. Content type: Research article

    Serum triiodothyronine (T3) concentration was reported to be associated with the prognosis after acute ischemic stroke. The aim of this study was to evaluate the effect of age on the prognostic value of thyroi...

    Authors: Lei-Qing Li, Xiao-Yan Xu, Wen-Yu Li, Xing-Yue Hu and Wen Lv

    Citation: BMC Neurology 2019 19:54

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  28. Content type: Case report

    Carotid rete mirabile (RM) is a meshwork of multiple, freely intercommunicating arterioles that reconstitute the absent or hypoplastic segments of the internal carotid artery (ICA). Carotid RM has been reporte...

    Authors: Hao Chen, Kun Hou, Xin Wang, Kan Xu and Jinlu Yu

    Citation: BMC Neurology 2019 19:51

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  29. Content type: Research article

    The genetic risk factors for carotid stenosis are not fully understood. The aim of this study is to investigate the relationship between variants in platelet activation-relevant genes and carotid stenosis in p...

    Authors: Xingyang Yi, Jing Lin, Qiang Zhou, Ruyue Huang and Zhenxiao Chai

    Citation: BMC Neurology 2019 19:44

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  30. Content type: Case report

    Dural arteriovenous fistula (DAVF) is an uncommon subtype among the intracranial arteriovenous malformations, which is characterized by pathological anastomoses between meningeal arteries and dural venous sinu...

    Authors: Guichen Li, Yang Zhang, Jinchuan Zhao, Xiaobo Zhu, Jinlu Yu and Kun Hou

    Citation: BMC Neurology 2019 19:43

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  31. Content type: Research article

    The efficacy of early supported discharge (ESD) has not been tested in current stroke care setting, which provide relatively short hospital stays, access to hyper-acute therapies and early carotid stenosis int...

    Authors: Anna Bråndal, Marie Eriksson, Eva-Lotta Glader and Per Wester

    Citation: BMC Neurology 2019 19:40

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  32. Content type: Study protocol

    After discharge from hospital following a stroke, prescriptions of community-based rehabilitation are often downgraded to “maintenance” rehabilitation or discontinued. This classic therapeutic behavior stems f...

    Authors: Jean-Michel Gracies, Maud Pradines, Mouna Ghédira, Catherine-Marie Loche, Valentina Mardale, Catherine Hennegrave, Caroline Gault-Colas, Etienne Audureau, Emilie Hutin, Marjolaine Baude and Nicolas Bayle

    Citation: BMC Neurology 2019 19:39

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  33. Content type: Case report

    Moyamoya vasculopathy (MMV) associated with Graves’ disease (GD) is a rare condition resulting in ischemic stroke accompanied by thyrotoxicity. Radiological findings of vasculitis have been reported in the wal...

    Authors: Hiroto Ito, Syunsuke Yokoi, Kinya Yokoyama, Takumi Asai, Kenji Uda, Yoshio Araki, Syuntaro Takasu, Rei Kobayashi, Hisashi Okada and Satoshi Okuda

    Citation: BMC Neurology 2019 19:34

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  34. Content type: Research article

    Ischemic stroke is a leading cause of mortality and morbidity worldwide. Stenosis or blockage of an artery from atherosclerosis can cause insufficient cerebral blood supply, which leads to ischemic stroke. It ...

    Authors: Yan Jiang, Xiaomin Liu, Yifeng Du and Shengnian Zhou

    Citation: BMC Neurology 2019 19:31

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  35. Content type: Case report

    Mixed cerebrovascular disease is a diagnostic entity that presents with hemorrhagic and ischemic stroke clinically and/or subclinically. Here, we report a patient with mixed vascular risk factors, who presente...

    Authors: Dian He, YunLi Yu, Shan Wu, ShuFen Tian, Hui Yu, Shu Xu and Lan Chu

    Citation: BMC Neurology 2019 19:26

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  36. Content type: Research article

    Atrial fibrillation (AF) is present in 15–20% of patients with acute ischemic stroke. Oral anticoagulation reduces the risk of AF-related recurrent stroke but clinical guideline recommendations are rather vagu...

    Authors: Alexander Wutzler, Christos Krogias, Anna Grau, Roland Veltkamp, Peter U. Heuschmann and Karl Georg Haeusler

    Citation: BMC Neurology 2019 19:25

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  37. Content type: Study protocol

    Malnutrition is one of the crucial factors associated with poor prognosis in critical ill patients, yet a significant evidence gap surrounds the management of initial enteral feeding in severe stroke. The Opti...

    Authors: Fang Yuan, Fang Yang, Wei Zhang, Yi Jia, Yaling Ma, Yongcai Qu, Xinglai Wang, Kang Huo, Chengkai Wang, Xiangjun Yuan, Chaohui Song, Bei Zhang and Wen Jiang

    Citation: BMC Neurology 2019 19:24

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  38. Content type: Research article

    Endothelial progenitor cells (EPCs) play an important role in ischemic stroke. However, there are few studies on the relationship between EPC and nondisabling ischemic cerebrovascular events. Our aim was to in...

    Authors: Wang Zhao, Libo Zhao, Juan Liao, Yong Luo and Lanying He

    Citation: BMC Neurology 2019 19:22

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  39. Content type: Research article

    The burden of hospital readmission after stroke is substantial, but little knowledge exists on factors associated with long-term readmission after stroke. In a cohort comprising patients with ischemic stroke a...

    Authors: Anna Therese Bjerkreim, Halvor Naess, Andrej Netland Khanevski, Lars Thomassen, Ulrike Waje-Andreassen and Nicola Logallo

    Citation: BMC Neurology 2019 19:15

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  40. Content type: Case report

    The signs and symptoms of acute alcohol intoxication resemble those of vertebrobasilar stroke. Due to their shared symptoms including double vision, nystagmus, dysarthria, and ataxia, the differential diagnosi...

    Authors: Tamas Arokszallasi, Eszter Balogh, Laszlo Csiba, Istvan Fekete, Klara Fekete and Laszlo Olah

    Citation: BMC Neurology 2019 19:14

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  41. Content type: Research article

    Futile reperfusion (poor functional status despite successful reperfusion) was observed in up to 67% of patients enrolled in recent endovascular treatment (EVT) clinical trials. We investigated the impact of b...

    Authors: Sang-Hwa Lee, Beom Joon Kim, Moon-Ku Han, Tai Hwan Park, Kyung Bok Lee, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Jae Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Jun Lee, Soo Joo Lee, Jae Guk Kim, Jong-Moo Park, Kyusik Kang…

    Citation: BMC Neurology 2019 19:11

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  42. Content type: Research article

    Single acute infarction (SAI) usually had lower risk of stroke recurrence than multiple acute infarctions (MAIs) in minor stroke. To evaluate whether all SAI had lower risk of stroke recurrence than MAIs in mi...

    Authors: Guangyao Wang, Jing Jing, Yuesong Pan, Xia Meng, Xingquan Zhao, Liping Liu, Hao Li, David Wang, Yongjun Wang and Yilong Wang

    Citation: BMC Neurology 2019 19:7

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  43. Content type: Research article

    Transient ischemic attack (TIA) is a risk factor of stroke. Modern treatment regimens and changing risk factors in the population justify new estimates of stroke risk after TIA, and evaluation of the recommend...

    Authors: Fredrik Ildstad, Hanne Ellekjær, Torgeir Wethal, Stian Lydersen, Janne Kutschera Sund, Hild Fjærtoft, Stephan Schüler, Jens Wilhelm Horn, Geir Bråthen, Ann-Grete Midtsæther, Åse Hagen Morsund, Marja-Liisa Lillebø, Yngve Müller Seljeseth and Bent Indredavik

    Citation: BMC Neurology 2019 19:2

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  44. Content type: Research article

    Unplanned readmission within 31 days of discharge after stroke is a useful indicator for monitoring quality of hospital care. We evaluated the risk factors associated with 31-day unplanned readmission of strok...

    Authors: Tiancai Wen, Baoyan Liu, Xia Wan, Xiaoping Zhang, Jin Zhang, Xuezhong Zhou, Alexander Y. L. Lau and Yanning Zhang

    Citation: BMC Neurology 2018 18:218

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