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Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Content type: Research article

    Cerebrospinal fluid (CSF) biomarkers reflect ongoing processes in the brain. Growth-associated protein 43 (GAP-43) is highly upregulated in brain tissue shortly after experimental ischemia suggesting the CSF G...

    Authors: Åsa Sandelius, Nicholas C. Cullen, Åsa Källén, Lars Rosengren, Crister Jensen, Vesna Kostanjevecki, Manu Vandijck, Henrik Zetterberg and Kaj Blennow

    Citation: BMC Neurology 2018 18:202

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  2. Content type: Research article

    Elevated plasma homocysteine (Hcy) is an independent risk factor for ischemic stroke. This study aimed to evaluate the association between Hcy levels and intracranial plaque characteristics and to investigate ...

    Authors: Shan shan Lu, Jun Xie, Chun qiu Su, Song Ge, Hai bin Shi and Xun ning Hong

    Citation: BMC Neurology 2018 18:200

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  3. Content type: Research article

    Warfarin therapies not only are used to prevent stroke in patients with high risk of cardioembolism such as patients with atrial fibrillation (AF) and rheumatic heart disease (RHD), but also was associated wit...

    Authors: Jiaying Zhu, Mengmeng Ma, Yijia Guo, Muke Zhou, Jian Guo and Li He

    Citation: BMC Neurology 2018 18:194

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  4. Content type: Case report

    The majority of ruptured intracranial aneurysms are combined with subarachnoid hemorrhage, but patients with only intracerebral hematoma without any subarachnoid hemorrhage are extremely rare.

    Authors: Guangyong Chen, Meiling Xu, Long Ma, Yufei Gao, Chengyan He and Jinnan Zhang

    Citation: BMC Neurology 2018 18:197

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  5. Content type: Study protocol

    Early and late onset post-stroke cognitive impairment (PCI) contributes substantially to disability following stroke, and is a high priority within stroke research. The aetiology for PCI is complex and related...

    Authors: Pernille Thingstad, Torunn Askim, Mona K. Beyer, Geir Bråthen, Hanne Ellekjær, Hege Ihle-Hansen, Anne Brita Knapskog, Stian Lydersen, Ragnhild Munthe-Kaas, Halvor Næss, Sarah T. Pendlebury, Yngve Muller Seljeseth and Ingvild Saltvedt

    Citation: BMC Neurology 2018 18:193

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  6. Content type: Research article

    There is limited data on the effects of medication-related adverse events occurring during inpatient stays for stroke. The objectives of our study were to characterize reasons for acute readmission after acute...

    Authors: James A. G. Crispo, Dylan P. Thibault, Yannick Fortin, Daniel Krewski and Allison W. Willis

    Citation: BMC Neurology 2018 18:192

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  7. Content type: Study protocol

    Patients with ischaemic stroke or transient ischaemic attack (TIA) are at high risk of future cardiovascular events. Despite compelling evidence about the efficacy of secondary prevention, a substantial gap ex...

    Authors: Thomas Toell, Christian Boehme, Lukas Mayer, Stefan Krebs, Clemens Lang, Karin Willeit, Barbara Prantl, Michael Knoflach, Gerhard Rumpold, Gudrun Schoenherr, Andrea Griesmacher, Peter Willeit, Julia Ferrari, Wilfried Lang, Stefan Kiechl and Johann Willeit

    Citation: BMC Neurology 2018 18:187

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  8. Content type: Research article

    Physical activity (PA) is associated with lower risk of stroke. We tested the hypothesis that lack of pre-stroke PA is an independent predictor of poor outcome after first-ever ischemic stroke.

    Authors: Christian Urbanek, Viola Gokel, Anton Safer, Heiko Becher, Armin J. Grau, Florian Buggle and Frederick Palm

    Citation: BMC Neurology 2018 18:181

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  9. Content type: Research article

    About 30% of stroke patients suffer from aphasia. As aphasia strongly affects daily life, most patients request a prediction of outcome of their language function. Prognostic models provide predictions of outc...

    Authors: Femke Nouwens, Evy G. Visch-Brink, Hanane El Hachioui, Hester F. Lingsma, Mieke W. M. E. van de Sandt-Koenderman, Diederik W. J. Dippel, Peter J. Koudstaal and Lonneke M. L. de Lau

    Citation: BMC Neurology 2018 18:170

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  10. Content type: Research article

    Recent studies have shown conflicting results regarding the effect of hydrogel coils for treating intracranial aneurysm compared to bare platinum coils. We implemented a meta-analysis to assess the value of hy...

    Authors: Tao Xue, Zhouqing Chen, Weiwei Lin, Jiayi Xu, Xuming Shen and Zhong Wang

    Citation: BMC Neurology 2018 18:167

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  11. Content type: Research article

    Studying the impact of demographic changes and progress in the management of stroke patients is necessary in order to organize care structures for the coming years. Consequently, we analyzed the prognostic tre...

    Authors: Emilio Rodríguez-Castro, Iria López-Dequit, María Santamaría-Cadavid, Susana Arias-Rivas, Manuel Rodríguez-Yáñez, José Manuel Pumar, Pablo Hervella, Esteban López-Arias, Andrés da Silva-Candal, Ana Estany, María Piñeiro-Lamas, Tomás Sobrino, Francisco Campos, Manuel Portela, Manuel Vázquez-Lima, José Castillo…

    Citation: BMC Neurology 2018 18:164

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  12. Content type: Case report

    Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurologic...

    Authors: Tongtao Zhao, Gang Wang, Jiaman Dai, Yong Liu, Yi Wang and Shiying Li

    Citation: BMC Neurology 2018 18:159

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  13. Content type: Case report

    The computed tomography (CT) finding of a pseudo-subarachnoid hemorrhage (SAH) may lead the treating physician into a diagnostic dilemma. We present a case of a pseudo-SAH in a patient with post-resuscitative ...

    Authors: Mohamad Syafeeq Faeez Md Noh and Anna Misyail Abdul Rashid

    Citation: BMC Neurology 2018 18:157

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  14. Content type: Research article

    Though genetic and environmental determinants of systemic haemodynamic have been reported, surprisingly little is known about their influences on cerebral haemodynamics. We assessed the potential geographical ...

    Authors: Angela S. M. Salinet, Ronney B. Panerai, Juliana Caldas, Ricardo C. Nogueira, Adriana B. Conforto, Manoel J. Texeira, Edson Bor-Seng-Shu and Thompson G. Robinson

    Citation: BMC Neurology 2018 18:156

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  15. Content type: Research article

    Strategies are needed to improve adherence to the blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) level recommendations after stroke and transient ischemic attack (TIA). We investigated whe...

    Authors: Joachim Ögren, Anna-Lotta Irewall, Lars Söderström and Thomas Mooe

    Citation: BMC Neurology 2018 18:153

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  16. Content type: Research article

    Patients with ischemic cerebrovascular diseases are more likely to suffer from intracranial aneurysms, and their surgical treatment has a growing controversy in this condition. The current case series was aime...

    Authors: Yangrui Zheng and Chen Wu

    Citation: BMC Neurology 2018 18:142

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  17. Content type: Research article

    Various outcome measures are used for the assessment of balance and mobility in patients with stroke. The purpose of the present study was to examine test-retest reliability, construct validity, and responsive...

    Authors: Ahmad H. Alghadir, Einas S. Al-Eisa, Shahnawaz Anwer and Bibhuti Sarkar

    Citation: BMC Neurology 2018 18:141

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  18. Content type: Case report

    Rheumatoid meningitis presenting with a stroke-like attack (RMSA) is a rare manifestation of rheumatoid arthritis (RA). When the patients arrive within the time-window for recombinant tissue plasminogen activa...

    Authors: Masashi Akamatsu, Futaba Maki, Hisanao Akiyama, Daisuke Hara, Masashi Hoshino and Yasuhiro Hasegawa

    Citation: BMC Neurology 2018 18:139

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  19. Content type: Research article

    Early mobilization has been an important part of acute stroke unit treatment. However, early and intense mobilization within the first 24 h post stroke may cause an unfavorable outcome. Recently, objective mea...

    Authors: Ole Petter Norvang, Anne Hokstad, Kristin Taraldsen, Xiangchun Tan, Stian Lydersen, Bent Indredavik and Torunn Askim

    Citation: BMC Neurology 2018 18:138

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  20. Content type: Research article

    Recently, minimal invasive surgery (MIS) has been applied as a common therapeutic approach for treatment of hypertensive intracerebral hemorrhage (HICH). However, the efficacy and safety of MIS is still contro...

    Authors: Yiping Tang, Fengqiong Yin, Dengli Fu, Xinhai Gao, Zhengchao Lv and Xuetao Li

    Citation: BMC Neurology 2018 18:136

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  21. Content type: Research article

    Our aim was to compare the perioperative time courses of matrix metalloproteinase-9 (MMP-9) and its inhibitor (TIMP-1) in during carotid endarterectomy (CEA) and carotid artery stenting (CAS).

    Authors: Ákos Mérei, Bálint Nagy, Gábor Woth, János Lantos, Ferenc Kövér, Lajos Bogár and Diána Mühl

    Citation: BMC Neurology 2018 18:128

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  22. Content type: Research article

    The SPAN-100 index adds patient age and baseline NIHSS-score and was introduced to predict clinical outcome after acute ischemic stroke (AIS). Even with high NIHSS-scores younger patients cannot reach a SPAN-1...

    Authors: Cornelia Möbius, Christian Blinzler, Stefan Schwab, Martin Köhrmann and Lorenz Breuer

    Citation: BMC Neurology 2018 18:129

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  23. Content type: Case report

    Benign gynecologic tumor, such as uterine adenomyosis, has been suggested to develop hypercoagulability. Although some cases of cerebral infarction associated with adenomyosis have been reported, the mechanism...

    Authors: Yasuhiro Aso, Ryo Chikazawa, Yuki Kimura, Noriyuki Kimura and Etsuro Matsubara

    Citation: BMC Neurology 2018 18:119

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  24. Content type: Research article

    Insulin-like growth factor I (IGF-I) has neuroprotective effects in experimental ischemic stroke (IS). However, in patients who have suffered IS, various associations between the levels of serum IGF-I (s-IGF-I...

    Authors: N. David Åberg, Daniel Åberg, Katarina Jood, Michael Nilsson, Christian Blomstrand, H. Georg Kuhn, Johan Svensson, Christina Jern and Jörgen Isgaard

    Citation: BMC Neurology 2018 18:106

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  25. Content type: Study protocol

    After stroke, spasticity of the rectus femoris (RF) and triceps surae (TS) muscles frequently alters the gait pattern. Knee flexion and ankle dorsiflexion in swing are often reduced, respectively called Stiff ...

    Authors: Anthony Supiot, Maxime Geiger, Djamel Bensmail, Phillippe Aegerter, Didier Pradon and Nicolas Roche

    Citation: BMC Neurology 2018 18:104

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  26. Content type: Research article

    Brief measures of health-related quality of life (HRQOL) that assess both patient-reported functioning and well-being after stroke are scarce. The objective of this study was to examine reliability and validit...

    Authors: Guri Heiberg, Synne Garder Pedersen, Oddgeir Friborg, Jørgen Feldbæk Nielsen, Henriette Stabel Holm, Nicole Steinbüchel von, Cathrine Arntzen and Audny Anke

    Citation: BMC Neurology 2018 18:98

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  27. Content type: Research article

    Young ischemic stroke patients are common while classification and analysis based upon imaging characteristics are rarely reported. We intend to compare the clinical and MRI characteristics of cerebral stroke ...

    Authors: Zhang-Ning Zhao, Xiao-Lin Li, Jin-Zhi Liu, Zhi-Ming Jiang and Ai-Hua Wang

    Citation: BMC Neurology 2018 18:87

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  28. Content type: Research article

    The plaques at the dorsal or lateral wall of basilar artery (BA) are associated with pontine infarcts. We sought to explore the correlations between vertebrobasilar artery geometry and BA plaque locations.

    Authors: Jin Yu, Shu Zhang, Ming-Li Li, Yi Ma, Yu-Ru Dong, Min Lou, Feng Feng, Shan Gao, Shi-Wen Wu and Wei-Hai Xu

    Citation: BMC Neurology 2018 18:83

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  29. Content type: Research article

    There is uncertainty regarding the effect of anemia and red blood cell transfusion on functional outcome following acute ischemic stroke. We studied the relationship of hemoglobin parameters and red cell trans...

    Authors: Kartavya Sharma, Daniel J. Johnson, Brenda Johnson, Steven M. Frank and Robert D. Stevens

    Citation: BMC Neurology 2018 18:78

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  30. Content type: Case report

    Cervical artery dissection is one of the most important causes of ischemic stroke in young age patients. However, multiple cervical artery dissection simultaneously involving the anterior and posterior circula...

    Authors: Sung eun Chung, Tae Hwan Yoon, Kyung Mi Lee, Hyug-Gi Kim and Bum Joon Kim

    Citation: BMC Neurology 2018 18:74

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  31. Content type: Research article

    Epilepsy is a major complication of stroke. We aimed to establish whether there is an association between intravenous thrombolysis, intra-arterial thrombolysis and post stroke seizure (PSS) development. Improv...

    Authors: Jillian Naylor, Arthur Thevathasan, Leonid Churilov, Ruibing Guo, Yunyun Xiong, Miriam Koome, Ziyi Chen, Ziyuan Chen, Xinfeng Liu, Patrick Kwan and Bruce C. V. Campbell

    Citation: BMC Neurology 2018 18:61

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  32. Content type: Research article

    Endovascular techniques have proven beneficial in the treatment of aneurysmal subarachnoid hemorrhage (aSAH), but with high risk of arterial clotting, emboli and dissection. Platelet activation and alterations...

    Authors: Pauline Perez, Anne-Claire Lukaszewicz, Stephanie Lenck, Rémy Nizard, Ludovic Drouet and Didier Payen

    Citation: BMC Neurology 2018 18:57

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  33. Content type: Research article

    Caregiver burden may be either a predictor or an outcome of caregiver quality of life (QoL). Patient or caregiver factors that directly affect caregiver QoL, predictors that are simultaneously shared with care...

    Authors: Yu-Hsia Tsai, Meei-Fang Lou, Tsui-Hsia Feng, Tsung-Lan Chu, Ying-Jen Chen and Hsueh-Erh Liu

    Citation: BMC Neurology 2018 18:50

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  34. Content type: Research article

    It is usually difficult to identify stroke pathogenesis for single lenticulostriate infarction with nonstenotic middle cerebral artery (MCA). Our aim is to differentiate the two pathogeneses, non-branch athero...

    Authors: Li-Li Sun, Zhong-Hao Li, Wen-Xiong Tang, Lei Liu, Fei-Yan Chang, Xue-Bin Zhang, Wei-Jie Ye, Shuo Lu, Zun-Jing Liu and Xian-Jin Zhu

    Citation: BMC Neurology 2018 18:51

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  35. Content type: Case report

    Vertebrobasilar dolichoectasia (VBD) is a clinical entity associated with ischemic stroke, compression of cranial nerves or brainstem, and hydrocephalus. There have been relatively few studies following the pr...

    Authors: Dao Pei Zhang, Yan Fang Peng, Qian Kun Ma, Min Zhao, Huai Liang Zhang and Suo Yin

    Citation: BMC Neurology 2018 18:45

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  36. Content type: Case report

    Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction ...

    Authors: Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama and Michiyasu Suzuki

    Citation: BMC Neurology 2018 18:42

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  37. Content type: Study protocol

    Stroke survivors are more physically inactive than even the most sedentary older adults, and low activity is associated with increased risk of recurrent stroke, medical complications, and mortality. We hypothe...

    Authors: Henry Wright, Tamara Wright, Ryan T. Pohlig, Scott E. Kasner, Jonathan Raser-Schramm and Darcy Reisman

    Citation: BMC Neurology 2018 18:39

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  38. Content type: Case report

    Transient global amnesia is reported to be caused by cerebral venous congestion. Internal jugular venous flow reversal in particular with the Valsalva maneuver leads to cerebral venous congestion. In addition,...

    Authors: Yuta Maetani, Masahiro Nakamori, Tomoaki Watanabe, Hayato Matsushima, Eiji Imamura and Shinichi Wakabayashi

    Citation: BMC Neurology 2018 18:36

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  39. Content type: Research article

    Intravenous tissue plasminogen activator (IV tPA) after acute ischemic stroke carries the risk of symptomatic intracerebral hemorrhage (sICH). Cerebral microbleeds (CMBs) may indicate increased risk of hemorrh...

    Authors: Martin A. Chacon-Portillo, Rafael H. Llinas and Elisabeth B. Marsh

    Citation: BMC Neurology 2018 18:33

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  40. Content type: Research article

    There have been found apoptotic changes in brain tissue samples from humans after cerebral ischemia. Caspase-cleaved cytokeratin (CCCK)-18 could appears in blood during apoptosis. High circulating levels of CC...

    Authors: Leonardo Lorente, María M. Martín, Antonia Pérez-Cejas, Luis Ramos, Mónica Argueso, Jordi Solé-Violán, Juan J. Cáceres, Alejandro Jiménez and Victor García-Marín

    Citation: BMC Neurology 2018 18:32

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  41. Content type: Study protocol

    Intracerebral hemorrhage is a devastating disease with no specific treatment modalities. A significant proportion of patients with intracerebral hemorrhage are transferred to large stroke treatment centers, su...

    Authors: Farhaan S. Vahidy, Ellie G. Meyer, Arvind B. Bambhroliya, Jennifer R. Meeks, Charles E. Begley, Tzu-Ching Wu, Jon E. Tyson, Charles C. Miller, Ritvij Bowry, Wamda O. Ahmed, Gretchel A. Gealogo, Louise D. McCullough, Steven Warach and Sean I. Savitz

    Citation: BMC Neurology 2018 18:31

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  42. Content type: Research article

    A significant proportion of patients with mild ischemic stroke become disabled despite receiving intravenous thrombolytic therapy. The purpose of this study was to assess the clinical and radiological factors ...

    Authors: Dae-Hyun Kim, Deok-Soo Lee, Hyun-Wook Nah and Jae-Kwan Cha

    Citation: BMC Neurology 2018 18:30

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  43. Content type: Research article

    Prognostic models have been increasingly developed to predict complete recovery in ischemic stroke. However, questions arise about the performance characteristics of these models. The aim of this study was to ...

    Authors: Nampet Jampathong, Malinee Laopaiboon, Siwanon Rattanakanokchai and Porjai Pattanittum

    Citation: BMC Neurology 2018 18:26

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  44. Content type: Research article

    Chronic kidney disease increases stroke incidence and severity but the mechanisms behind this cerebro-renal interaction are mostly unexplored. Since both vascular beds share similar features, microvascular dys...

    Authors: Pedro Castro, Elsa Azevedo, Isabel Rocha, Farzaneh Sorond and Jorge M. Serrador

    Citation: BMC Neurology 2018 18:21

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  45. Content type: Research article

    Clinical scales to detect large vessel occlusion (LVO) may help to determine the optimal transport destination for patients with suspected acute ischemic stroke (AIS). The clinical benefit associated with impr...

    Authors: Ludwig Schlemm and Eckhard Schlemm

    Citation: BMC Neurology 2018 18:16

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