Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Study protocol

    Research on advanced intervention using novel bone marrOW stem cell (RAINBOW): a study protocol for a phase I, open-label, uncontrolled, dose-response trial of autologous bone marrow stromal cell transplantation in patients with acute ischemic stroke

    Stroke is a leading cause of death and disability, and despite intensive research, few treatment options exist. However, a recent breakthrough in cell therapy is expected to reverse the neurological sequelae o...

    Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, Tuyoshi Teramoto, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Shunsuke Terasaka, Teruyo Arato and Kiyohiro Houkin

    BMC Neurology 2017 17:179

    Published on: 8 September 2017

  2. Research article

    Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke

    While neurogranin has no value as plasma biomarker for Alzheimer’s disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin l...

    Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs and Eugeen Vanmechelen

    BMC Neurology 2017 17:170

    Published on: 30 August 2017

  3. Research article

    Clinical features and the degree of cerebrovascular stenosis in different types and subtypes of cerebral watershed infarction

    Whether there are differences in pathogenesis among different types and subtypes of cerebral watershed infarction (WSI) is controversial since they have been combined into a single group in most previous studies.

    Yue Li, Man Li, Xiaoyu Zhang, Shuna Yang, Huimin Fan, Wei Qin, Lei Yang, Junliang Yuan and Wenli Hu

    BMC Neurology 2017 17:166

    Published on: 29 August 2017

  4. Research article

    Cilostazol improves endothelial function in acute cerebral ischemia patients: a double-blind placebo controlled trial with flow-mediated dilation technique

    In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.

    Seong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin and Ji Man Hong

    BMC Neurology 2017 17:169

    Published on: 29 August 2017

  5. Research article

    Feasibility and diagnostic accuracy of point-of-care handheld echocardiography in acute ischemic stroke patients – a pilot study

    Standard echocardiography (SE) is an essential part of the routine diagnostic work-up after ischemic stroke (IS) and also serves for research purposes. However, access to SE is often limited. We aimed to asses...

    Peter Kraft, Anna Fleischer, Silke Wiedmann, Viktoria Rücker, Daniel Mackenrodt, Caroline Morbach, Uwe Malzahn, Christoph Kleinschnitz, Stefan Störk and Peter U. Heuschmann

    BMC Neurology 2017 17:159

    Published on: 11 August 2017

  6. Research article

    Prevalence of and risk factors for enlarged perivascular spaces in adult patients with moyamoya disease

    Enlarged perivascular spaces (EPVS) are often observed with magnetic resonance imaging in patients with small vessel disease. However, the risk factors, radiological features, and clinical relevance of EPVS in...

    Tomoyoshi Kuribara, Takeshi Mikami, Katsuya Komatsu, Hime Suzuki, Hirofumi Ohnishi, Kiyohiro Houkin and Nobuhiro Mikuni

    BMC Neurology 2017 17:149

    Published on: 4 August 2017

  7. Research article

    Prevalence and risk factors of intracranial and extracranial artery stenosis in asymptomatic rural residents of 13 villages in China

    The present study aimed to investigate the prevalence and risk factors for extracranial carotid artery stenosis (ECAS) and intracranial carotid artery stenosis (ICAS) simultaneously in asymptomatic Chinese pur...

    Haiqiang Jin, Qing Peng, Ding Nan, Pu Lv, Ran Liu, Wei Sun, Yuming Teng, Yuanyuan Liu, Chenghe Fan, Haiying Xing, Ke Xu and Yining Huang

    BMC Neurology 2017 17:136

    Published on: 18 July 2017

  8. Study protocol

    The Comprehensive Post-Acute Stroke Services (COMPASS) study: design and methods for a cluster-randomized pragmatic trial

    Patients discharged home after stroke face significant challenges managing residual neurological deficits, secondary prevention, and pre-existing chronic conditions. Post-discharge care is often fragmented lea...

    Pamela W. Duncan, Cheryl D. Bushnell, Wayne D. Rosamond, Sara B. Jones Berkeley, Sabina B. Gesell, Ralph B. D’Agostino Jr, Walter T. Ambrosius, Blair Barton-Percival, Janet Prvu Bettger, Sylvia W. Coleman, Doyle M. Cummings, Janet K. Freburger, Jacqueline Halladay, Anna M. Johnson, Anna M. Kucharska-Newton, Gladys Lundy-Lamm…

    BMC Neurology 2017 17:133

    Published on: 17 July 2017

  9. Research article

    Predictors of intensive care unit admission and mortality in patients with ischemic stroke: investigating the effects of a pulmonary rehabilitation program

    The aim of this study was to investigate the predictors of intensive care unit (ICU) admission and mortality among stroke patients and the effects of a pulmonary rehabilitation program on stroke patients.

    Belma Doğan Güngen, Abdulkadir Tunç, Yeşim Güzey Aras, Aslı Aksoy Gündoğdu, Adil Can Güngen and Serdar Bal

    BMC Neurology 2017 17:132

    Published on: 11 July 2017

  10. Research article

    Nasal administration of the neuroprotective candidate NeuroEPO to healthy volunteers: a randomized, parallel, open-label safety study

    Delivery of therapeutic agents as erythropoietin (EPO) into Central Nervous System through intranasal route could benefit patients with neurological disorders. A new nasal formulation containing a non-hematopo...

    Orestes Santos-Morales, Alina Díaz-Machado, Daise Jiménez-Rodríguez, Yaisel Pomares-Iturralde, Tatiana Festary-Casanovas, Carlos A. González-Delgado, Sonia Pérez-Rodríguez, Eulalia Alfonso-Muñoz, Carmen Viada-González, Patricia Piedra-Sierra, Idrian García-García, Daniel Amaro-González, Julio César García-Rodríguez, Iliana Sosa-Testé, Alicia Lagarto-Parra, Laura Barrero-Viera…

    BMC Neurology 2017 17:129

    Published on: 4 July 2017

  11. Case report

    Thrombocytopenia induced by dabigatran: two case reports

    Vitamin K inhibitors (e.g. warfarin) and indirect thrombin inhibitors (e.g. heparin) are widely used to prevent thromboembolic disorders (e.g. myocardial infarction, venous thromboembolism, and stroke). These ...

    Hyun Goo Kang, Seung Jae Lee, Ji Yeon Chung and Jin Sung Cheong

    BMC Neurology 2017 17:124

    Published on: 29 June 2017

  12. Research article

    Current smoking is associated with extracranial carotid atherosclerotic stenosis but not with intracranial large artery disease

    Accumulating evidence has shown that cigarette smoking is an important risk factor for ischemic stroke. However, it is not clear about the potential mechanisms through which cigarette smoking affects stroke ri...

    Ruijun Ji, Yuesong Pan, Hongyi Yan, Runhua Zhang, Gaifen Liu, Penglian Wang, Yilong Wang, Hao Li, Xingquan Zhao and Yongjun Wang

    BMC Neurology 2017 17:120

    Published on: 26 June 2017

  13. Database

    Validation of an International Classification of Disease, Ninth Revision coding algorithm to identify decompressive craniectomy for stroke

    Although International Classification of Disease, Ninth Revision, Clinical Modification (ICD9-CM) coding is the basis of administrative claims data, no study has validated an ICD9-CM algorithm to identify patient...

    Hormuzdiyar H. Dasenbrock, David J. Cote, Yuri Pompeu, Viren S. Vasudeva, Timothy R. Smith and William B. Gormley

    BMC Neurology 2017 17:121

    Published on: 26 June 2017

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