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Cerebrovascular disease and stroke

Section edited by Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Transient ischemic attack (TIA) patients are at high risk of recurrent vascular events; timely management can reduce that risk by 70%. The Protocol-guided Rapid Evaluation of Veterans Experiencing New Transien...

    Authors: D. M. Bravata, L. J. Myers, B. Homoya, E. J. Miech, N. A. Rattray, A. J. Perkins, Y. Zhang, J. Ferguson, J. Myers, A. J. Cheatham, L. Murphy, B. Giacherio, M. Kumar, E. Cheng, D. A. Levine, J. J. Sico…

    Citation: BMC Neurology 2019 19:294

    Content type: Study protocol

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  2. Neurological disorders are an economic and public health burden which requires efficient and adequate medical resources. Currently, little is known about the status of the quality of neurological care services...

    Authors: Jun-Fang Zhang, Meng-Yao Qiu, Yu-Lei Zhang, Xi-Xi Wang, Guo-Ping Wang, Yu Geng, Ke-Zhong Zhang, Kan Fang and Yun-Cheng Wu

    Citation: BMC Neurology 2019 19:293

    Content type: Research article

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  3. Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility of ischemic stroke. We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes in order to ...

    Authors: Lei Zhao, Jinghuan Fang, Muke Zhou, Jie Zhou, Lihua Yu, Ning Chen and Li He

    Citation: BMC Neurology 2019 19:291

    Content type: Research article

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  4. Ischemia-reperfusion (I/R)-induced vascular dysfunction is the main factor to acute ischemic stroke. Sirt3 is one of the sirtuin family members, which plays an important role in the development of neurological...

    Authors: Zhenzhen Zhao, Xiaoxiu Zhang, Yuanqiang Dai, Ke Pan, Yu Deng, Yan Meng and Tao Xu

    Citation: BMC Neurology 2019 19:289

    Content type: Research article

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  5. Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis of unknown cause involving the brain and accompanied by prominent eosinophilia. Intracardiac thrombosis is a major cardiac com...

    Authors: Kenichiro Hira, Hideki Shimura, Riyu Kamata, Masashi Takanashi, Akane Hashizume, Keiji Takahashi, Mizuho Sugiyama, Hiroshi Izumi, Nobutaka Hattori and Takao Urabe

    Citation: BMC Neurology 2019 19:288

    Content type: Case report

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  6. Capsular warning syndrome (CWS) is a rare clinical syndrome, which is defined as a recurrent transient lacunar syndrome. The mechanism and clinical management of CWS remain unclear. The aim of the study was to...

    Authors: Lanying He, Ronghua Xu, Jian Wang, Lili Zhang, Lijuan Zhang, Fangfang Zhou and Weiwei Dong

    Citation: BMC Neurology 2019 19:285

    Content type: Research article

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  7. As health behavior varies with increasing age, we aimed to examine the potential barriers in calling emergency medical services (EMS) after recognizing a stroke among 40–74- and 75–99-year-old adults.

    Authors: Shengde Li, Li-Ying Cui, Craig Anderson, Chunpeng Gao, Chengdong Yu, Guangliang Shan, Longde Wang and Bin Peng

    Citation: BMC Neurology 2019 19:283

    Content type: Research article

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  8. Diagnosing dysphagia in acute stroke patients is crucial, as this comorbidity determines morbidity and mortality; we therefore investigated the impact of flexible nasolaryngeal endoscopy (FEES) in acute stroke...

    Authors: Tobias Braun, Martin Juenemann, Maxime Viard, Marco Meyer, Iris Reuter, Mario Prosiegel, Manfred Kaps and Christian Tanislav

    Citation: BMC Neurology 2019 19:282

    Content type: Research article

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  9. Cerebral infarction occurs when the arteries to brain are obstructed, and motor impairment contralateral to responsible lesion is commonly recognized. Few studies have profiled the characteristics of cases wit...

    Authors: Zhe-Ren Tan, Chen Zhang and Fa-Fa Tian

    Citation: BMC Neurology 2019 19:279

    Content type: Research article

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  10. Early supported discharge (ESD) has been shown to be efficient and safe as part of the stroke care pathway. The best results have been seen with a multidisciplinary team and after mild to moderate stroke. Howe...

    Authors: Lena Rafsten, Anna Danielsson, Asa Nordin, Ann Björkdahl, Asa Lundgren-Nilsson, Maria E. H. Larsson and Katharina S. Sunnerhagen

    Citation: BMC Neurology 2019 19:277

    Content type: Research article

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  11. Internal carotid artery dissection has been well recognized as a major cause of ischaemic stroke in young and middle-aged adults. However, internal carotid artery dissection induced hypoglossal nerve palsy has...

    Authors: Zhaoyao Chen, Jun Yuan, Hui Li, Cuiping Yuan, Kailin Yin, Sen Liang, Pengfei Li and Minghua Wu

    Citation: BMC Neurology 2019 19:276

    Content type: Case report

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  12. Early prediction of unfavorable outcome after ischemic stroke is of great significance to the clinical and therapeutic management. A nomogram is a better visual tool than earlier models and prognostic scores t...

    Authors: Chao Sun, Xiang Li, Baili Song, Xiangliang Chen, Linda Nyame, Yukai Liu, Dan Tang, Mako Ibrahim, Zheng Zhao, Chao Liu, Miao Yan, Xiding Pan, Jie Yang, Junshan Zhou and Jianjun Zou

    Citation: BMC Neurology 2019 19:274

    Content type: Research article

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  13. Patients with acute ischemic stroke (AIS) often experience low serum free triiodothyronine (FT3), but the association of low FT3 with stroke severity, subtype and prognosis has not yet been thoroughly studied,...

    Authors: Shanchao Zhang, Xia Zhao, Shan Xu, Jing Yuan, Zhihua Si, Yang Yang, Shan Qiao, Xuxu Xu and Aihua Wang

    Citation: BMC Neurology 2019 19:272

    Content type: Research article

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  14. To study the association of caregiver factors and stroke patient factors with rehospitalizations over the first 3 months and subsequent 3–12 months post-stroke in Singapore.

    Authors: Shilpa Tyagi, Gerald C. H. Koh, Nan Luo, Kelvin B. Tan, Helen Hoenig, David B. Matchar, Joanne Yoong, Angelique Chan, Kim En Lee, N. Venketasubramanian, Edward Menon, Kin Ming Chan, Deidre Anne De Silva, Philip Yap, Boon Yeow Tan, Effie Chew…

    Citation: BMC Neurology 2019 19:267

    Content type: Research article

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  15. Intravenous thrombolysis (IVT) plays a prominent role in the treatment of acute ischemic stroke (AIS). The sooner IVT is administered, the higher the odds of a good outcome. Therefore, registering the in-hospi...

    Authors: Laurien S. Kuhrij, Perla J. Marang-van de Mheen, Renske M. van den Berg-Vos, Frank-Erik de Leeuw and Paul J. Nederkoorn

    Citation: BMC Neurology 2019 19:265

    Content type: Research article

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  16. Failing to recognise the signs and symptoms of subarachnoid haemorrhage (SAH) causes diagnostic delay and may result in poorer outcomes. We report a rare case of SAH secondary to a vertebral artery dissection ...

    Authors: Lloyd Steele, Muhammad Hasan Raza, Richard Perry, Neil Rane and Sophie J. Camp

    Citation: BMC Neurology 2019 19:262

    Content type: Case report

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  17. The aim of this study was to evaluate the correlation between significant asymptomatic carotid artery stenosis (ACAS) and severity of peripheral arterial occlusive disease (PAOD) in the lower limb, and to inve...

    Authors: Zhongjie Pan, Ruitao Wang, Li Li and Hua Zhang

    Citation: BMC Neurology 2019 19:259

    Content type: Research article

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  18. Elevated blood pressure (BP) at emergency department (ED) presentation and advancing age have been associated with risk of ischemic stroke; however, the relationship between BP, age, and transient ischemic att...

    Authors: Andrew M. Penn, Nicole S. Croteau, Kristine Votova, Colin Sedgwick, Robert F. Balshaw, Shelagh B. Coutts, Melanie Penn, Kaitlin Blackwood, Maximilian B. Bibok, Viera Saly, Janka Hegedus, Amy Y. X. Yu, Charlotte Zerna, Evgenia Klourfeld and Mary L. Lesperance

    Citation: BMC Neurology 2019 19:251

    Content type: Research article

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  19. The purpose of this study was to report our preliminary experience of stent-assisted coiling (SAC) of wide-necked intracranial aneurysms with a single microcatheter in patients with parent arteries that were s...

    Authors: Keun Young Park, Chang Ki Jang, Jae Whan Lee, Dong Joon Kim, Byung Moon Kim and Joonho Chung

    Citation: BMC Neurology 2019 19:245

    Content type: Technical advance

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  20. Atrial fibrillation (AF) is a common cause of cerebral infarction, which could lead to endothelial dysfunction, increased reactive oxygen species (ROS) and oxidized low density lipoprotein (Ox-LDL).AF is assoc...

    Authors: Lanying He, Ronghua Xu, Jian Wang, Lili Zhang, Lijuan Zhang, Wang Zhao and Weiwei Dong

    Citation: BMC Neurology 2019 19:240

    Content type: Research article

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  21. Previously there have been found higher circulating malondialdehyde levels during the first week of ischemic stroke in patients with worst neurological functional outcome, and at moment of ischemic stroke in n...

    Authors: Leonardo Lorente, María M. Martín, Pedro Abreu-González, Rafael Sabatel, Luis Ramos, Mónica Argueso, Jordi Solé-Violán, Juan J. Cáceres, Alejandro Jiménez and Victor García-Marín

    Citation: BMC Neurology 2019 19:238

    Content type: Research article

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  22. Brain ischemia activates the parasympathetic cholinergic pathway in animal models of human disease. However, it remains unknown whether activation of the cholinergic pathway impacts immune defenses and disease...

    Authors: Meng Yuan, Bin Han, Yiping Xia, Ye Liu, Chunyang Wang and Chao Zhang

    Citation: BMC Neurology 2019 19:236

    Content type: Research article

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  23. Radiation therapy can cause cerebral arteriopahty, resulting in ischemic stroke. We document late-delayed cerebral arteriopathy by high-resolution magnetic resonance imaging (HR-MRI) in a middle aged man who h...

    Authors: Huan Chen, Xiuhua Li, Xiaoyu Zhang, Wenjuan Xu, Fei Mao, Mengxin Bao and Meijia Zhu

    Citation: BMC Neurology 2019 19:232

    Content type: Case report

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  24. Endovascular treatment (EVT) is advocated for acute ischaemic stroke with large-vessel occlusion (LVO), but perioperative periods are challenging. This study investigated the relationship between post-EVT shor...

    Authors: Tianli Zhang, Xiaolong Wang, Chao Wen, Feng Zhou, Shengwei Gao, Xiaodong Zhang, Shiqin Lin, Jing Shi and Weirong Li

    Citation: BMC Neurology 2019 19:228

    Content type: Research article

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  25. Due to improvements in both the quality and availability of intracranial imaging as well as the evolution of surgical and endovascular techniques during the last decade, the number of treatments of unruptured ...

    Authors: Christin Campe, Jens Neumann, I. Erol Sandalcioglu, Ali Rashidi and Michael Luchtmann

    Citation: BMC Neurology 2019 19:226

    Content type: Case report

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  26. Self-rated health (SRH) allows for comparison and identification of the health status of various populations. The aim of this study was to conduct a systematic review of the literature to expand the understand...

    Authors: Érika de Freitas Araújo, Ramon Távora Viana, Luci Fuscaldi Teixeira-Salmela, Lidiane Andrea Oliveira Lima and Christina Danielli Coelho de Morais Faria

    Citation: BMC Neurology 2019 19:221

    Content type: Research article

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  27. Stroke patients are often affected by long-term disabilities with needs concerning social issues. There is relatively little consideration of social recovery of patients and the support required to return to w...

    Authors: Sophie Lehnerer, Benjamin Hotter, Inken Padberg, Petra Knispel, Dike Remstedt, Andrea Liebenau, Ulrike Grittner, Ian Wellwood and Andreas Meisel

    Citation: BMC Neurology 2019 19:220

    Content type: Research article

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  28. The global burden of stroke epidemiology is changing rapidly. Over the 1990–2013 periods, there was a significant increase in the absolute number of deaths and incident events of stroke. The burden of stroke v...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:213

    Content type: Research article

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  29. Rates of thrombolysis in most countries are well below best practice benchmarks. We aimed to investigate thrombolysis utilization and its associated factors in acute ischemic stroke (AIS) patients in Hubei pro...

    Authors: Yanfeng Zhou, Shijiao Yan, Xingyue Song, Yanhong Gong, Wenzhen Li, Mengdie Wang, Xiaoxv Yin, Bo Hu and Zuxun Lu

    Citation: BMC Neurology 2019 19:202

    Content type: Research article

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  30. Mechanical thrombectomy (MT) using stent retriever assisted vacuum-locked extraction (SAVE) is a promising method for anterior circulation strokes. We present our experience with SAVE for large vessel occlusio...

    Authors: Volker Maus, Hanna Styczen, Jan Liman, Ilko Maier, Alex Brehm, Ioannis Tsogkas and Marios-Nikos Psychogios

    Citation: BMC Neurology 2019 19:197

    Content type: Research article

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  31. Recovery of upper limb function in individuals after a stroke remains challenging. Modified constraint-induced movement therapy (m-CIMT) has strong evidence for increasing the use and recovery of sensorimotor ...

    Authors: Erika Shirley Moreira da Silva, Gabriela Lopes Santos, Aparecida Maria Catai, Alexandra Borstad, Natália Pereira Duarte Furtado, Isabela Arruda Verzola Aniceto and Thiago Luiz Russo

    Citation: BMC Neurology 2019 19:196

    Content type: Study protocol

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    The Correction to this article has been published in BMC Neurology 2019 19:225

  32. Emotional processes and responses are underestimated in stroke patients because the massive clinical picture of large hemispheric strokes often hides these symptoms. We report on a patient with peculiar unplea...

    Authors: Mariagiovanna Cantone, Giuseppe Lanza, Rita Bella, Giovanni Pennisi, Paola Santalucia, Placido Bramanti and Manuela Pennisi

    Citation: BMC Neurology 2019 19:193

    Content type: Case report

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  33. The topographic location of acute pontine infarction is associated with clinical syndromes and prognosis. Previous studies focused on isolated pontine infarction, but the topographic location of unisolated pon...

    Authors: Jiehong Huang, Zhihua Qiu, Piansi Zhou, Jianming Li, Yingxin Chen, Ruiyun Huang, Chujing Li, Xilin Ouyang, Huazhuo Feng, Hanqing Xu, Dezhi Liu, Zheng Dai, Juehua Zhu, Xinfeng Liu, Hongbing Chen and Yongjun Jiang

    Citation: BMC Neurology 2019 19:186

    Content type: Research article

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  34. Stroke is the second-leading global cause of death behind heart disease in 2013 and is a major cause of permanent disability. The burden of stroke in terms of mortality, morbidity and disability is increasing ...

    Authors: Ginenus Fekadu, Legese Chelkeba and Ayantu Kebede

    Citation: BMC Neurology 2019 19:183

    Content type: Research article

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  35. Hypothalamic lesions, such as tumors and demyelinating diseases, reportedly cause abnormal sleepiness. However, stroke involving the hypothalamus has rarely been described. Here, we report a patient with infar...

    Authors: Takeo Matsubara, Keisuke Suzuki, Akiko Kawasaki, Masayuki Miyamoto, Madoka Okamura, Takashi Kanbayashi, Hidehiro Takekawa, Toshiki Nakamura, Yuji Watanabe, Masanori Matsubara and Koichi Hirata

    Citation: BMC Neurology 2019 19:182

    Content type: Case report

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  36. Optimizing thrombolytic therapy is vital for improving stroke outcomes. We aimed to develop standardized thrombolysis conditions to evaluate the efficacy of tenecteplase (TNK) compared to the current gold stan...

    Authors: Tobias Frühwald, Ulrich Gärtner, Nils Stöckmann, Jan-Henning Marxsen, Carolin Gramsch and Florian C. Roessler

    Citation: BMC Neurology 2019 19:181

    Content type: Research article

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  37. This study examined how intracranial large artery stenosis (ILAS), symptomatic and asymptomatic ILAS, and risk factors affect unfavorable outcome events after medical treatment in routine clinical practice.

    Authors: K. C. Chang, I. C. Chuang, Y. C. Huang, C. Y. Wu, W. C. Lin, Y. L. Kuo, T. H. Lee and S. J. Ryu

    Citation: BMC Neurology 2019 19:180

    Content type: Research article

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  38. B-mode and Color Doppler ultrasonography (CDUS) are the methods of choice for screening and determining the degree of Carotid artery stenosis. The evaluation of stenosis with calcification may be hampered by a...

    Authors: Estelle E. Seyman, Natan Bornstein, Eitan Auriel, Oren Cohen, Tania Nissel and Hen Hallevi

    Citation: BMC Neurology 2019 19:178

    Content type: Research article

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  39. Insulin resistance (IR) in relation to diabetes is a risk factor for ischemic stroke (IS), whereas less is known about non-diabetic IR and outcome after IS.

    Authors: Daniel Åberg, N. David Åberg, Katarina Jood, Lukas Holmegaard, Petra Redfors, Christian Blomstrand, Jörgen Isgaard, Christina Jern and Johan Svensson

    Citation: BMC Neurology 2019 19:177

    Content type: Research article

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  40. Elevated levels of plasma D-dimer increase the risk of ischemic stroke, stroke severity, and the progression of stroke status, but the association between plasma D-dimer level and functional outcome is unclear...

    Authors: Tao Yao, Bo-Lin Tian, Gang Li, Qin Cui, Cui-fang Wang, Qi Zhang, Bo Peng, Yan Gao, Yan-Qiang Zhan, Dan Hu, Lu Xu and Gao-Hua Wang

    Citation: BMC Neurology 2019 19:175

    Content type: Research article

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  41. The exact relationship between 25-hydroxyvitamin D [25(OH) D] levels and small vessel disease (SVD) are not clear in China. The aim of this study was to determine such the association between 25(OH) D and SVD ...

    Authors: Junzeng Si, Kuibao Li, Peiyan Shan and Junliang Yuan

    Citation: BMC Neurology 2019 19:164

    Content type: Research article

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  42. Patients with vertebrobasilar dolichoectasia usually have persistent hemodynamic abnormalities, and therefore, may bear an increased risk of stroke. This study aimed to identify risk factors for stroke recurre...

    Authors: Zhaoyao Chen, Shuai Zhang, Zhengze Dai, Xi Cheng, Minghua Wu, Qiliang Dai, Xinfeng Liu and Gelin Xu

    Citation: BMC Neurology 2019 19:163

    Content type: Research article

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  43. Intravenous thrombolysis has been recently introduced in Nepal for the management of acute ischemic stroke. Pre-hospital delay is one of the main reasons that hinder thrombolytic therapy. The objective of this...

    Authors: Gaurav Nepal, Jayant Kumar Yadav, Babin Basnet, Tirtha Man Shrestha, Ghanshyam Kharel and Rajeev Ojha

    Citation: BMC Neurology 2019 19:155

    Content type: Research article

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  44. Simultaneous cerebral and myocardial infarction is called cardiocerebral infarction (CCI), and is rarely encountered. Because of the narrow time window and complex pathophysiology, CCI is challenging to immedi...

    Authors: Soichiro Abe, Kanta Tanaka, Hiroshi Yamagami, Kazutaka Sonoda, Hiroya Hayashi, Shuichi Yoneda, Kazunori Toyoda and Masatoshi Koga

    Citation: BMC Neurology 2019 19:152

    Content type: Case report

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  45. Mechanical thrombectomy has been proven as a standard care for moderate to severe ischemic stroke with anterior large vessel occlusion (LVO); however, whether it is equally effective in mild ischemic stroke (M...

    Authors: Xian-Jin Shang, Zhong-Hua Shi, Cai-Feng He, Shuai Zhang, Yong-Jie Bai, Yong-Tao Guo, Bo Sun, Shun Li, Huai-Ming Wang, Zhi-Ming Zhou, Wen-Jie Zi and Xin-Feng Liu

    Citation: BMC Neurology 2019 19:150

    Content type: Research article

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