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Cerebrovascular disease and stroke

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Presentation with massive systemic embolization as the initial manifestation of occult malignancy is infrequent. The standard management of cancer-related arterial thromboembolism has not yet been established.

    Authors: Zheng Wang, Jiangyong Miao, Lina Wang, Ying Liu, Hui Ji, Xiangjian Zhang and Lili Cui

    Citation: BMC Neurology 2021 21:221

    Content type: Case report

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  2. Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is an adult-onset rare monogenic microvasculopathy. Its typical neuroimaging features are punctate white matter lesio...

    Authors: Yuying Yan, Shuai Jiang, Ruilin Wang, Xiang Wang, Peng Li and Bo Wu

    Citation: BMC Neurology 2021 21:219

    Content type: Case report

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  3. Chronic inflamed tissue in nasal cavity is a rare complication of transsphenoidal approach (TSA). Inflamed tissue is rich in blood vessels, which can lead to frequent nosebleeds. In addition, chronic inflammat...

    Authors: Ja Yoon Kim, Yong Bae Kim and Joonho Chung

    Citation: BMC Neurology 2021 21:215

    Content type: Case report

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  4. Heterogenous central nervous system (CNS) neurologic manifestations of polyarteritis nodosa (PAN) are underrecognized. We review three cases of patients with PAN that illustrate a range of nervous system patho...

    Authors: Cathra Halabi, Erika K. Williams, Ramin A. Morshed, Mauro Caffarelli, Christine Anastasiou, Tarik Tihan, Daniel Cooke, Adib A. Abla, Christopher F. Dowd, Vinil Shah, Sharon Chung and Megan B. Richie

    Citation: BMC Neurology 2021 21:205

    Content type: Case report

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  5. Since the nineteenth century, a great variety of crossed brainstem syndromes (CBS) have been described in the medical literature. A CBS typically combines ipsilateral cranial nerves deficits to contralateral l...

    Authors: Nathan Beucler, Sébastien Boissonneau, Aurélia Ruf, Stéphane Fuentes, Romain Carron and Henry Dufour

    Citation: BMC Neurology 2021 21:204

    Content type: Case report

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  6. The Low-profile Visualized Intraluminal Support (LVIS) device is a self-expanding, nitinol, single-braid, closed-cell device that was recently developed for endovascular embolization of intracranial aneurysms....

    Authors: Quanlong Hong, Wenqiang Li, Jing Ma, Peng Jiang and Yisen Zhang

    Citation: BMC Neurology 2021 21:198

    Content type: Research article

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  7. Abnormal hypoperfusion on the surgical side after carotid artery stenting is rare. Neurological deterioration caused by it is deceptive, which can easily lead to misdiagnosis. The mechanism of hypoperfusion ha...

    Authors: Zhizhong Yan, Zhonghua Shi, Yuhai Wang, Chunlei Zhang, Huize Liu, Jin Cai and Xin Zhang

    Citation: BMC Neurology 2021 21:188

    Content type: Case report

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  8. An important cause of hemisensory syndrome is ischemic stroke. However, the diagnostic yield of neuroradiological imaging on hemisensory syndrome is low. Therefore, we aim to describe patients hospitalized wit...

    Authors: Pei Xuan Koh, Joanna Ti, Seyed Ehsan Saffari, Zhen Yu Isis Claire Lim and Tianming Tu

    Citation: BMC Neurology 2021 21:179

    Content type: Research article

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  9. The physiological and pathological significance of the arachnoid membrane (AM) is still unknown. In this study, we investigated various characteristics of the AM, focusing on the influence of inflammation and ...

    Authors: Hime Suzuki, Takeshi Mikami, Naotoshi Iwahara, Yukinori Akiyama, Masahiko Wanibuchi, Katsuya Komatsu, Rintaro Yokoyama, Tsukasa Hirano, Ryusuke Hosoda, Yoshiyuki Horio, Atsushi Kuno and Nobuhiro Mikuni

    Citation: BMC Neurology 2021 21:169

    Content type: Research article

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  10. We report on a patient with an intracerebral hemorrhage (ICH), who showed delayed development of aphasia, which was demonstrated via follow up diffusion tensor tractography (DTT) to be related to neural degene...

    Authors: Min Jye Cho and Sung Ho Jang

    Citation: BMC Neurology 2021 21:166

    Content type: Case report

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  11. Patients who have been successfully treated for an aneurysmal subarachnoid hemorrhage (aSAH) often retain multiple health complaints, including mood disorders, cognitive complaints, fatigue, and problems with ...

    Authors: Edith Nobels-Janssen, Inger L. Abma, Wim I. M. Verhagen, Ronald H. M. A. Bartels, Philip J. van der Wees and Jeroen D. Boogaarts

    Citation: BMC Neurology 2021 21:162

    Content type: Research article

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  12. The initial CT blend sign is an imaging marker that has been used to predict haematoma expansion and poor outcomes in patients with small-volume intracerebral haemorrhage (ICH). However, the association of the...

    Authors: Xu Yang, Yan Zhu, Linshan Zhang, Likun Wang, Yuanhong Mao, Yinghui Li, Jinbiao Luo and Guofeng Wu

    Citation: BMC Neurology 2021 21:160

    Content type: Research article

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  13. Stroke incidence is reportedly increasing in younger populations, although the reasons for this are not clear. We explored possible reasons by quantifying trends in neurologically focused emergency department ...

    Authors: Abhinav J. Appukutty, Lesli E. Skolarus, Mellanie V. Springer, William J. Meurer and James F. Burke

    Citation: BMC Neurology 2021 21:152

    Content type: Research article

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  14. The onset time of intracerebral hemorrhage (ICH) may be closely related to the working style and living habits of people, which are determined by different income sources in China. Therefore, the purpose of ou...

    Authors: Yan-Yue Wang, Ning Yan, En-Yuan Wang and Yun-Tao Pu

    Citation: BMC Neurology 2021 21:140

    Content type: Research article

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  15. Pneumonia is related to poor prognosis in acute ischemic stroke (AIS), and its risk might be higher in atrial fibrillation (AF) related AIS with elevated plasma D-dimer. The aim of our study was to investigate...

    Authors: Xu Yang, Taoli Lu, Zhanli Qu, Yi Zhang, Pingping Liu and Ying Ma

    Citation: BMC Neurology 2021 21:137

    Content type: Research article

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  16. Stroke is a leading cause of disability worldwide and the cardiovascular fitness levels of stroke survivors are diminished to an extent that impairs functioning and activities of daily living performance. Whil...

    Authors: Hanna Reynolds, Sarah Steinfort, Jane Tillyard, Sarah Ellis, Alan Hayes, Erik D. Hanson, Tissa Wijeratne and Elizabeth H. Skinner

    Citation: BMC Neurology 2021 21:132

    Content type: Research article

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  17. The computed tomography angiography (CTA) spot sign is a validated predictor of hematoma expansion and 30-day mortality in intracerebral hemorrhage (ICH). However, whether the spot sign predicts worse function...

    Authors: Wen-Che Tseng, Yu-Fen Wang, Tyng-Guey Wang and Ming-Yen Hsiao

    Citation: BMC Neurology 2021 21:131

    Content type: Research article

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  18. Although increasing evidence showed the correlations between white matter hyperintensities (WMHs) and cognitive impairment, the relationship between them is still modest. Many researchers began to focus on the...

    Authors: Zhi-gang Min, Hai-rong Shan, Long Xu, Dai-hai Yuan, Xue-xia Sheng, Wen-chao Xie, Ming Zhang, Chen Niu, Tahir Mehmood Shakir and Zhi-hong Cao

    Citation: BMC Neurology 2021 21:128

    Content type: Research article

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  19. The effect of hypothermia on large hemispheric infarction (LHI) remains controversial. Our study aimed to explore the therapeutic outcomes of decompressive craniectomy (DC) combined with hypothermia on LHI.

    Authors: Linlin Fan, Yingying Su, Yan Zhang, Hong Ye, Weibi Chen and Gang Liu

    Citation: BMC Neurology 2021 21:114

    Content type: Research article

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  20. Global aphasia without hemiparesis (GAWH) is a rare stroke syndrome characterized by the dissociation of motor and language functions. Here, we present a case of GAWH with the patient later regaining speech fl...

    Authors: Ya-Chi Chuang, Chuan-Ching Liu, I-Ching Yu, Yu-Lin Tsai and Shin-Tsu Chang

    Citation: BMC Neurology 2021 21:111

    Content type: Case report

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  21. Although the association between periventricular target collateral anastomosis and recurrent ipsilateral hemorrhage has been evaluated in adult patients with moyamoya disease (MMD), no studies have investigate...

    Authors: Jian Wang, Qingrong Zhang, Xia Lu, Qun Liang, Yi Wang, Yichao Zhu, Shijie Na, Fang Liu, Liming Tang and Yongbo Yang

    Citation: BMC Neurology 2021 21:102

    Content type: Research article

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  22. Sex hormones may be associated with a higher incidence of ischemic stroke or stroke-related events. In observational studies, lower testosterone concentrations are associated with infirmity, vascular disease, ...

    Authors: Jung-Won Choi, In Woo Ryoo, Jun Yeong Hong, Kyung-Yul Lee, Hyo Suk Nam, Won Chan Kim, Seung-Hun Oh, Jaeku Kang, Hoi Young Lee, Sang-Jun Na, Ji Hoe Heo and Kee Ook Lee

    Citation: BMC Neurology 2021 21:91

    Content type: Research article

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  23. Neurocognitive disorder (NCD) is common in stroke survivors. We aimed to identify clinically accessible imaging markers of stroke and chronic pathology that are associated with early post-stroke NCD.

    Authors: Till Schellhorn, Eva Birgitte Aamodt, Stian Lydersen, Stina Aam, Torgeir Bruun Wyller, Ingvild Saltvedt and Mona Kristiansen Beyer

    Citation: BMC Neurology 2021 21:89

    Content type: Research article

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  24. The mu-opioid agonist methadone is administered orally and used in opioid detoxification and in the treatment of moderate-to-severe pain. Acute oral methadone–use and –abuse have been associated with inflammat...

    Authors: Jonathan Repple, Svea Haessner, Andreas Johnen, Nils C. Landmeyer, Andreas Schulte-Mecklenbeck, Marc Pawlitzki, Heinz Wiendl and Gerd Meyer zu Hörste

    Citation: BMC Neurology 2021 21:85

    Content type: Case report

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  25. In contrast to the hospital setting, today little work has been directed to the definition, measurement, and improvement of the quality of out-patient medical and therapeutic care. We developed a set of indica...

    Authors: I. Padberg, S. Heel, P. Thiem, A. Diebel, E. Mordhorst, U. Strohmeyer and A. Meisel

    Citation: BMC Neurology 2021 21:76

    Content type: Research article

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  26. Systemic cardiac hypoperfusion is a well-acknowledged contributor to ischemic leukoencephalopathy. However, it has remained elusive how atherosclerosis-mediated cardiac remodelling modifies cerebral perfusion ...

    Authors: Xiaodong Chen, Danli Lu, Ning Guo, Zhuang Kang, Ke Zhang, Jihui Wang, Xuejiao Men, Zhengqi Lu and Wei Qiu

    Citation: BMC Neurology 2021 21:67

    Content type: Research article

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  27. The neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to...

    Authors: Liang-Yu Huang, Fu-Rong Sun, Jian-Jun Yin, Ya-Hui Ma, Hong-Qi Li, Xiao-Ling Zhong, Jin-Tai Yu, Jing-Hui Song and Lan Tan

    Citation: BMC Neurology 2021 21:56

    Content type: Research article

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  28. Isolated spinal artery aneurysms are extremely rare, and their pathogenesis, clinical presentation, and treatment strategies are poorly established. We report only the second case of a patient with an isolated...

    Authors: Alexander Tenorio, Brandon B. Holmes, Adib A. Abla, Matthew Amans and Karl Meisel

    Citation: BMC Neurology 2021 21:52

    Content type: Case report

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  29. Approximately 10% of patients would develop symptomatic intracranial hemorrhage (sICH) after endovascular therapy. The aim of our study was to explore the ability of hypersensitive C-reactive protein-albumin r...

    Authors: Qiang Peng, Jiankang Hou, Siyu Wang, Feng Zhou, Yan E, Wei Wang, Ting Huang, Meng Wang, Shi Huang, Junshan Zhou, Nihong Chen and Yingdong Zhang

    Citation: BMC Neurology 2021 21:47

    Content type: Research article

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  30. Endovascular procedures with liquid embolic agents such as ethylene-vinyl alcohol (EVOH) copolymers are indicated before surgical treatment of cervical paraganglioma. Consequently, these agents are now availab...

    Authors: Santiago Moreno-Paredes, Laura Rodríguez-Alcalá, Juan Martín-Lagos Martínez, Nicolás Müller Locatelli, Cristina Vázquez López, José Luis Vargas Fernández and Álvaro Cabrera Peña

    Citation: BMC Neurology 2021 21:45

    Content type: Case report

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  31. Ambulatory and balance functions are important for maintaining general health in humans. Gait analysis allows clinicians and researchers to identify the parameters to be focused on when assessing balance and a...

    Authors: Min Cheol Chang, Byung Joo Lee, Na-Young Joo and Donghwi Park

    Citation: BMC Neurology 2021 21:38

    Content type: Research article

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  32. Hemorrhagic transformation (HT) is a serious neurological complication of acute ischemic stroke (AIS) after revascularization. The majority of AIS patients do not have atrial fibrillation (AF) which could also...

    Authors: Hao-Ran Cheng, Yun-Bin Chen, Ya-Ying Zeng, Yi-Ting Ruan, Cheng-Xiang Yuan, Qian-Qian Cheng, Hui-Jun Chen, Xiao-Qian Luan, Gui-Qian Huang and Jin-Cai He

    Citation: BMC Neurology 2021 21:36

    Content type: Research article

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  33. Internal carotid artery (ICA) stenosis has been recently reported to cause hemichorea, mainly in East Asia. The East Asian-specific p.R4810K variant of RNF213, a susceptibility gene for moyamoya disease (MMD), ac...

    Authors: Satoshi Hosoki, Takeshi Yoshimoto and Masafumi Ihara

    Citation: BMC Neurology 2021 21:32

    Content type: Case report

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  34. Hypothyroidism (HT) and carotid artery stenosis (CAS) are complications of radiotherapy (RT) in patients with head and neck cancer (HNC). The impact of post-RT HT on CAS progression remains unclear.

    Authors: Chi-Hung Liu, Joseph Tung-Chieh Chang, Tsong-Hai Lee, Pi-Yueh Chang, Chien-Hung Chang, Hsiu-Chuan Wu, Ting-Yu Chang, Kuo-Lun Huang, Chien-Yu Lin, Kang-Hsing Fan and Yeu-Jhy Chang

    Citation: BMC Neurology 2021 21:30

    Content type: Research article

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  35. This observational study was performed to show the impact of complications and interventions during neurocritical care on the outcome after aneurysmal subarachnoid hemorrhage (SAH).

    Authors: Alexander Hammer, Frank Erbguth, Matthias Hohenhaus, Christian M. Hammer, Hannes Lücking, Markus Gesslein, Monika Killer-Oberpfalzer, Hans-Herbert Steiner and Hendrik Janssen

    Citation: BMC Neurology 2021 21:27

    Content type: Research article

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  36. Stroke is a major health problem around the world. Several studies have examine the influence of ambient temperature on incidence of stoke, but they reported different results for different types of stroke and...

    Authors: Mirjam Ravljen, Fajko Bajrović and Damjan Vavpotič

    Citation: BMC Neurology 2021 21:23

    Content type: Research article

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  37. Increasing evidences have showed that neuroimaging markers of SVD can predict the short-term outcome of acute ischemic stroke (AIS). It is unclear that whether neuroimaging markers of SVD are also associated w...

    Authors: Xuemei Chen, Lin Wang, Junying Jiang, Yuanyuan Gao, Rui Zhang, Xiaoyuan Zhao, Tingwen Shen, Qi Dai and Junrong Li

    Citation: BMC Neurology 2021 21:21

    Content type: Research article

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  38. The prevalence of carotid artery stenosis (CAS) in acute ischaemic stroke (AIS) patients is historically reported at 15–20%, but an up-to-date estimate is lacking. We hypothesise it is lower than historically ...

    Authors: Twan J van Velzen, Laurien S Kuhrij, Willeke F Westendorp, Diederik van de Beek and Paul J Nederkoorn

    Citation: BMC Neurology 2021 21:20

    Content type: Research article

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  39. Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg’s syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At ...

    Authors: Jing Wang, Pei Liu, Zhongzhong Liu, Ye Tian, Guilian Zhang, Jun Guo, Li Li, Zhiqin Liu, Zucheng Han, Wenjuan Lin, Xuemei Lin, Qingli Lu, Yan Liu, Qiaoqiao Chang and Songdi Wu

    Citation: BMC Neurology 2021 21:18

    Content type: Study protocol

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