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Cerebrovascular disease and stroke

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Women have been reported to show more frequent recanalization and better recovery after intravenous (IV) recombinant tissue plasminogen activator (rt-PA) treatment for acute stroke compared with men. To invest...

    Authors: Fawaz Al-hussain, Muhammad S Hussain, Carlos Molina, Ken Uchino, Ashfaq Shuaib, Andrew M Demchuk, Andrei V Alexandrov and Maher Saqqur

    Citation: BMC Neurology 2014 14:60

    Content type: Research article

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  2. The proportion of strokes occurring in younger adults has been rising over the past decade. Due to the far longer life expectancy in the young, stroke in this group has an even larger socio-economic impact. Ho...

    Authors: Renate M Arntz, Mayte E van Alebeek, Nathalie E Synhaeve, Paul J Brouwers, Gert W van Dijk, Rob A Gons, Tom den Heijer, Paul LM de Kort, Karlijn F de Laat, Anouk G van Norden, Sarah E Vermeer, Maureen J van der Vlugt, Roy PC Kessels, Ewoud J van Dijk and Frank-Erik de Leeuw

    Citation: BMC Neurology 2014 14:55

    Content type: Study protocol

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  3. Statins, due to their well-established pleiotropic effects, have noteworthy benefits in stroke prevention. Despite this, a significant proportion of high-risk patients still do not receive the recommended ther...

    Authors: Isabella Canavero, Anna Cavallini, Patrizia Perrone, Mauro Magoni, Lucia Sacchi, Silvana Quaglini, Giordano Lanzola and Giuseppe Micieli

    Citation: BMC Neurology 2014 14:53

    Content type: Research article

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  4. Some studies reported that cerebral developmental venous anomaly (DVA) is often concurrent with cavernous malformation (CM). But there is lack of statistical evidence and study of bulk cases. The factors assoc...

    Authors: Guolu Meng, Chuanfeng Bai, Tengfei Yu, Zhen Wu, Xing Liu, Junting Zhang and Jizong zhao

    Citation: BMC Neurology 2014 14:50

    Content type: Research article

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  5. Translating knowledge derived from medical research into the clinical setting is dependent on the representativeness of included patients. Therefore we compared baseline data of patients included in a recent l...

    Authors: Christian Tanislav, Ulrike Grittner, Bjoern Misselwitz, Gerhard Jan Jungehuelsing, Christian Enzinger, Bettina von Sarnowski, Jukka Putaala, Manfred Kaps, Peter Kropp, Arndt Rolfs, Turgut Tatlisumak, Franz Fazekas, Edwin Kolodny and Bo Norrving

    Citation: BMC Neurology 2014 14:45

    Content type: Research article

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  6. Cognitive disorders, such as memory disturbances, are often observed following a subarachnoid hemorrhage. We present a very rare case where rupture of a posterior cerebral artery aneurysm caused restricted dam...

    Authors: Shinichiro Maeshima, Aiko Osawa, Fumitaka Yamane, Hidetoshi Shimaguchi, Ikuo Ochiai, Tomoyuki Yoshihara, Nahoko Uemiya, Ryuzaburo Kanazawa and Shoichiro Ishihara

    Citation: BMC Neurology 2014 14:44

    Content type: Case report

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  7. Acute ischemic stroke (AIS) has a biphasic effect on the peripheral immune system. The initial inflammatory response is followed by systemic immunosuppression, referred to as stroke-induced immunosuppression (...

    Authors: András Folyovich, Enikő Biró, Csaba Orbán, Anna Bajnok, Viktória Varga, Anna K Béres-Molnár, Barna Vásárhelyi and Gergely Toldi

    Citation: BMC Neurology 2014 14:41

    Content type: Research article

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  8. The Oxfordshire Community Stroke Project (OCSP) classification is a simple stroke classification system with value in predicting clinical outcomes. We investigated whether and how the addition of OCSP classifi...

    Authors: Sheng-Feng Sung, Solomon Chih-Cheng Chen, Huey-Juan Lin, Chih-Hung Chen, Mei-Chiun Tseng, Chi-Shun Wu, Yung-Chu Hsu, Ling-Chien Hung and Yu-Wei Chen

    Citation: BMC Neurology 2014 14:39

    Content type: Research article

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  9. Prediction of clinical outcome in the acute stage of ischaemic stroke can be difficult when based on patient characteristics, clinical findings and on non-contrast CT. CT perfusion and CT angiography may provi...

    Authors: Tom van Seeters, Geert Jan Biessels, Irene C van der Schaaf, Jan Willem Dankbaar, Alexander D Horsch, Merel JA Luitse, Joris M Niesten, Willem PTM Mali, L Jaap Kappelle, Yolanda van der Graaf and Birgitta K Velthuis

    Citation: BMC Neurology 2014 14:37

    Content type: Study protocol

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  10. Obstructive sleep apnea is a common sleep disorder in stroke patients. Obstructive sleep apnea is associated with stroke severity and poor functional outcome. Continuous positive airway pressure seems to impro...

    Authors: Justine A Aaronson, Coen AM van Bennekom, Winni F Hofman, Tijs van Bezeij, Joost G van den Aardweg, Erny Groet, Wytske A Kylstra and Ben A Schmand

    Citation: BMC Neurology 2014 14:36

    Content type: Study protocol

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  11. Meningioangiomatosis (MA) is a rare hamartomatous lesion. Only six cases of cystic MA have been reported in the literature.

    Authors: Peifeng Li, Guangbin Cui, Yingmei Wang, Ming Geng and Zhe Wang

    Citation: BMC Neurology 2014 14:32

    Content type: Case report

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  12. Cerebrovascular complications (CVCs) frequently occur in patients with acute infective endocarditis (IE). The aim of this study is to describe the clinical findings of CVCs and to evaluate the impact of CVCs o...

    Authors: Seung-Jae Lee, Sam-Sae Oh, Dal-Soo Lim, Chan-Young Na and Jae-Hyun Kim

    Citation: BMC Neurology 2014 14:30

    Content type: Research article

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  13. Spatial neglect is a frequent and debilitating consequence of acquired brain injury and currently has no widely accepted standard of care. While previous interventions for spatial neglect have targeted patient...

    Authors: Thomas Van Vleet, Joseph DeGutis, Sawsan Dabit and Christopher Chiu

    Citation: BMC Neurology 2014 14:25

    Content type: Study protocol

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  14. Subcortical hypodensities of presumed vascular etiology (SHPVO) are a clinical, radiological and neuropathological syndrome with a still largely unexplained pathophysiology. Parallel to the clinical heterogene...

    Authors: João Sargento-Freitas, Ricardo Felix-Morais, Joana Ribeiro, Ana Gouveia, César Nunes, Cristina Duque, João Madaleno, Fernando Silva, Cristina Machado, Gustavo Cordeiro and Luís Cunha

    Citation: BMC Neurology 2014 14:24

    Content type: Research article

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  15. Recurrent TIAs are thought to signal a high stroke risk. The aim of this study is to examine if repeated ischemic events increase the risk of recurrent ipsilateral stroke among patients with symptomatic 50-99%...

    Authors: Elias Johansson and Per Wester

    Citation: BMC Neurology 2014 14:23

    Content type: Research article

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  16. Perceived disability after stroke may persist long-term even among young individuals with mild stroke and may be related to age-related expectations of health and recovery. Thus, in order to appreciate the mag...

    Authors: Susanne Palmcrantz, Lotta Widén Holmqvist and Disa K Sommerfeld

    Citation: BMC Neurology 2014 14:20

    Content type: Research article

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  17. Capsular warning syndrome (CWS) is rare (1.5% of TIA presentations) but has a poor prognosis (7-day stroke risk of 60%). Up to date, the exact pathogenic mechanism of CWS has not been fully understood. We repo...

    Authors: Lixin Zhou, Jun Ni, Weihai Xu, Ming Yao, Bin Peng, Mingli Li and Liying Cui

    Citation: BMC Neurology 2014 14:16

    Content type: Case report

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  18. Infection is the most important complication after acute stroke. This is substantially based on a stroke-induced immunosuppression. Heart rate variability (HRV) represents the autonomic nervous system activity...

    Authors: Dirk Brämer, Heike Hoyer, Albrecht Günther, Samuel Nowack, Frank M Brunkhorst, Otto W Witte and Dirk Hoyer

    Citation: BMC Neurology 2014 14:9

    Content type: Study protocol

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  19. Abnormalities in nocturnal blood pressure dipping are well known for its relationship to cardiovascular diseases. Cerebral microbleeds are frequently observed in patients with hypertension and are known to be ...

    Authors: Hyung-Min Kwon, Jae-Sung Lim, Young Seo Kim, Jangsup Moon, Hyeri Park, Hyun Young Kim, Young-Hyo Lim and Hyunwoo Nam

    Citation: BMC Neurology 2014 14:8

    Content type: Research article

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  20. Cerebral infarction caused by different reasons seems differ in fibrinogen levels, so the current work intends to explore the relationship between the fibrinogen level and subtypes of the TOAST criteria in the...

    Authors: Qi Lang, Muke Zhou, Hong Feng, Jian Guo, Ning Chen and Li He

    Citation: BMC Neurology 2013 13:207

    Content type: Research article

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  21. The detection of early neuropsychological abnormalities as precursors of cognitive decline of vascular origin in patients with lacunar stroke is a subject of increasing interest. The objective of this study wa...

    Authors: Lorena Blanco-Rojas, Adrià Arboix, David Canovas, Marta Grau-Olivares, Joan Carles Oliva Morera and Olga Parra

    Citation: BMC Neurology 2013 13:203

    Content type: Research article

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  22. Stroke campaigns are educating about the need to immediately contact the emergency medical system if symptoms occur. Despite higher stroke rates among patients with diabetics and some migrant populations, ther...

    Authors: Birgitta M Weltermann, Youcef Driouach-Bleckmann, Sabrina Reinders, Peter Berndt and Stefan Gesenhues

    Citation: BMC Neurology 2013 13:202

    Content type: Research article

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  23. In up to 30% of patients with ischemic stroke no definite etiology can be established. A significant proportion of cryptogenic stroke cases may be due to non-stenosing atherosclerotic plaques or low grade carotid...

    Authors: Anna Bayer-Karpinska, Florian Schwarz, Frank A Wollenweber, Holger Poppert, Tobias Boeckh-Behrens, Alexander Becker, Dirk A Clevert, Konstantin Nikolaou, Christian Opherk, Martin Dichgans and Tobias Saam

    Citation: BMC Neurology 2013 13:201

    Content type: Study protocol

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  24. Evidence indicates that the continuation of therapy among community-dwelling stroke survivors improves physical function. Community rehabilitation programmes often face limitations in terms of resources. It is...

    Authors: Devinder Kaur Ajit Singh, Nor Azlin Mohd Nordin, Noor Azah Abd Aziz, Beng Kooi Lim and Li Ching Soh

    Citation: BMC Neurology 2013 13:199

    Content type: Research article

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  25. Physical activity is believed to exert a beneficial effect on functional and cognitive rehabilitation of patients with stroke. Although studies have addressed the impact of physical exercise in cerebrovascular...

    Authors: Alexander H Nave, Jan M Kröber, Peter Brunecker, Jochen B Fiebach, Jonathan List, Ulrike Grittner, Matthias Endres, Andreas Meisel, Agnes Flöel and Martin Ebinger

    Citation: BMC Neurology 2013 13:197

    Content type: Study protocol

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  26. The Hajj Ceremony, the largest annual gathering in the world, is the most important life event for any Muslim. This study was designed to evaluate the incidence of stroke among Iranian pilgrims during the Hajj...

    Authors: Mahmoud Reza Azarpazhooh, Reza Bavarsad Shahripour, Moira K Kapral, Naghmeh Mokhber, Ali Shoeibi, Mohammad Taghi Farzadfard, Mohammad Reza Rafati, Amanda G Thrift, Negar Morovatdar, Seyed Aidin Sajedi and Amir Azarpazhooh

    Citation: BMC Neurology 2013 13:193

    Content type: Research article

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  27. Acid–base imbalance in various metabolic disturbances leads to human brain dysfunction. Compared with acidosis, the patients suffered from alkalosis demonstrate more severe neurological signs that are difficul...

    Authors: Shuyan Zhang, Piyun Sun, Zhongren Sun, Jingyu Zhang, Jinlong Zhou and Yingli Gu

    Citation: BMC Neurology 2013 13:192

    Content type: Research article

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  28. A wealth of published studies have been published on association between Chlamydia pneumoniae (C.pneumoniae) infection and cerebrovascular (CV) disease, but the results were inconsistent. This meta-analysis pr...

    Authors: Juan Chen, Meijia Zhu, Gaoting Ma, Zhangning Zhao and Zhongwen Sun

    Citation: BMC Neurology 2013 13:183

    Content type: Research article

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  29. Recently, plasma miRNAs have been reported as biomarkers for various diseases. However, the knowledge on the association of plasma miRNAs with ischemic stroke is still lacking. In this study, we investigated w...

    Authors: Guangwen Long, Feng Wang, Huaping Li, Zhongwei Yin, Chaugai Sandip, Yan Lou, Yan Wang, Chen Chen and Dao Wen Wang

    Citation: BMC Neurology 2013 13:178

    Content type: Research article

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  30. Subarachnoid hemorrhage (SAH) is a devastating cause of stroke, occurring in relatively young people. It has been suggested that some immune-mediated diseases may be associated with an increased risk of SAH.

    Authors: Sreeram V Ramagopalan, Julia Pakpoor, Olena Seminog, Raph Goldacre, Lee Graham and Michael J Goldacre

    Citation: BMC Neurology 2013 13:176

    Content type: Research article

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  31. Vertebral artery origin (VAO) stenosis is occasionally observed in patients who have acute ischemic stroke. We investigated the long-term outcomes and clinical significance of VAO stenosis in patients with acu...

    Authors: Young Jin Kim, Joon Hwa Lee, Jin Woo Choi, Hong Gee Roh, Young Il Chun, Ji-Sung Lee and Hahn Young Kim

    Citation: BMC Neurology 2013 13:171

    Content type: Research article

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  32. Cerebral vasculopathy have been described in Fabry disease, in which altered cerebral blood flow, vascular remodelling or impairment of endothelial function could be involved. Our study aims to evaluate these ...

    Authors: Tomás Segura, Oscar Ayo-Martín, Isabel Gómez-Fernandez, Carolina Andrés, Miguel A Barba and José Vivancos

    Citation: BMC Neurology 2013 13:170

    Content type: Research article

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  33. Prospective observation of hemodynamic changes before and after formation of brain aneurysms is often difficult. We used a vessel surface repair method to carry out a retrospective hemodynamic study before and...

    Authors: Wei-Jie Le, Yue-Qi Zhu, Ming-Hua Li, Lei Yan, Hua-Qiao Tan, Shi-Min Xiao and Ying-Sheng Cheng

    Citation: BMC Neurology 2013 13:166

    Content type: Research article

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  34. In-stent restenosis (ISR) is an important factor endangering the long-term safety and efficacy of carotid artery angioplasty and stenting (CAS). It is plausible that soft vulnerable plaques are more likely to ...

    Authors: Katrin Wasser, André Karch, Sonja Gröschel, Janin Witzenhausen, Klaus Gröschel, Mathias Bähr and Jan Liman

    Citation: BMC Neurology 2013 13:163

    Content type: Research article

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  35. Bone marrow-derived endothelial stem cells participate in vascular repairs. Numbers of circulating endothelial progenitor cells (cEPCs) are associated with atherosclerosis. Fibrinogen plays a key role in ather...

    Authors: Zhizhong Liu, Xiurong Ding, Fang Fang, Ruimin Wang, Yan Chen, Yuetao Ma, Guojun Zhang and Xixiong Kang

    Citation: BMC Neurology 2013 13:161

    Content type: Research article

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  36. The Stroke burden is increasing in many populations where health institutions may experience more patients. We wanted to examine whether incidence rates and absolute number of hospitalized stroke patients rema...

    Authors: Malene Nøhr Demant, Charlotte Andersson, Ole Ahlehoff, Mette Charlot, Jonas Bjerring Olesen, Anne Gjesing, Peter R Hansen, Gunnar H Gislason, Thomas Truelsen and Christian Torp-Pedersen

    Citation: BMC Neurology 2013 13:156

    Content type: Research article

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  37. Cardio embolism and cerebrovascular atherosclerosis are two major mechanisms of stroke. Studies investigating associations between advanced echocardiographic parameters and stroke mechanisms are limited.

    Authors: Quratulain Shaikh, Bilal Ahmed, Maryam Ahmed, Jamal Hussain Mahar, Masood Ahmad, Ayesha Ahmed, Farzin Majeed, Fariha Sadiq Ali, Maria Khan and Ayeesha Kamran Kamal

    Citation: BMC Neurology 2013 13:149

    Content type: Research article

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  38. Stroke is the second most common cause of death and disability worldwide. It is a multi-factorial disease influenced by both environmental and genetic factors. Studies from the different ethnic regions of worl...

    Authors: Amit Kumar, Ram Sagar, Pradeep Kumar, Jitendra K Sahu, Ashoo Grover, Achal K Srivastava, S Vivekanandhan and Kameshwar Prasad

    Citation: BMC Neurology 2013 13:136

    Content type: Study protocol

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  39. The clinical profiles of cerebellar cavernous malformations (CCMs) with and without associated developmental venous anomalies (DVAs) are not well known. The aims of this study were to analyze the clinical and ...

    Authors: Peifeng Zhang, Lingtong Liu, Yong Cao, Shuo Wang and Jizong Zhao

    Citation: BMC Neurology 2013 13:134

    Content type: Research article

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  40. Stroke is the 4th leading cause of death and 1st leading cause of disability in Singapore. However the information on long-term post stroke outcomes for Singaporean patients was limited. This study aimed to in...

    Authors: Yan Sun, Sze Haur Lee, Bee Hoon Heng and Vivien S Chin

    Citation: BMC Neurology 2013 13:133

    Content type: Research article

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  41. Silent brain infarcts are detected by neuroimaging in up to 20% of asymptomatic patients based on population studies. They are five times more frequent than stroke in general population, and increase significa...

    Authors: Iolanda Riba-Llena, Carmen Ioana Jarca, Xavier Mundet, Jose L Tovar, Francesc Orfila, Antonio López-Rueda, Cristina Nafría, Jose L Fernández, Xavier Castañé, Mar Domingo, José Álvarez-Sabín, Inés Fernández-Cortiñas, Olga Maisterra, Joan Montaner and Pilar Delgado

    Citation: BMC Neurology 2013 13:130

    Content type: Study protocol

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  42. Despite heart failure being a substantial risk factor for stroke, few studies have evaluated the predictive value of heart dysfunction for all-cause mortality in patients with acute ischemic stroke, in particu...

    Authors: Alexandra Holmström, Michael LX Fu, Clara Hjalmarsson, Lena Bokemark and Björn Andersson

    Citation: BMC Neurology 2013 13:122

    Content type: Research article

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