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Cerebrovascular disease and stroke

Section edited by Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. DL-3-n-butylphthalide (NBP) was demonstrated to increase the cerebral blood flow (CBF) in the animal models, but there are no clinic studies to verify this. We aimed to explore the effect of NBP on improving c...

    Authors: Dawei Chen, Yanwei Yin, Jin Shi, Fen Yang, Kehua Wang, Faguo Zhao, Wenping Li and Bin Li

    Citation: BMC Neurology 2020 20:212

    Content type: Research article

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  2. Vestibular migraine, a kind of acute vestibular syndrome, leads to both migraines and vertigo symptoms in a single patient. The occurrence of vestibular migraine has shown an obvious increase in female groups ...

    Authors: Ying Xin, Junyi Fu, Longchang Xie, Jie Yang and Guanhao Ke

    Citation: BMC Neurology 2020 20:211

    Content type: Case report

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  3. Stroke burden in young adults is growing associated with unique risk factors and devastating outcomes. We aimed to investigate the magnitude, risk factors and outcomes of first ever stroke in young adults ≤45 ...

    Authors: Sarah Shali Matuja, Patricia Munseri and Khuzeima Khanbhai

    Citation: BMC Neurology 2020 20:206

    Content type: Research article

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  4. Direct evidence of intimal flaps, double lumen and intramural haematomas (IMH) is difficult to detect on conventional angiography in most intracranial vertebrobasilar dissecting aneurysms (VBDAs). Our purpose ...

    Authors: Xianjin Zhu, Hancheng Qiu, Ferdinand K. Hui, Yiqun Zhang, Yun-e Liu, Fengyuan Man and Wei-Jian Jiang

    Citation: BMC Neurology 2020 20:199

    Content type: Research article

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  5. Acute ischemic stroke attack with and without a recent TIA may differ in clinical risk factors, and this may affect treatment outcomes following thrombolytic therapy. We examined whether the odds of exclusion ...

    Authors: Nicolas Poupore, Dan Strat, Tristan Mackey, Ashley Snell and Thomas Nathaniel

    Citation: BMC Neurology 2020 20:197

    Content type: Research article

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  6. Endovascular therapy (EVT) is increasingly used to improve cerebral reperfusion after moderate-to-severe acute ischemic stroke (AIS). However, the influence of hemodynamic factors on clinical outcome is still ...

    Authors: Ge Tian, Zhong Ji, Kaibin Huang, Zhenzhou Lin, Suyue Pan and Yongming Wu

    Citation: BMC Neurology 2020 20:189

    Content type: Research article

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  7. Recovery patterns of motor function and activity capacity of the upper extremity after stroke have been described, but less is known about longitudinal changes of perceived manual activity performance. The aim...

    Authors: Elisabeth Ekstrand, Katharina S. Sunnerhagen, Hanna C. Persson, Åsa Lundgren-Nilsson and Margit Alt Murphy

    Citation: BMC Neurology 2020 20:181

    Content type: Research article

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  8. The etiologic determinants of cryptogenic stroke remain a diagnostic challenge in clinical practice. Fabry disease (FD) is one of the monogenic causes of stroke that may remain unrecognized as a potential cont...

    Authors: Shuai Jiang, Lei Wang, Yuying Yan, Qiange Zhu, Jincheng Wan, Jiayu Sun and Bo Wu

    Citation: BMC Neurology 2020 20:180

    Content type: Case report

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  9. Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI is unclear. We hypothesize that amyloid deposition, measu...

    Authors: Guri Hagberg, Hege Ihle-Hansen, Brynjar Fure, Bente Thommessen, Håkon Ihle-Hansen, Anne Rita Øksengård, Mona K. Beyer, Torgeir B. Wyller, Ebba Gløersen Müller, Sarah T. Pendlebury and Per Selnes

    Citation: BMC Neurology 2020 20:174

    Content type: Research article

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  10. Insufficient amounts of physical activity is a risk factor for (recurrent) stroke. People with a stroke or transient ischemic attack (TIA) have a high risk of recurrent stroke and have lower levels of physical...

    Authors: Wendy Hendrickx, Lara Vlietstra, Karin Valkenet, Roderick Wondergem, Cindy Veenhof, Coralie English and Martijn Frits Pisters

    Citation: BMC Neurology 2020 20:168

    Content type: Research article

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  11. Stroke-like episodes (SLEs) in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) with m.3243A > G mutation usually develop in the cerebral cortex. Few reports have docum...

    Authors: Munenori Oyama, Takahiro Iizuka, Jin Nakahara and Yoshikane Izawa

    Citation: BMC Neurology 2020 20:167

    Content type: Case report

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  12. Early neurological deterioration (END) is common in acute ischemic stroke (IS). However, the underlying mechanisms for END are unclear. The aim of this study was to evaluate the associations of 16 variants in ...

    Authors: Xingyang Yi, Qiang Zhou, Yongyin Zhang, Ju Zhou and Jing Lin

    Citation: BMC Neurology 2020 20:159

    Content type: Research article

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  13. Dysphagia is common after stroke. Patients with dysphagia have a higher risk of stroke-associated pneumonia (SAP) and poor outcomes. Early detection of dysphagia is necessary to identify and manage patients at...

    Authors: Zhu-Yun Liu, Xiao-Pei Zhang, Miao-Miao Mo, Ri-Chun Ye, Cai-Xia Hu, Min-Qing Jiang and Man-Qiu Lin

    Citation: BMC Neurology 2020 20:154

    Content type: Research article

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  14. Cerebrovascular disease (CVD) survivors are at a high risk of recurrent stroke. Although it is thought that survivors with higher risk of stroke respond better to stroke onset, to date, no study has been able ...

    Authors: Shengde Li, Li-Ying Cui, Craig Anderson, Chunpeng Gao, Chengdong Yu, Guangliang Shan, Longde Wang and Bin Peng

    Citation: BMC Neurology 2020 20:147

    Content type: Research article

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  15. Endovascular therapy is widely used in acute large vessel occlusion. This study investigated whether imaging of lateral lenticulostriate arteries (LSAs) before thrombectomy would potentially be helpful for pre...

    Authors: Feifeng Liu, Chen Chen, Lan Hong, Hao Shen, Wenjie Cao, Qiang Dong, Xinyi Yang, Mengruo Guo, Ying Li, Yaping Xiao, Xin Cheng and Gang Li

    Citation: BMC Neurology 2020 20:139

    Content type: Research article

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  16. Following acute ischemic stroke (AIS), approximately half of patients do not achieve recanalization after intravenous administration of tissue plasminogen activator (rt-PA). Thrombolysis resistance is a possib...

    Authors: Ye Li, Heying Wang, Lili Zhao, Yating Jian, Meijuan Dang, Yu Jiang, Yiheng Zhang, Lei Zhang, Huqing Wang, Ru Zhang, Mingxia Chen and Guilian Zhang

    Citation: BMC Neurology 2020 20:135

    Content type: Case report

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  17. For acute ischemic stroke (AIS) patient receiving mechanical thrombectomy (MT), renal dysfunction was an independent risk factor of contrast-induced nephropathy which may affect clinical outcomes. However, the...

    Authors: Xiding Pan, Feng Zhou, Rui Shen, Yubing Zhu, Hisatomi Arima, Jie Yang and Junshan Zhou

    Citation: BMC Neurology 2020 20:134

    Content type: Research article

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  18. Cavernous malformations are rare cerebral pseudo-vascular lesions with annualized bleeding rates of 0.5–3% in most studies. Of the various explored risk factors for bleeding to date, only prior hemorrhage has ...

    Authors: Benjamin R. Hartley, Corinne Birnbaum and Caitlin E. Hoffman

    Citation: BMC Neurology 2020 20:131

    Content type: Case report

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  19. Hyperhomocysteinemia (HHCY) is a risk factor for cardiovascular and cerebrovascular diseases. The C677T 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism increases homocysteine (HCY) levels. ...

    Authors: Xiaoxia Du, Lin Xiao, Rong Sun, Kunpeng Li, Lin Liang, Luping Song and Zhizhong Liu

    Citation: BMC Neurology 2020 20:128

    Content type: Research article

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  20. The modified Rankin Scale (mRS) is a key global outcome measure after stroke internationally. The latest English version of the simplified modified Rankin scale questionnaire (smRSq)(2011) is a reliable and va...

    Authors: Junliang Yuan, Yunxiao Wang, Wenli Hu and Askiel Bruno

    Citation: BMC Neurology 2020 20:127

    Content type: Research article

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  21. Associations between serum phosphorus level and the incidence of ischemic stroke are not clear. This study aimed to measure serum phosphorus, vitamin D3, and uric acid levels in ischemic stroke patients compar...

    Authors: Abolfazl Talebi, Alireza Amirabadizadeh, Samaneh Nakhaee, Zahra Ahmadi and Seyed Mohammad Mousavi-Mirzaei

    Citation: BMC Neurology 2020 20:116

    Content type: Research article

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  22. French Guiana has the highest incidence of ischemic and hemorrhagic stroke of all French territories. However, there is no further information on the epidemiology and management of stroke in French Guiana. Our...

    Authors: Dévi Rita Rochemont, Emmanuelle Mimeau, Caroline Misslin-Tritsch, Martine Papaix-Puech, Emmanuel Delmas, Yannick Bejot, Bertrand DeToffol, Isabelle Fournel and Mathieu Nacher

    Citation: BMC Neurology 2020 20:109

    Content type: Research article

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  23. Bilateral medial medullary infarction (MMI) is uncommon and bilateral medial pons infarction (MPI) is even rarer. “Heart appearance” on magnetic resonance imaging (MRI) is a characteristic presentation of bila...

    Authors: Zhi-Hua Zhou, Yun-Fan Wu, Wei-Feng Wu, Ai-Qun Liu, Qing-Yun Yu, Zhong-Xing Peng and Ming-Fan Hong

    Citation: BMC Neurology 2020 20:107

    Content type: Case report

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  24. Psoriasis is the most common chronic inflammatory condition involving the T helper cell system. Population studies have demonstrated that patients with psoriasis and/or psoriatic arthritis have an increased ri...

    Authors: Joline M. Fan, David A. Solomon, Giselle Y. López, Jeffrey W. Hofmann, Rene A. Colorado, Anthony S. Kim, Karl Meisel and Cathra Halabi

    Citation: BMC Neurology 2020 20:106

    Content type: Case report

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  25. Telemedicine improves the quality of acute stroke care in rural regions with limited access to specialized stroke care. We report the first 2 years’ experience of implementing a comprehensive telemedical strok...

    Authors: Katharina M. A. Gabriel, Steffi Jírů-Hillmann, Peter Kraft, Udo Selig, Viktoria Rücker, Johannes Mühler, Klaus Dötter, Matthias Keidel, Hassan Soda, Alexandra Rascher, Rolf Schneider, Mathias Pfau, Roy Hoffmann, Joachim Stenzel, Mohamed Benghebrid, Tobias Goebel…

    Citation: BMC Neurology 2020 20:104

    Content type: Research article

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  26. Ruptured intracranial aneurysms are often associated with subarachnoid or intraparenchymal hemorrhage. However, the prevalence of subdural hemorrhage post aneurysmal rupture is low and rarely reported in scien...

    Authors: Abdulrahman Hamad Al-Abdulwahhab, Abdulaziz Mohammad Al-Sharydah, Sari Saleh Al-Suhibani, Abdullah Salman Almulhim, Obaied M. Al-Dhafeeri and Saeed A. Al-Jubran

    Citation: BMC Neurology 2020 20:102

    Content type: Case report

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  27. Sleep fragmentation was shown to be positively associated with cognitive impairment in patients with cerebral small vessel disease (CSVD); however, the underlying mechanisms are not well characterized. In this...

    Authors: Jihui Wang, Xiaodong Chen, Jinchi Liao, Li Zhou, Hongying Han, Jiong Tao and Zhengqi Lu

    Citation: BMC Neurology 2020 20:98

    Content type: Research article

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  28. In adults, the anastomosis between carotid and vertebrobasilar arteries is usually the posterior communicating artery, sometimes the primitive trigeminal artery. In this case, the basilar artery fed the intern...

    Authors: Xiaogang Liu, Bing Li, Ying Liu, Hongliang Wu, Huilong Zhang, Lianwei Dou and Chuanyu Liu

    Citation: BMC Neurology 2020 20:97

    Content type: Case report

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  29. Infectious basilar artery (BA) aneurysm has been occasionally reported to be generated from meningitis following transcranial operation. However, infectious BA aneurysm formed by intracranial infection after e...

    Authors: Xu Wang, Ge Chen, Mingchu Li, Jiantao Liang, Hongchuan Guo, Gang Song and Yuhai Bao

    Citation: BMC Neurology 2020 20:94

    Content type: Case report

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  30. To investigate predictors of postoperative acute intracranial hemorrhage (AIH) and recurrence of chronic subdural hematoma (CSDH) after burr hole drainage.

    Authors: Fu Mei Chen, Ke Wang, Kang Li Xu, Li Wang, Tian Xiang Zhan, Fei Cheng, Hao Wang, Zuo-Bing Chen, Liang Gao and Xiao Feng Yang

    Citation: BMC Neurology 2020 20:92

    Content type: Research article

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  31. Even though clearly defined pathways for vocational re-entry are well recognized for conditions such as mental health, musculoskeletal dysfunction (MSD) and traumatic brain injury (TBI), none has been identifi...

    Authors: Olumide Ayoola Olaoye, Shaheed Moghammad Soeker and Anthea Rhoda

    Citation: BMC Neurology 2020 20:91

    Content type: Research article

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  32. Despite the utility of neuroimaging in the diagnostic and therapeutic management of patients with acute ischemic stroke (AIS), imaging characteristics in patients with preceding direct oral anticoagulants (DOA...

    Authors: Thomas Raphael Meinel, Johannes Kaesmacher, Jan Gralla, David J. Seiffge, Elias Auer, Sebastién Frey, Marwan El-Koussy, Marcel Arnold, Urs Fischer, Martina Göldlin, Simon Jung and Arsany Hakim

    Citation: BMC Neurology 2020 20:86

    Content type: Research article

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  33. Randomized controlled trials (RCTs) demonstrated efficacy and safety of endovascular treatment (ET) in anterior circulation large vessel occlusions (LVO). We aimed at investigating how stroke patients treated ...

    Authors: Milani Deb-Chatterji, Hans Pinnschmidt, Fabian Flottmann, Hannes Leischner, Anna Alegiani, Caspar Brekenfeld, Jens Fiehler, Christian Gerloff and Götz Thomalla

    Citation: BMC Neurology 2020 20:81

    Content type: Research article

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  34. The most characteristic clinical signs of stroke are motor and/or sensory involvement of one side of the body. Respiratory involvement has also been described, which could be related to diaphragmatic dysfuncti...

    Authors: José Vicente Catalá-Ripoll, José Ángel Monsalve-Naharro and Francisco Hernández-Fernández

    Citation: BMC Neurology 2020 20:79

    Content type: Research article

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  35. In aneurysmal subarachnoid hemorrhage (SAH) and multiple intracranial aneurysms (MIAs) identification of the bleeding source cannot always be assessed according to the hemorrhage pattern. Therefore, we develop...

    Authors: Alexis Hadjiathanasiou, Patrick Schuss, Simon Brandecker, Thomas Welchowski, Matthias Schmid, Hartmut Vatter and Erdem Güresir

    Citation: BMC Neurology 2020 20:70

    Content type: Research article

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  36. Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, the role of Treg in human acute IS has been poorly investigated....

    Authors: María Santamaría-Cadavid, Emilio Rodríguez-Castro, Manuel Rodríguez-Yáñez, Susana Arias-Rivas, Iria López-Dequidt, María Pérez-Mato, Manuel Rodríguez-Pérez, Ignacio López-Loureiro, Pablo Hervella, Francisco Campos, José Castillo, Ramón Iglesias-Rey and Tomás Sobrino

    Citation: BMC Neurology 2020 20:68

    Content type: Research article

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  37. Inflammation plays an important role in atherosclerosis but the contribution of neutrophils to this process is unclear. We sought to assess whether neutrophil count is associated with intracranial atherosclero...

    Authors: Xing Zhang, Xiao-He Hou, Ya-Hui Ma, Xue-Ning Shen, Xi-Peng Cao, Jing-Hui Song, Lan Tan and Jin-Tai Yu

    Citation: BMC Neurology 2020 20:65

    Content type: Research article

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  38. Fenestration of vertebra-basilar artery is an uncommon congenital vascular anomaly, which is identified by incidental findings on imaging in patients presented without related symptoms or in patients with intr...

    Authors: Feng Wang, Xiaokai Wang, Xiaohua Li, Huifeng Zheng and Zhiyong Zhang

    Citation: BMC Neurology 2020 20:63

    Content type: Case report

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  39. Current guidelines limit thrombolytic treatment of stroke to those patients who present within 4.5 h to minimize the risk of hemorrhagic complications. Risk of hemorrhage increases with increasing blood-brain ...

    Authors: Jarrhett Butler, Parisa Heidari, Sarah Blayney, Emi Hitomi, Marie Luby and Richard Leigh

    Citation: BMC Neurology 2020 20:54

    Content type: Research article

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  40. It is unclear whether non-high-density lipoprotein cholesterol (Non-HDL-C) is associated with haemorrhagic transformation (HT) after acute ischaemic stroke (AIS). We aimed to explore the association between No...

    Authors: Yanan Wang, Quhong Song, Yajun Cheng, Chenchen Wei, Chen Ye, Junfeng Liu, Bo Wu and Ming Liu

    Citation: BMC Neurology 2020 20:47

    Content type: Research article

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  41. Chulalongkorn Stroke Center is a comprehensive stroke center (CSC) located in Bangkok, Thailand. Our stroke network consists of different levels of spoke hospitals, ranging from community hospitals where throm...

    Authors: Naruchorn Kijpaisalratana, Aurauma Chutinet, Wasan Akarathanawat, Pakkawan Vongvasinkul and Nijasri C. Suwanwela

    Citation: BMC Neurology 2020 20:45

    Content type: Research article

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  42. Due to uniform stiffness of standard platinum coils, dense packing of intracranial aneurysms can be difficult to achieve, since stiffer coils can cause microcatheter prolapse or coil migration. SMART coils hav...

    Authors: Behme Daniel, Sack Henrik, Tsogkas Ioannis, Rohde Veit and Psychogios Marios-Nikos

    Citation: BMC Neurology 2020 20:38

    Content type: Research article

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    The Correction to this article has been published in BMC Neurology 2020 20:188

  43. We report on a stroke patient with disorder of consciousness (DOC) who underwent repetitive transcranial magnetic stimulation (rTMS) and showed recovery of an injured upper ascending reticular activating syste...

    Authors: Sung Ho Jang and Young Hyeon Kwon

    Citation: BMC Neurology 2020 20:37

    Content type: Case report

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