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Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Content type: Study protocol

    The level of physical activity undertaken by stroke survivors living in the community is generally low. The main objectives of the IMPACT trial are to determine, in individuals undergoing rehabilitation after str...

    Authors: Sandra G. Brauer, Suzanne S. Kuys, Jennifer D. Paratz and Louise Ada

    Citation: BMC Neurology 2018 18:13

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  2. Content type: Research article

    Data on the association between socioeconomic status and post-stroke functional outcome in developing countries is lacking. We aimed to evaluate the association in stroke survivors in deprived rural Southern C...

    Authors: Fubing Ouyang, Ying Wang, Weixian Huang, Yicong Chen, Yuhui Zhao, Ge Dang, Chunbo Zhang, Yang Lin and Jinsheng Zeng

    Citation: BMC Neurology 2018 18:12

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  3. Content type: Review

    Following the success of recent endovascular trials, endovascular therapy has emerged as an exciting addition to the arsenal of clinical management of patients with acute ischemic stroke (AIS). In this paper, ...

    Authors: Sonu Bhaskar, Peter Stanwell, Dennis Cordato, John Attia and Christopher Levi

    Citation: BMC Neurology 2018 18:8

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  4. Content type: Study protocol

    Cervicocephalic artery dissection (CAD) is an important etiology of stroke in the youth. Findings from recent studies suggest it a “group of disease entities” with different underlying etiologies, presentation...

    Authors: Zhu Zhu, Yuyuan Xu, Yilong Wang, Zhenhua Zhou, Xiang Han, Aihua Liu, Jing Peng, Yi Xu and Luyao Wang

    Citation: BMC Neurology 2018 18:6

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  5. Content type: Research article

    Repetitive sensory stimulation (RSS) adapts the timing of stimulation protocols used in cellular studies to induce synaptic plasticity. In healthy subjects, RSS leads to widespread sensorimotor cortical reorga...

    Authors: Jan C. Kattenstroth, Tobias Kalisch, Matthias Sczesny-Kaiser, Wolfgang Greulich, Martin Tegenthoff and Hubert R. Dinse

    Citation: BMC Neurology 2018 18:2

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  6. Content type: Research article

    Cortical vein thrombosis (CVT) receives little attention in adult patients with cerebral venous sinus thrombosis (CVST). This study aimed to investigate the clinical and radiological features of adult CVST pat...

    Authors: Jiahui Liang, Hongbing Chen, Zhuhao Li, Shaofu He, Boning Luo, Shujin Tang, Wenjin Shang and Jinsheng Zeng

    Citation: BMC Neurology 2017 17:219

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  7. Content type: Research article

    Growing evidence indicates that elevated body temperature after stroke is associated with unfavorable outcome. The aim of the current study was to investigate which factors predict temperature elevation within...

    Authors: Rebecca Ruborg, Karin Gunnarsson and Jakob O. Ström

    Citation: BMC Neurology 2017 17:218

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  8. Content type: Case report

    Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome, is the most common phenotype of mitochondrial disease. It often develops in childhood or adolescence, usually ...

    Authors: Satomi Mezuki, Kenji Fukuda, Tomonaga Matsushita, Yoshihisa Fukushima, Ryu Matsuo, Yu-ichi Goto, Takehiro Yasukawa, Takeshi Uchiumi, Dongchon Kang, Takanari Kitazono and Tetsuro Ago

    Citation: BMC Neurology 2017 17:217

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  9. Content type: Case report

    Secondary pallidonigral transneuronal degeneration after a remote primary cerebral infarct can mimic recurrent stroke at clinical presentation. We describe a patient with secondary pallidonigral degeneration f...

    Authors: Ruei-Je Tsai, Li-Chun Hsieh, Sho-Jen Cheng and Cheng-Yu Chen

    Citation: BMC Neurology 2017 17:215

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  10. Content type: Research article

    Thalamic hemorrhages cause motor paralysis, sensory impairment, and cognitive dysfunctions, all of which may significantly affect walking independence. We examined the factors related to independent walking in...

    Authors: Shigenori Hiraoka, Shinichiro Maeshima, Hideto Okazaki, Hirokazu Hori, Shinichiro Tanaka, Sayaka Okamoto, Reisuke Funahashi, Kei Yagihashi, Ikuko Fuse, Naoki Asano and Shigeru Sonoda

    Citation: BMC Neurology 2017 17:211

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  11. Content type: Research article

    Atrial fibrillation (AF) is reported to be a less frequent cause of ischemic stroke in China than in Europe and North America, but it is not clear whether this is due to underestimation. Our aim was to define ...

    Authors: Xiaomeng Yang, Shuya Li, Xingquan Zhao, Liping Liu, Yong Jiang, Zixiao Li, Yilong Wang and Yongjun Wang

    Citation: BMC Neurology 2017 17:207

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  12. Content type: Research article

    Clinical trials are the hallmark of evidence-based medicine, but recruitment is often challenging, especially in stroke trials investigating patients not being able to give informed consent. In some nations, e...

    Authors: Benjamin Hotter, Lena Ulm, Sarah Hoffmann, Mira Katan, Joan Montaner, Alejandro Bustamante and Andreas Meisel

    Citation: BMC Neurology 2017 17:206

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  13. Content type: Research article

    Evaluation of secondary stroke prevention in low and middle-income countries remains limited. This study assessed the prescription of secondary preventive drugs among ischemic stroke patients upon hospital dis...

    Authors: Wen Yea Hwong, Zariah Abdul Aziz, Norsima Nazifah Sidek, Michiel L. Bots, Sharmini Selvarajah, L. Jaap Kappelle, Sheamini Sivasampu and Ilonca Vaartjes

    Citation: BMC Neurology 2017 17:203

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  14. Content type: Research article

    Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality of life. However, the pathogenesis of PSD is still not clear. This study aimed to investigate the demographic, cl...

    Authors: Guilin Meng, Xiaoye Ma, Lei Li, Yan Tan, Xiaohui Liu, Xueyuan Liu and Yanxin Zhao

    Citation: BMC Neurology 2017 17:199

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  15. Content type: Research article

    The neuroprotective effects of neuroserpin (NSP) have been well documented in both patients and animal models with cerebral ischemia; however, have never been investigated in hemorrhagic stroke. The aim of thi...

    Authors: Wei Li, Tetsuya Asakawa, Sha Han, Baoguo Xiao, Hiroki Namba, Chuanzhen Lu, Qiang Dong and Liang Wang

    Citation: BMC Neurology 2017 17:196

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  16. Content type: Case report

    Supernumerary phantom limb (SPL) is a rare neurologic phenomenon, in which a patient misperceives an extra limb in addition to the original set of limbs. We report a case of SPL in a patient with a right basal...

    Authors: Hang-Rai Kim, Jee-young Han, Young Ho Park, Beom Joon Kim, Wookjin Yang and SangYun Kim

    Citation: BMC Neurology 2017 17:180

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  17. Content type: Study protocol

    Stroke is a leading cause of death and disability, and despite intensive research, few treatment options exist. However, a recent breakthrough in cell therapy is expected to reverse the neurological sequelae o...

    Authors: Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, Tuyoshi Teramoto, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Shunsuke Terasaka, Teruyo Arato and Kiyohiro Houkin

    Citation: BMC Neurology 2017 17:179

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  18. Content type: Research article

    We aimed to develop a tool, the hemorrhagic transformation (HT) index (HTI), to predict any HT within 14 days after middle cerebral artery (MCA) stroke onset regardless of the intravenous recombinant tissue pl...

    Authors: Mikhail N. Kalinin, Dina R. Khasanova and Murat M. Ibatullin

    Citation: BMC Neurology 2017 17:177

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  19. Content type: Research article

    While neurogranin has no value as plasma biomarker for Alzheimer’s disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin l...

    Authors: Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs and Eugeen Vanmechelen

    Citation: BMC Neurology 2017 17:170

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  20. Content type: Research article

    Whether there are differences in pathogenesis among different types and subtypes of cerebral watershed infarction (WSI) is controversial since they have been combined into a single group in most previous studies.

    Authors: Yue Li, Man Li, Xiaoyu Zhang, Shuna Yang, Huimin Fan, Wei Qin, Lei Yang, Junliang Yuan and Wenli Hu

    Citation: BMC Neurology 2017 17:166

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  21. Content type: Research article

    In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.

    Authors: Seong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin and Ji Man Hong

    Citation: BMC Neurology 2017 17:169

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  22. Content type: Case report

    Non-traumatic, spontaneous subarachnoid hemorrhage occurs in approximately 85% of cases where there is a ruptured saccular aneurysm. An additional 10% of cases arise from non-aneurysmal peri-mesencephalic hemo...

    Authors: Anna Misyail Abdul Rashid and Mohamad Syafeeq Faeez Md Noh

    Citation: BMC Neurology 2017 17:165

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  23. Content type: Research article

    Standard echocardiography (SE) is an essential part of the routine diagnostic work-up after ischemic stroke (IS) and also serves for research purposes. However, access to SE is often limited. We aimed to asses...

    Authors: Peter Kraft, Anna Fleischer, Silke Wiedmann, Viktoria Rücker, Daniel Mackenrodt, Caroline Morbach, Uwe Malzahn, Christoph Kleinschnitz, Stefan Störk and Peter U. Heuschmann

    Citation: BMC Neurology 2017 17:159

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  24. Content type: Research article

    Previous studies have identified various treatment and patient characteristics that may be associated with higher hospital cost after spontaneous intracerebral hemorrhage (ICH); a devastating type of stroke. P...

    Authors: Adrian V. Specogna, Tanvir C. Turin, Scott B. Patten and Michael D. Hill

    Citation: BMC Neurology 2017 17:158

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  25. Content type: Research article

    Enlarged perivascular spaces (EPVS) are often observed with magnetic resonance imaging in patients with small vessel disease. However, the risk factors, radiological features, and clinical relevance of EPVS in...

    Authors: Tomoyoshi Kuribara, Takeshi Mikami, Katsuya Komatsu, Hime Suzuki, Hirofumi Ohnishi, Kiyohiro Houkin and Nobuhiro Mikuni

    Citation: BMC Neurology 2017 17:149

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  26. Content type: Research article

    The present study aimed to investigate the prevalence and risk factors for extracranial carotid artery stenosis (ECAS) and intracranial carotid artery stenosis (ICAS) simultaneously in asymptomatic Chinese pur...

    Authors: Haiqiang Jin, Qing Peng, Ding Nan, Pu Lv, Ran Liu, Wei Sun, Yuming Teng, Yuanyuan Liu, Chenghe Fan, Haiying Xing, Ke Xu and Yining Huang

    Citation: BMC Neurology 2017 17:136

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  27. Content type: Study protocol

    Patients discharged home after stroke face significant challenges managing residual neurological deficits, secondary prevention, and pre-existing chronic conditions. Post-discharge care is often fragmented lea...

    Authors: Pamela W. Duncan, Cheryl D. Bushnell, Wayne D. Rosamond, Sara B. Jones Berkeley, Sabina B. Gesell, Ralph B. D’Agostino Jr, Walter T. Ambrosius, Blair Barton-Percival, Janet Prvu Bettger, Sylvia W. Coleman, Doyle M. Cummings, Janet K. Freburger, Jacqueline Halladay, Anna M. Johnson, Anna M. Kucharska-Newton, Gladys Lundy-Lamm…

    Citation: BMC Neurology 2017 17:133

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  28. Content type: Research article

    Basilar artery branch atheromatous disease (BABAD), in which basilar artery atheroma occludes penetrating arteries at their origin, is a common etiology of posterior circulation stroke (PCS). It is currently u...

    Authors: Po-Chen Lin, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Yung-Yang Lin and Chih-Ping Chung

    Citation: BMC Neurology 2017 17:135

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  29. Content type: Research article

    The aim of this study was to investigate the predictors of intensive care unit (ICU) admission and mortality among stroke patients and the effects of a pulmonary rehabilitation program on stroke patients.

    Authors: Belma Doğan Güngen, Abdulkadir Tunç, Yeşim Güzey Aras, Aslı Aksoy Gündoğdu, Adil Can Güngen and Serdar Bal

    Citation: BMC Neurology 2017 17:132

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  30. Content type: Research article

    Delivery of therapeutic agents as erythropoietin (EPO) into Central Nervous System through intranasal route could benefit patients with neurological disorders. A new nasal formulation containing a non-hematopo...

    Authors: Orestes Santos-Morales, Alina Díaz-Machado, Daise Jiménez-Rodríguez, Yaisel Pomares-Iturralde, Tatiana Festary-Casanovas, Carlos A. González-Delgado, Sonia Pérez-Rodríguez, Eulalia Alfonso-Muñoz, Carmen Viada-González, Patricia Piedra-Sierra, Idrian García-García, Daniel Amaro-González, Julio César García-Rodríguez, Iliana Sosa-Testé, Alicia Lagarto-Parra, Laura Barrero-Viera…

    Citation: BMC Neurology 2017 17:129

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  31. Content type: Case report

    Vitamin K inhibitors (e.g. warfarin) and indirect thrombin inhibitors (e.g. heparin) are widely used to prevent thromboembolic disorders (e.g. myocardial infarction, venous thromboembolism, and stroke). These ...

    Authors: Hyun Goo Kang, Seung Jae Lee, Ji Yeon Chung and Jin Sung Cheong

    Citation: BMC Neurology 2017 17:124

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  32. Content type: Research article

    Accumulating evidence has shown that cigarette smoking is an important risk factor for ischemic stroke. However, it is not clear about the potential mechanisms through which cigarette smoking affects stroke ri...

    Authors: Ruijun Ji, Yuesong Pan, Hongyi Yan, Runhua Zhang, Gaifen Liu, Penglian Wang, Yilong Wang, Hao Li, Xingquan Zhao and Yongjun Wang

    Citation: BMC Neurology 2017 17:120

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  33. Content type: Database

    Although International Classification of Disease, Ninth Revision, Clinical Modification (ICD9-CM) coding is the basis of administrative claims data, no study has validated an ICD9-CM algorithm to identify patient...

    Authors: Hormuzdiyar H. Dasenbrock, David J. Cote, Yuri Pompeu, Viren S. Vasudeva, Timothy R. Smith and William B. Gormley

    Citation: BMC Neurology 2017 17:121

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  34. Content type: Study protocol

    For some stroke patients and caregivers, navigating the transition between hospital discharge and returning home is associated with substantial psychosocial and health-related challenges. Currently, no evidenc...

    Authors: Mathew J. Reeves, Anne K. Hughes, Amanda T. Woodward, Paul P. Freddolino, Constantinos K. Coursaris, Sarah J. Swierenga, Lee H. Schwamm and Michele C. Fritz

    Citation: BMC Neurology 2017 17:115

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  35. Content type: Research article

    It is a common belief in medical community that lunar phases have an impact on human health. A growing body of evidence indicates that lunar phases can predict the risk to develop acute neurological and vascul...

    Authors: Adomas Bunevicius, Agne Gendvilaite, Vytenis Pranas Deltuva and Arimantas Tamasauskas

    Citation: BMC Neurology 2017 17:99

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  36. Content type: Study protocol

    Aggressively lowering blood pressure (BP) in acute intracerebral hemorrhage (ICH) may improve outcome. Although there is no evidence that BP reduction changes cerebral blood flow, retrospective magnetic resona...

    Authors: Laura Gioia, Ana Klahr, Mahesh Kate, Brian Buck, Dariush Dowlatshahi, Thomas Jeerakathil, Derek Emery and Kenneth Butcher

    Citation: BMC Neurology 2017 17:100

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  37. Content type: Research article

    Diabetes mellitus (DM) is a risk factor for early neurological deterioration (END) in acute ischemic stroke. The prothrombotic protein fibrinogen is frequently elevated in patients with diabetes, and may be as...

    Authors: Seong-Joon Lee, Ji Man Hong, Sung Eun Lee, Dae Ryong Kang, Bruce Ovbiagele, Andrew M. Demchuk and Jin Soo Lee

    Citation: BMC Neurology 2017 17:101

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  38. Content type: Research article

    There are contradictory reports concerning the validity of transcranial sonography (TCD and TCCS) for examinations of the basilar artery. Here we investigated sensitivity and specificity of transcranial sonogr...

    Authors: Woori Koh, Kai Kallenberg, André Karch, Tobias Frank, Michael Knauth, Mathias Bähr and Jan Liman

    Citation: BMC Neurology 2017 17:89

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  39. Content type: Case report

    Detailed knowledge of every possible manifestation of Internal Carotid Artery (ICA) disease is important. For improving detection and a timely adoption of secondary prevention procedures or treatments. Transie...

    Authors: José Carlos Morán-Sánchez, Irene Gómez-Estévez, Yasmina El Berdei, José C. Gómez-Sánchez and María E. Ramos-Araque

    Citation: BMC Neurology 2017 17:69

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  40. Content type: Research article

    Post-stroke delirium is a common problem in the care of stroke patients, and is associated with longer hospitalization, high short-term mortality, and an increased need for long-term care. Although post-stroke...

    Authors: Tae Sung Lim, Jin Soo Lee, Jung Han Yoon, So Young Moon, In Soo Joo, Kyoon Huh and Ji Man Hong

    Citation: BMC Neurology 2017 17:56

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  41. Content type: Research article

    Factors influencing access to stroke unit (SU) care and data on quality of SU care in Germany are scarce. We investigated characteristics of patients directly admitted to a SU as well as patient-related and st...

    Authors: Steffi Hillmann, Silke Wiedmann, Viktoria Rücker, Klaus Berger, Darius Nabavi, Ingo Bruder, Hans-Christian Koennecke, Günter Seidel, Björn Misselwitz, Alfred Janssen, Christoph Burmeister, Christine Matthis, Otto Busse, Peter Hermanek and Peter Ulrich Heuschmann

    Citation: BMC Neurology 2017 17:49

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  42. Content type: Research article

    Although the Brain Attack Coalition recommended establishing centers of comprehensive care for stroke and cerebrovascular disease patients, a scoring system for such centers was lacking. We created and validat...

    Authors: Akiko Kada, Kunihiro Nishimura, Jyoji Nakagawara, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Kazunori Toyoda, Shinya Matsuda, Akifumi Suzuki, Hiroharu Kataoka, Fumiaki Nakamura, Satoru Kamitani and Koji Iihara

    Citation: BMC Neurology 2017 17:46

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  43. Content type: Case report

    Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through in...

    Authors: Kai Shan and Wei Guo

    Citation: BMC Neurology 2017 17:33

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  44. Content type: Study protocol

    Recurrent strokes are preventable through awareness and control of risk factors such as hypertension, and through lifestyle changes such as healthier diets, greater physical activity, and smoking cessation. Ho...

    Authors: Amytis Towfighi, Eric M. Cheng, Monica Ayala-Rivera, Heather McCreath, Nerses Sanossian, Tara Dutta, Bijal Mehta, Robert Bryg, Neal Rao, Shlee Song, Ali Razmara, Magaly Ramirez, Theresa Sivers-Teixeira, Jamie Tran, Elizabeth Mojarro-Huang, Ana Montoya…

    Citation: BMC Neurology 2017 17:24

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