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Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Content type: Case report

    Supernumerary phantom limb (SPL) is a rare neurologic phenomenon, in which a patient misperceives an extra limb in addition to the original set of limbs. We report a case of SPL in a patient with a right basal...

    Authors: Hang-Rai Kim, Jee-young Han, Young Ho Park, Beom Joon Kim, Wookjin Yang and SangYun Kim

    Citation: BMC Neurology 2017 17:180

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  2. Content type: Study protocol

    Stroke is a leading cause of death and disability, and despite intensive research, few treatment options exist. However, a recent breakthrough in cell therapy is expected to reverse the neurological sequelae o...

    Authors: Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, Tuyoshi Teramoto, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Shunsuke Terasaka, Teruyo Arato and Kiyohiro Houkin

    Citation: BMC Neurology 2017 17:179

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  3. Content type: Research article

    We aimed to develop a tool, the hemorrhagic transformation (HT) index (HTI), to predict any HT within 14 days after middle cerebral artery (MCA) stroke onset regardless of the intravenous recombinant tissue pl...

    Authors: Mikhail N. Kalinin, Dina R. Khasanova and Murat M. Ibatullin

    Citation: BMC Neurology 2017 17:177

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  4. Content type: Research article

    While neurogranin has no value as plasma biomarker for Alzheimer’s disease, it may be a potential blood biomarker for traumatic brain injury. This evokes the question whether there are changes in neurogranin l...

    Authors: Ann De Vos, Maria Bjerke, Raf Brouns, Naomi De Roeck, Dirk Jacobs, Lien Van den Abbeele, Kaat Guldolf, Henrik Zetterberg, Kaj Blennow, Sebastiaan Engelborghs and Eugeen Vanmechelen

    Citation: BMC Neurology 2017 17:170

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  5. Content type: Research article

    Whether there are differences in pathogenesis among different types and subtypes of cerebral watershed infarction (WSI) is controversial since they have been combined into a single group in most previous studies.

    Authors: Yue Li, Man Li, Xiaoyu Zhang, Shuna Yang, Huimin Fan, Wei Qin, Lei Yang, Junliang Yuan and Wenli Hu

    Citation: BMC Neurology 2017 17:166

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  6. Content type: Research article

    In order to evaluate the impact of cilostazol on endothelial function, we compared the changes of flow-mediated dilation (FMD) between aspirin and cilostazol groups in patients with acute cerebral ischemia.

    Authors: Seong-Joon Lee, Jin Soo Lee, Mun Hee Choi, Sung Eun Lee, Dong Hoon Shin and Ji Man Hong

    Citation: BMC Neurology 2017 17:169

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  7. Content type: Case report

    Non-traumatic, spontaneous subarachnoid hemorrhage occurs in approximately 85% of cases where there is a ruptured saccular aneurysm. An additional 10% of cases arise from non-aneurysmal peri-mesencephalic hemo...

    Authors: Anna Misyail Abdul Rashid and Mohamad Syafeeq Faeez Md Noh

    Citation: BMC Neurology 2017 17:165

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  8. Content type: Research article

    Standard echocardiography (SE) is an essential part of the routine diagnostic work-up after ischemic stroke (IS) and also serves for research purposes. However, access to SE is often limited. We aimed to asses...

    Authors: Peter Kraft, Anna Fleischer, Silke Wiedmann, Viktoria Rücker, Daniel Mackenrodt, Caroline Morbach, Uwe Malzahn, Christoph Kleinschnitz, Stefan Störk and Peter U. Heuschmann

    Citation: BMC Neurology 2017 17:159

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  9. Content type: Research article

    Previous studies have identified various treatment and patient characteristics that may be associated with higher hospital cost after spontaneous intracerebral hemorrhage (ICH); a devastating type of stroke. P...

    Authors: Adrian V. Specogna, Tanvir C. Turin, Scott B. Patten and Michael D. Hill

    Citation: BMC Neurology 2017 17:158

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  10. Content type: Research article

    Enlarged perivascular spaces (EPVS) are often observed with magnetic resonance imaging in patients with small vessel disease. However, the risk factors, radiological features, and clinical relevance of EPVS in...

    Authors: Tomoyoshi Kuribara, Takeshi Mikami, Katsuya Komatsu, Hime Suzuki, Hirofumi Ohnishi, Kiyohiro Houkin and Nobuhiro Mikuni

    Citation: BMC Neurology 2017 17:149

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  11. Content type: Research article

    The present study aimed to investigate the prevalence and risk factors for extracranial carotid artery stenosis (ECAS) and intracranial carotid artery stenosis (ICAS) simultaneously in asymptomatic Chinese pur...

    Authors: Haiqiang Jin, Qing Peng, Ding Nan, Pu Lv, Ran Liu, Wei Sun, Yuming Teng, Yuanyuan Liu, Chenghe Fan, Haiying Xing, Ke Xu and Yining Huang

    Citation: BMC Neurology 2017 17:136

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  12. Content type: Study protocol

    Patients discharged home after stroke face significant challenges managing residual neurological deficits, secondary prevention, and pre-existing chronic conditions. Post-discharge care is often fragmented lea...

    Authors: Pamela W. Duncan, Cheryl D. Bushnell, Wayne D. Rosamond, Sara B. Jones Berkeley, Sabina B. Gesell, Ralph B. D’Agostino Jr, Walter T. Ambrosius, Blair Barton-Percival, Janet Prvu Bettger, Sylvia W. Coleman, Doyle M. Cummings, Janet K. Freburger, Jacqueline Halladay, Anna M. Johnson, Anna M. Kucharska-Newton, Gladys Lundy-Lamm…

    Citation: BMC Neurology 2017 17:133

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  13. Content type: Research article

    Basilar artery branch atheromatous disease (BABAD), in which basilar artery atheroma occludes penetrating arteries at their origin, is a common etiology of posterior circulation stroke (PCS). It is currently u...

    Authors: Po-Chen Lin, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Yung-Yang Lin and Chih-Ping Chung

    Citation: BMC Neurology 2017 17:135

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  14. Content type: Research article

    The aim of this study was to investigate the predictors of intensive care unit (ICU) admission and mortality among stroke patients and the effects of a pulmonary rehabilitation program on stroke patients.

    Authors: Belma Doğan Güngen, Abdulkadir Tunç, Yeşim Güzey Aras, Aslı Aksoy Gündoğdu, Adil Can Güngen and Serdar Bal

    Citation: BMC Neurology 2017 17:132

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  15. Content type: Research article

    Delivery of therapeutic agents as erythropoietin (EPO) into Central Nervous System through intranasal route could benefit patients with neurological disorders. A new nasal formulation containing a non-hematopo...

    Authors: Orestes Santos-Morales, Alina Díaz-Machado, Daise Jiménez-Rodríguez, Yaisel Pomares-Iturralde, Tatiana Festary-Casanovas, Carlos A. González-Delgado, Sonia Pérez-Rodríguez, Eulalia Alfonso-Muñoz, Carmen Viada-González, Patricia Piedra-Sierra, Idrian García-García, Daniel Amaro-González, Julio César García-Rodríguez, Iliana Sosa-Testé, Alicia Lagarto-Parra, Laura Barrero-Viera…

    Citation: BMC Neurology 2017 17:129

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  16. Content type: Case report

    Vitamin K inhibitors (e.g. warfarin) and indirect thrombin inhibitors (e.g. heparin) are widely used to prevent thromboembolic disorders (e.g. myocardial infarction, venous thromboembolism, and stroke). These ...

    Authors: Hyun Goo Kang, Seung Jae Lee, Ji Yeon Chung and Jin Sung Cheong

    Citation: BMC Neurology 2017 17:124

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  17. Content type: Research article

    Accumulating evidence has shown that cigarette smoking is an important risk factor for ischemic stroke. However, it is not clear about the potential mechanisms through which cigarette smoking affects stroke ri...

    Authors: Ruijun Ji, Yuesong Pan, Hongyi Yan, Runhua Zhang, Gaifen Liu, Penglian Wang, Yilong Wang, Hao Li, Xingquan Zhao and Yongjun Wang

    Citation: BMC Neurology 2017 17:120

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  18. Content type: Database

    Although International Classification of Disease, Ninth Revision, Clinical Modification (ICD9-CM) coding is the basis of administrative claims data, no study has validated an ICD9-CM algorithm to identify patient...

    Authors: Hormuzdiyar H. Dasenbrock, David J. Cote, Yuri Pompeu, Viren S. Vasudeva, Timothy R. Smith and William B. Gormley

    Citation: BMC Neurology 2017 17:121

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  19. Content type: Study protocol

    For some stroke patients and caregivers, navigating the transition between hospital discharge and returning home is associated with substantial psychosocial and health-related challenges. Currently, no evidenc...

    Authors: Mathew J. Reeves, Anne K. Hughes, Amanda T. Woodward, Paul P. Freddolino, Constantinos K. Coursaris, Sarah J. Swierenga, Lee H. Schwamm and Michele C. Fritz

    Citation: BMC Neurology 2017 17:115

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  20. Content type: Research article

    It is a common belief in medical community that lunar phases have an impact on human health. A growing body of evidence indicates that lunar phases can predict the risk to develop acute neurological and vascul...

    Authors: Adomas Bunevicius, Agne Gendvilaite, Vytenis Pranas Deltuva and Arimantas Tamasauskas

    Citation: BMC Neurology 2017 17:99

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  21. Content type: Study protocol

    Aggressively lowering blood pressure (BP) in acute intracerebral hemorrhage (ICH) may improve outcome. Although there is no evidence that BP reduction changes cerebral blood flow, retrospective magnetic resona...

    Authors: Laura Gioia, Ana Klahr, Mahesh Kate, Brian Buck, Dariush Dowlatshahi, Thomas Jeerakathil, Derek Emery and Kenneth Butcher

    Citation: BMC Neurology 2017 17:100

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  22. Content type: Research article

    Diabetes mellitus (DM) is a risk factor for early neurological deterioration (END) in acute ischemic stroke. The prothrombotic protein fibrinogen is frequently elevated in patients with diabetes, and may be as...

    Authors: Seong-Joon Lee, Ji Man Hong, Sung Eun Lee, Dae Ryong Kang, Bruce Ovbiagele, Andrew M. Demchuk and Jin Soo Lee

    Citation: BMC Neurology 2017 17:101

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  23. Content type: Research article

    There are contradictory reports concerning the validity of transcranial sonography (TCD and TCCS) for examinations of the basilar artery. Here we investigated sensitivity and specificity of transcranial sonogr...

    Authors: Woori Koh, Kai Kallenberg, André Karch, Tobias Frank, Michael Knauth, Mathias Bähr and Jan Liman

    Citation: BMC Neurology 2017 17:89

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  24. Content type: Case report

    Detailed knowledge of every possible manifestation of Internal Carotid Artery (ICA) disease is important. For improving detection and a timely adoption of secondary prevention procedures or treatments. Transie...

    Authors: José Carlos Morán-Sánchez, Irene Gómez-Estévez, Yasmina El Berdei, José C. Gómez-Sánchez and María E. Ramos-Araque

    Citation: BMC Neurology 2017 17:69

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  25. Content type: Research article

    Post-stroke delirium is a common problem in the care of stroke patients, and is associated with longer hospitalization, high short-term mortality, and an increased need for long-term care. Although post-stroke...

    Authors: Tae Sung Lim, Jin Soo Lee, Jung Han Yoon, So Young Moon, In Soo Joo, Kyoon Huh and Ji Man Hong

    Citation: BMC Neurology 2017 17:56

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  26. Content type: Research article

    Factors influencing access to stroke unit (SU) care and data on quality of SU care in Germany are scarce. We investigated characteristics of patients directly admitted to a SU as well as patient-related and st...

    Authors: Steffi Hillmann, Silke Wiedmann, Viktoria Rücker, Klaus Berger, Darius Nabavi, Ingo Bruder, Hans-Christian Koennecke, Günter Seidel, Björn Misselwitz, Alfred Janssen, Christoph Burmeister, Christine Matthis, Otto Busse, Peter Hermanek and Peter Ulrich Heuschmann

    Citation: BMC Neurology 2017 17:49

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  27. Content type: Research article

    Although the Brain Attack Coalition recommended establishing centers of comprehensive care for stroke and cerebrovascular disease patients, a scoring system for such centers was lacking. We created and validat...

    Authors: Akiko Kada, Kunihiro Nishimura, Jyoji Nakagawara, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Kazunori Toyoda, Shinya Matsuda, Akifumi Suzuki, Hiroharu Kataoka, Fumiaki Nakamura, Satoru Kamitani and Koji Iihara

    Citation: BMC Neurology 2017 17:46

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  28. Content type: Case report

    Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through in...

    Authors: Kai Shan and Wei Guo

    Citation: BMC Neurology 2017 17:33

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  29. Content type: Study protocol

    Recurrent strokes are preventable through awareness and control of risk factors such as hypertension, and through lifestyle changes such as healthier diets, greater physical activity, and smoking cessation. Ho...

    Authors: Amytis Towfighi, Eric M. Cheng, Monica Ayala-Rivera, Heather McCreath, Nerses Sanossian, Tara Dutta, Bijal Mehta, Robert Bryg, Neal Rao, Shlee Song, Ali Razmara, Magaly Ramirez, Theresa Sivers-Teixeira, Jamie Tran, Elizabeth Mojarro-Huang, Ana Montoya…

    Citation: BMC Neurology 2017 17:24

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  30. Content type: Research article

    Conflicting results on the correlation between hyperuricemia and the prognosis of stroke had been reported and the close association between serum uric acid (SUA) and abnormal glycomatabolism might further com...

    Authors: Shuolin Wu, Yuesong Pan, Ning Zhang, Wang Yong Jun and Chunxue Wang

    Citation: BMC Neurology 2017 17:21

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  31. Content type: Research article

    Increased level of blood viscosity, which is one of the major factors that determine blood rheology, has been reported as a risk factor or predictor for cerebrovascular events. We investigated how blood viscos...

    Authors: Seung Hoon Song, Jeong Hee Kim, Joon Hwa Lee, Yeo-Min Yun, Dong-Hee Choi and Hahn Young Kim

    Citation: BMC Neurology 2017 17:20

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  32. Content type: Research article

    Understanding the gap between evidence-based recommendations and real-world management is important to inform priority setting and health service planning.

    Authors: Giovanni Corrao, Federico Rea, Luca Merlino, Paolo Mazzola, Federico Annoni and Giorgio Annoni

    Citation: BMC Neurology 2017 17:12

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  33. Content type: Research article

    We conducted a prospective cohort study to investigate prevalence of poststroke cognitive impairment at 3 and 12 months after stroke onset and identify clinical and demographic factors associated with improvem...

    Authors: Jin A. Yoon, Deog Young Kim, Min Kyun Sohn, Jongmin Lee, Sam-Gyu Lee, Yang-Soo Lee, Eun Young Han, Min Cheol Joo, Gyung-Jae Oh, Junhee Han, Minsu Park, Kyung Pil Park, Kyung-Ha Noh, Won Hyuk Chang, Yong-Il Shin and Yun-Hee Kim

    Citation: BMC Neurology 2017 17:9

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  34. Content type: Research article

    The underlying pathophysiology of BA distribution is unclear and intriguing. Using high-resolution magnetic resonance imaging (HR-MRI), we sought to explore the plaque distribution of low-grade basilar artery ...

    Authors: Jin Yu, Ming-Li Li, Yu-Yuan Xu, Shi-Wen Wu, Min Lou, Xue-Tao Mu, Feng Feng, Shan Gao and Wei-Hai Xu

    Citation: BMC Neurology 2017 17:8

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  35. Content type: Research article

    There is a link between high on-treatment platelet reactivity (HPR) and adverse vascular events in stroke. This study aimed to compare multiple electrode platelet aggregometry (MEA), in healthy subjects and is...

    Authors: Ahmed Sabra, Sophia N. Stanford, Sharon Storton, Matthew Lawrence, Lindsay D’Silva, Roger H. K. Morris, Vanessa Evans, Mushtaq Wani, John F. Potter and Phillip A. Evans

    Citation: BMC Neurology 2016 16:254

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  36. Content type: Research article

    There is very little information about the quality of life (QOL) of stroke survivors in LMIC countries with underdeveloped non communicable health infrastructures, who bear two thirds of the global stroke burden.

    Authors: Wardah Khalid, Shafquat Rozi, Tazeen Saeed Ali, Iqbal Azam, Michael T. Mullen, Saleem Illyas, Qamar un-Nisa, Nabila Soomro and Ayeesha Kamran Kamal

    Citation: BMC Neurology 2016 16:250

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  37. Content type: Research article

    The health-related quality of life in stroke patients (HRQOLISP-40, short version) survey was developed in Nigeria and constitutes a 40-item, multidimensional, self-administrated questionnaire. We assessed the...

    Authors: Yahira Rossini Guzmán Sabogal, Jorge Pla Vidal, Ricardo Sánchez Pedraza, Felipe Ortuño Sánchez-Pedreño and María Catalina Gómez Guevara

    Citation: BMC Neurology 2016 16:246

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  38. Content type: Research article

    Patients with acute stroke often do not seek immediate medical help, which is assumed to be driven by lack of knowledge of stroke symptoms. We explored the process of help seeking behavior in patients with acu...

    Authors: E. Zock, H. Kerkhoff, R. P. Kleyweg, T. B. V. van Bavel-Ta, S. Scott, N. D. Kruyt, P. J. Nederkoorn and D. van de Beek

    Citation: BMC Neurology 2016 16:241

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  39. Content type: Research article

    High body temperatures after ischemic stroke have been associated with larger infarct size, but the temporal profile of this relation is unknown. We assess the relation between temporal profile of body tempera...

    Authors: Marjolein Geurts, Féline E. V. Scheijmans, Tom van Seeters, Geert J. Biessels, L. Jaap Kappelle, Birgitta K. Velthuis and H. Bart van der Worp

    Citation: BMC Neurology 2016 16:233

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  40. Content type: Case report

    Few previous hemodynamic studies demonstrated the detailed features of rupture point of intracranial aneurysms. The hemodynamic simulation for the case that ruptured during angiography was even rare. In the pr...

    Authors: Yisen Zhang, Linkai Jing, Ying Zhang, Jian Liu and Xinjian Yang

    Citation: BMC Neurology 2016 16:231

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  41. Content type: Case report

    It is clinically rare to find cytomegalovirus (CMV)-associated encephalomyelitis in immunocompetent adults. Here, we present the case of an adult patient who developed acute transverse myelitis that was follow...

    Authors: Kensuke Daida, Yuta Ishiguro, Hiroto Eguchi, Yutaka Machida, Nobutaka Hattori and Hideto Miwa

    Citation: BMC Neurology 2016 16:223

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  42. Content type: Research article

    While the precise timing and intensity of very early rehabilitation (VER) after stroke onset is still under discussion, its beneficial effect on functional disability is generally accepted. The recently publis...

    Authors: Björn Reuter, Christoph Gumbinger, Tamara Sauer, Horst Wiethölter, Ingo Bruder, Curt Diehm, Peter A. Ringleb, Werner Hacke, Michael G. Hennerici and Rolf Kern

    Citation: BMC Neurology 2016 16:222

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  43. Content type: Research article

    A description of the complexity of the process of self-management and the way stroke survivors give meaning to their process of self-management post-stroke is lacking. This study explores how stroke survivors ...

    Authors: Ton Satink, Staffan Josephsson, Jana Zajec, Edith H. C. Cup, Bert J. M. de Swart and Maria W. G. Nijhuis-van der Sanden

    Citation: BMC Neurology 2016 16:221

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  44. Content type: Research article

    Virtual reality (VR) training is thought to improve upper limb (UL) motor function after stroke when utilizing intensive training with many repetitions. The purpose of this study was to compare intensity and c...

    Authors: Iris Brunner, Jan Sture Skouen, Håkon Hofstad, Jörg Aßmuss, Frank Becker, Hanne Pallesen, Liselot Thijs and Geert Verheyden

    Citation: BMC Neurology 2016 16:219

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  45. Content type: Research article

    Despite that disability of the upper extremity is common after stroke, there is limited knowledge how it influences self-perceived ability to perform daily hand activities. The aim of this study was to describ...

    Authors: Elisabeth Ekstrand, Lars Rylander, Jan Lexell and Christina Brogårdh

    Citation: BMC Neurology 2016 16:208

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