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Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Content type: Research article

    Cerebral microvascular abnormality is frequently associated with lacunar and subcortical ischemic lesions. We performed acute and follow-up CT perfusion scans over the first 3 months after ischemic stroke to i...

    Authors: Jun Yang, Christopher d’Esterre, Stefano Ceruti, Gloria Roversi, Andrea Saletti, Enrico Fainardi and Ting Yim Lee

    Citation: BMC Neurology 2015 15:214

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  2. Content type: Study protocol

    An effective diagnostic work-up in hospitalized patients with acute ischemic stroke is vital to optimize secondary stroke prevention. The HEart and BRain interfaces in Acute ischemic Stroke (HEBRAS) study aims to...

    Authors: Karl Georg Haeusler, Ulrike Grittner, Jochen B. Fiebach, Matthias Endres, Thomas Krause and Christian H. Nolte

    Citation: BMC Neurology 2015 15:213

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  3. Content type: Study protocol

    Several systematic reviews have shown that additional exercise therapy has a positive effect on functional outcome after stroke. However, there is an urgent need for resource-efficient methods to augment rehab...

    Authors: Judith Vloothuis, Marijn Mulder, Rinske H M Nijland, Manin Konijnenbelt, Henry Mulder, Cees M P M Hertogh, Maurits van Tulder, Gert Kwakkel and Erwin van Wegen

    Citation: BMC Neurology 2015 15:193

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  4. Content type: Research article

    Pure dysarthria (PD) and dysarthria-facial paresis syndrome (DFP) mainly result from lenticulostriate artery territory infarction. PD and DFP are rare clinical entities, often grouped without distinction. The ...

    Authors: Koji Tanaka, Takeshi Yamada, Takako Torii, Takeo Yoshimura, Kei-ichiro Takase, Osamu Togao, Yoshifumi Wakata, Akio Hiwatashi, Naoki Nakashima, Jun-ichi Kira and Hiroyuki Murai

    Citation: BMC Neurology 2015 15:184

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  5. Content type: Research article

    Fatigue is a common complaint after stroke. Reasons for higher prevalence are still unclear. This study aimed to determine if fatigue prevalence in stroke patients is different to that of age and gender matche...

    Authors: Thorlene Egerton, Anne Hokstad, Torunn Askim, Julie Bernhardt and Bent Indredavik

    Citation: BMC Neurology 2015 15:181

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  6. Content type: Research article

    Assessing the level of public stroke awareness is a prerequisite for development of community educational campaigns aimed at reducing prehospital delay of stroke patients. The Stroke Action Test (STAT) is a va...

    Authors: Licia Denti, Barbara Marcomini, Silvia Riva, Peter J. Schulz and Caterina Caminiti

    Citation: BMC Neurology 2015 15:76

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  7. Content type: Research article

    Data estimating the recurrence and risk of death are lacking in low and middle income countries, where two thirds of the stroke burden occurs. Previously we had shown that the incidence and mortality have been...

    Authors: Norberto Luiz Cabral, Milena Muller, Selma Cristina Franco, Alexandre Longo, Carla Moro, Vivian Nagel, Rafaela B Liberato, Adriana C Garcia, Vanessa G Venancio and Anderson RR Gonçalves

    Citation: BMC Neurology 2015 15:70

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  8. Content type: Research article

    Large intracranial occlusive vascular disease is a major contributor to the incidence of stroke worldwide, especially when it involves the middle cerebral artery (MCA). The data on the prognosis of symptomatic...

    Authors: Lili Tian, Xuanye Yue, Gangming Xi, Youmeng Wang, Zongyou Li, Ying Zhou and Xiaobing Fan

    Citation: BMC Neurology 2015 15:68

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  9. Content type: Research article

    The relationship between central obesity and stroke is inconsistent in diabetic and non-diabetic populations. This indicates an interaction between diabetes and central obesity on stroke risk. The present stud...

    Authors: Jennifer Olofindayo, Hao Peng, Yan Liu, Hongmei Li, Mingzhi Zhang, Aili Wang and Yonghong Zhang

    Citation: BMC Neurology 2015 15:65

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  10. Content type: Case report

    The treatment option for acute ischaemic stroke depends on the duration of symptoms, the dynamics of neurological condition changes, the aetiology, type of stroke, as well as the results of angiographic and ne...

    Authors: Anetta Lasek-Bal, Tomasz Urbanek, Damian Ziaja, Aldona Warsz-Wianecka, Przemysław Puz and Krzysztof Ziaja

    Citation: BMC Neurology 2015 15:62

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  11. Content type: Study protocol

    A visual field defect (VFD) is a common consequence of stroke with a detrimental effect upon the survivors’ functional ability and quality of life. The identification of effective treatments for VFD is a key p...

    Authors: Tobias Loetscher, Celia Chen, Sophie Wignall, Andreas Bulling, Sabrina Hoppe, Owen Churches, Nicole A Thomas, Michael E R Nicholls and Andrew Lee

    Citation: BMC Neurology 2015 15:64

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  12. Content type: Research article

    Both apathy and suicide are common in poststroke patients. However, the association between poststroke apathy and suicide-related ideation (SI) in Chinese stroke patients is not clear and poorly understood. Th...

    Authors: Wai Kwong Tang, Lara Caeiro, Chieh Grace Lau, Huajun Liang, Vincent Mok, Gabor S Ungvari and Ka Sing Wong

    Citation: BMC Neurology 2015 15:60

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  13. Content type: Research article

    In the context of an epidemiologic transition in South Africa, in which cardiovascular disease is increasing, little is known about the stroke burden, particularly morbidity in rural populations. Risk factors ...

    Authors: Mandy Maredza, Melanie Y Bertram and Stephen M Tollman

    Citation: BMC Neurology 2015 15:54

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  14. Content type: Research article

    Impaired dominant hand function in stroke patients is a common clinical problem. Functional improvement after focal spasticity therapy is well documented but knowledge about central correlates is sparse. Brain...

    Authors: Ulla Bergfeldt, Tomas Jonsson, Lennart Bergfeldt and Per Julin

    Citation: BMC Neurology 2015 15:52

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  15. Content type: Case report

    We describe a case of a very unusual complication following a coiling procedure in which the patient developed transient unique cerebral and cerebellar lesions. Lesions were examined not only by magnetic reson...

    Authors: Kentaro Deguchi, Yuko Kawahara, Shoko Deguchi, Nobutoshi Morimoto, Tomoko Kurata, Yoshio Ikeda, Tomotsugu Ichikawa, Koji Tokunaga, Nobuyuki Kawai, Kenji Sugiu and Koji Abe

    Citation: BMC Neurology 2015 15:49

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  16. Content type: Study protocol

    Development of a long-term stroke care plan requires serial assessment of long-term patient function and consideration of caregiver mood. However, to date, few comprehensive cohort studies have included both s...

    Authors: Won Hyuk Chang, Min Kyun Sohn, Jongmin Lee, Deog Young Kim, Sam-Gyu Lee, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, Eun Young Han and Yun-Hee Kim

    Citation: BMC Neurology 2015 15:42

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  17. Content type: Research article

    Although hyperlipidemia is known as a risk factor of stroke, its effects on the outcome are unknown. The aim of the study is to clarify the influences of hyperlipidemia on the stroke early outcome by estimatin...

    Authors: Kazuo Shigematsu, Yoshiyuki Watanabe and Hiromi Nakano

    Citation: BMC Neurology 2015 15:44

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  18. Content type: Research article

    Stroke is the second largest cause of death worldwide. Hypercoagulability is a key feature in ischaemic stroke due to the development of an abnormally dense clot structure but techniques assessing the mechanic...

    Authors: Sophia N Stanford, Ahmed Sabra, Lindsay D’Silva, Matthew Lawrence, Roger HK Morris, Sharon Storton, Martyn Rowan Brown, Vanessa Evans, Karl Hawkins, Phylip Rhodri Williams, Simon J Davidson, Mushtaq Wani, John F Potter and Phillip A Evans

    Citation: BMC Neurology 2015 15:35

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  19. Content type: Study protocol

    Transient ischemic attacks (TIA) are characterized by acute onset focal neurological symptoms and complete recovery within 24 hours. Attacks of nonfocal symptoms not fulfilling the criteria for TIA but lacking...

    Authors: Frank G van Rooij, Anil M Tuladhar, Roy PC Kessels, Sarah E Vermeer, Bozena M Góraj, Peter J Koudstaal, David G Norris, Frank-Erik de Leeuw and Ewoud J van Dijk

    Citation: BMC Neurology 2015 15:36

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  20. Content type: Research article

    Cognitive impairment commonly occurs in the acute phase post-stroke, but may persist with over half of all stroke survivors experiencing some form of long-term cognitive deficit. Recent evidence suggests that ...

    Authors: Lisa Mellon, Linda Brewer, Patricia Hall, Frances Horgan, David Williams and Anne Hickey

    Citation: BMC Neurology 2015 15:31

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  21. Content type: Research article

    Family history (FH) is a risk factor for cardiovascular disease, especially coronary artery disease (CAD). The impact on risk of stroke is less clear. This study investigated young and middle-aged ischemic str...

    Authors: Halvor Øygarden, Annette Fromm, Kristin Modalsli Sand, Geir Egil Eide, Lars Thomassen, Halvor Naess and Ulrike Waje-Andreassen

    Citation: BMC Neurology 2015 15:30

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  22. Content type: Research article

    About 20% of patients with a first ischaemic stroke will experience a new vascular event within the first year. The atherosclerotic burden, an indicator of the extension of atherosclerosis in a patient, has be...

    Authors: Joaquín Serena, Tomás Segura, Jaume Roquer, María García-Gil and José Castillo

    Citation: BMC Neurology 2015 15:28

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  23. Content type: Research article

    The prognostic impact of preadmission use of calcium channel blockers (CCBs) and beta blockers (BBs) on stroke mortality remains unclear. We aimed to examine whether preadmission use of CCBs or BBs was associa...

    Authors: Jens Sundbøll, Morten Schmidt, Erzsébet Horváth-Puhó, Christian F Christiansen, Lars Pedersen, Hans Erik Bøtker and Henrik T Sørensen

    Citation: BMC Neurology 2015 15:24

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  24. Content type: Research article

    Subarachnoid hemorrhage caused by a ruptured intracranial aneurysm (RIA) is a devastating condition with significant morbidity and mortality. Despite the fact that RIAs can be prevented by microsurgical clippi...

    Authors: Jing Xu, Feiqiang Ma, Wei Yan, Sen Qiao, Shengquan Xu, Yi Li, Jianhong Luo, Jianmin Zhang and Jinghua Jin

    Citation: BMC Neurology 2015 15:23

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  25. Content type: Research article

    The NINDS-Canadian Stroke Network (NINDS-CSN) recommended a neuropsychological battery of three protocols to diagnose vascular cognitive impairment (VCI), however, due to culture and language differences, the ...

    Authors: Xiangliang Chen, Adrian Wong, Ruidong Ye, Lulu Xiao, Zhaojun Wang, Ying Lin, Fang Yang, Hua Li, Ting Feng, Lihui Duan, Yunfei Han, Qiliang Dai, Juan Du, Gelin Xu, Vincent Mok, Yunyun Xiong…

    Citation: BMC Neurology 2015 15:20

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  26. Content type: Research article

    Improvements in stroke management have led to increases in the numbers of stroke survivors over the last decade and there has been a corresponding increase of hospital readmissions after an initial stroke hosp...

    Authors: James Lewsey, Osaretin Ebueku, Pardeep S Jhund, Michelle Gillies, Jim WT Chalmers, Adam Redpath, Andrew Briggs, Matthew Walters, Peter Langhorne, Simon Capewell, John JV McMurray and Kate MacIntyre

    Citation: BMC Neurology 2015 15:3

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  27. Content type: Research article

    Stroke causes lasting disability and the burden of stroke is expected to increase substantially during the next decades. Optimal rehabilitation is therefore mandatory. Early supported discharge (ESD) has previ...

    Authors: Håkon Hofstad, Bente Elisabeth Bassøe Gjelsvik, Halvor Næss, Geir Egil Eide and Jan Sture Skouen

    Citation: BMC Neurology 2014 14:239

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  28. Content type: Research article

    While previous meta-analysis have investigated the efficacy of cilostazol in the secondary prevention of ischemic stroke, they were criticized for their methodology, which confused the acute and chronic phases...

    Authors: LiGen Shi, JiaLi Pu, Liang Xu, Jay Malaguit, Jianmin Zhang and Sheng Chen

    Citation: BMC Neurology 2014 14:251

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  29. Content type: Case report

    Structural anomaly of the cervical spine or craniocervical junction has been reported as one of the rare causes of ischemic stroke. We report a case of a young patient with recurrent posterior circulation infa...

    Authors: Seung-Hoon Song, Hong Gee Roh, Hahn Young Kim, Jin Woo Choi, Won-Jin Moon, Woo Jin Choe and Ileok Jung

    Citation: BMC Neurology 2014 14:252

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  30. Content type: Research article

    Recovering useful hand function after stroke is a major scientific challenge for patients with limited motor recovery. We hypothesized that sequential training beginning with proximal bilateral followed by uni...

    Authors: Sandy McCombe Waller, Jill Whitall, Toye Jenkins, Laurence S Magder, Daniel F Hanley, Andrew Goldberg and Andreas R Luft

    Citation: BMC Neurology 2014 14:236

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  31. Content type: Research article

    Fatigue is common in stroke survivors. Lesion location may influence the risk of poststroke fatigue (PSF) but it is uncertain whether location has an impact on the prognosis of PSF. This study examined the ass...

    Authors: Wai Kwong Tang, Yang Kun Chen, Hua Jun Liang, Winnie Chiu Wing Chu, Vincent Chung Tony Mok, Gabor S Ungvari and Ka Sing Wong

    Citation: BMC Neurology 2014 14:234

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  32. Content type: Research article

    Although it is preferable that all patients with a recent Transient Ischemic Attack (TIA) undergo acute carotid imaging, there are centers with limited access to such acute examinations. It is controversial wh...

    Authors: Elias Johansson, Jakob Bjellerup and Per Wester

    Citation: BMC Neurology 2014 14:223

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  33. Content type: Research article

    Vascular cognitive impairment-no dementia (VCIND) refers to the early or mild cognitive impairment induced by cerebral vascular injury. Research shows that serum total homocysteine (tHcy) level is an independe...

    Authors: Bo Jiang, Yumei Chen, Guoen Yao, Cunshan Yao, Hongmei Zhao, Xiangdong Jia, Yunyan Zhang, Junling Ge, Enchao Qiu and Chengyun Ding

    Citation: BMC Neurology 2014 14:217

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  34. Content type: Research article

    Acute ischemic stroke (AIS) is one of the leading causes of death and adult disability worldwide. In the present study, we aimed to develop a web-based risk model for predicting dynamic functional status at di...

    Authors: Ruijun Ji, Wanliang Du, Haipeng Shen, Yuesong Pan, Penglian Wang, Gaifen Liu, Yilong Wang, Hao Li, Xingquan Zhao and Yongjun Wang

    Citation: BMC Neurology 2014 14:214

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  35. Content type: Case report

    The specificity of computed tomography (CT) for subarachnoid haemorrhage (SAH) is very high. However, physicians should be aware of rare false positive findings, also referred to as "pseudo-SAH". We present an...

    Authors: Maximilian Patzig, Christoph Laub, Hendrik Janssen, Lorenz Ertl and Gunther Fesl

    Citation: BMC Neurology 2014 14:219

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  36. Content type: Study protocol

    10-40% of patients with acute ischemic stroke (AIS) suffer an early neurological deterioration (END), which may influence their long term prognosis. Multiple definitions of END exist, even in recently publishe...

    Authors: Bernt Harald Helleberg, Hanne Ellekjær, Gitta Rohweder and Bent Indredavik

    Citation: BMC Neurology 2014 14:201

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  37. Content type: Research article

    Fatigue, slowness, apathy and decrease in level of activity are common long-term complaints after a subarachnoid haemorrhage (SAH). They resemble the symptoms frequently found in patients with endocrine dysfun...

    Authors: Ladbon Khajeh, Karin Blijdorp, Sebastian JCMM Neggers, Gerard M Ribbers, Diederik WJ Dippel and Fop van Kooten

    Citation: BMC Neurology 2014 14:205

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  38. Content type: Study protocol

    Following stroke, many people have difficulty activating their paretic muscles quickly and with sufficient power to regain their balance by taking quick and effective steps. Reduced dynamic balance and mobilit...

    Authors: Kimberly J Miller, Michael A Hunt, Courtney L Pollock, Dianne Bryant and S Jayne Garland

    Citation: BMC Neurology 2014 14:187

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  39. Content type: Study protocol

    The choice of surgical or conservative treatment for patients with spontaneous intracerebral hemorrhage is controversial. Some minimally invasive treatments have been applied to hematoma evacuation and could i...

    Authors: Jun Zheng, Hao Li, Rui Guo, Sen Lin, Xin Hu, Wei Dong, Lu Ma, Yuan Fang, Anqi Xiao, Ming Liu and Chao You

    Citation: BMC Neurology 2014 14:206

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  40. Content type: Research article

    Cardioembolic stroke (CES) due to atrial fibrillation (AF) is associated with high stroke mortality. Oral anticoagulation (OAC) reduces stroke mortality, however, the impact of OAC-administration during hospit...

    Authors: Frederick Palm, Martin Kraus, Anton Safer, Joachim Wolf, Heiko Becher and Armin J Grau

    Citation: BMC Neurology 2014 14:199

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  41. Content type: Research article

    Mood disorders are commonly seen in those with cerebrovascular disease. Literature to-date has tended to focus on depression and on patients with stroke, with relatively little known about post-stroke anxiety ...

    Authors: Niall M Broomfield, Terence J Quinn, Azmil H Abdul-Rahim, Matthew R Walters and Jonathan J Evans

    Citation: BMC Neurology 2014 14:198

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  42. Content type: Research article

    Despite clear evidence for the effectiveness of oral anticoagulation (OA) in patients with atrial fibrillation (AF), there is evidence for the underutilisation of this therapy in the secondary stroke preventio...

    Authors: Christian Tanislav, Sonja Milde, Sabine Schwartzkopff, Nicole Sieweke, Heidrun Helga Krämer, Martin Juenemann, Björn Misselwitz and Manfred Kaps

    Citation: BMC Neurology 2014 14:195

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  43. Content type: Research article

    In experimental studies, the apolipoprotein D (APOD) and the sigma receptor type 1 (SIGMAR1) have been related to processes of brain damage, repair and plasticity.

    Authors: Håkan Lövkvist, Ann-Cathrin Jönsson, Holger Luthman, Katarina Jood, Christina Jern, Tadeusz Wieloch and Arne Lindgren

    Citation: BMC Neurology 2014 14:191

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  44. Content type: Study protocol

    Novel virtual reality rehabilitation systems provide the potential to increase intensity and offer challenging and motivating tasks. The efficacy of virtual reality systems to improve arm motor function early ...

    Authors: Iris Brunner, Jan S Skouen, Håkon Hofstad, Liv I Strand, Frank Becker, Anne-Marthe Sanders, Hanne Pallesen, Tove Kristensen, Marc Michielsen and Geert Verheyden

    Citation: BMC Neurology 2014 14:186

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  45. Content type: Case report

    Reports of occurrence of deep vein thrombosis during intensive sport are scarce. While a few cases have been described in the cerebral territory, these are only in the context of traumatism or anabolic agent c...

    Authors: Sébastien Richard, Jean-Christophe Lacour, Birgit Frotscher, Ana Enea, Gioia Mione and Xavier Ducrocq

    Citation: BMC Neurology 2014 14:182

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  46. Content type: Research article

    The investigation of glycated hemoglobin (HbA1c) as a diagnostic tool for abnormal glycometabolism is lack in acute ischemic stroke patients in China and worldwide. This paper was aimed to determine whether Hb...

    Authors: Shuolin Wu, Yuzhi Shi, Yuesong Pan, Jingjing Li, Qian Jia, Ning Zhang, Xingquan Zhao, Gaifen Liu, Yilong Wang, Yongjun Wang and Chunxue Wang

    Citation: BMC Neurology 2014 14:177

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