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Cerebrovascular disease and stroke

Section edited by Erwin Stolz and Szatmari Szabolcs

This section is dedicated to covering all aspects of stroke and cerebrovascular diseases. Topics of interest include, but are not limited to, ischemic stroke, spontaneous intracranial bleeding, sinus thrombosis, carotid or vertebral artery disease, cerebrovascular physiology, and neuroimaging related to cerebrovascular diseases.

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  1. Content type: Research article

    Delivery of therapeutic agents as erythropoietin (EPO) into Central Nervous System through intranasal route could benefit patients with neurological disorders. A new nasal formulation containing a non-hematopo...

    Authors: Orestes Santos-Morales, Alina Díaz-Machado, Daise Jiménez-Rodríguez, Yaisel Pomares-Iturralde, Tatiana Festary-Casanovas, Carlos A. González-Delgado, Sonia Pérez-Rodríguez, Eulalia Alfonso-Muñoz, Carmen Viada-González, Patricia Piedra-Sierra, Idrian García-García, Daniel Amaro-González, Julio César García-Rodríguez, Iliana Sosa-Testé, Alicia Lagarto-Parra, Laura Barrero-Viera…

    Citation: BMC Neurology 2017 17:129

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  2. Content type: Case report

    Vitamin K inhibitors (e.g. warfarin) and indirect thrombin inhibitors (e.g. heparin) are widely used to prevent thromboembolic disorders (e.g. myocardial infarction, venous thromboembolism, and stroke). These ...

    Authors: Hyun Goo Kang, Seung Jae Lee, Ji Yeon Chung and Jin Sung Cheong

    Citation: BMC Neurology 2017 17:124

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  3. Content type: Database

    Although International Classification of Disease, Ninth Revision, Clinical Modification (ICD9-CM) coding is the basis of administrative claims data, no study has validated an ICD9-CM algorithm to identify patient...

    Authors: Hormuzdiyar H. Dasenbrock, David J. Cote, Yuri Pompeu, Viren S. Vasudeva, Timothy R. Smith and William B. Gormley

    Citation: BMC Neurology 2017 17:121

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  4. Content type: Research article

    Accumulating evidence has shown that cigarette smoking is an important risk factor for ischemic stroke. However, it is not clear about the potential mechanisms through which cigarette smoking affects stroke ri...

    Authors: Ruijun Ji, Yuesong Pan, Hongyi Yan, Runhua Zhang, Gaifen Liu, Penglian Wang, Yilong Wang, Hao Li, Xingquan Zhao and Yongjun Wang

    Citation: BMC Neurology 2017 17:120

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  5. Content type: Study protocol

    For some stroke patients and caregivers, navigating the transition between hospital discharge and returning home is associated with substantial psychosocial and health-related challenges. Currently, no evidenc...

    Authors: Mathew J. Reeves, Anne K. Hughes, Amanda T. Woodward, Paul P. Freddolino, Constantinos K. Coursaris, Sarah J. Swierenga, Lee H. Schwamm and Michele C. Fritz

    Citation: BMC Neurology 2017 17:115

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  6. Content type: Research article

    Diabetes mellitus (DM) is a risk factor for early neurological deterioration (END) in acute ischemic stroke. The prothrombotic protein fibrinogen is frequently elevated in patients with diabetes, and may be as...

    Authors: Seong-Joon Lee, Ji Man Hong, Sung Eun Lee, Dae Ryong Kang, Bruce Ovbiagele, Andrew M. Demchuk and Jin Soo Lee

    Citation: BMC Neurology 2017 17:101

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  7. Content type: Study protocol

    Aggressively lowering blood pressure (BP) in acute intracerebral hemorrhage (ICH) may improve outcome. Although there is no evidence that BP reduction changes cerebral blood flow, retrospective magnetic resona...

    Authors: Laura Gioia, Ana Klahr, Mahesh Kate, Brian Buck, Dariush Dowlatshahi, Thomas Jeerakathil, Derek Emery and Kenneth Butcher

    Citation: BMC Neurology 2017 17:100

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  8. Content type: Research article

    It is a common belief in medical community that lunar phases have an impact on human health. A growing body of evidence indicates that lunar phases can predict the risk to develop acute neurological and vascul...

    Authors: Adomas Bunevicius, Agne Gendvilaite, Vytenis Pranas Deltuva and Arimantas Tamasauskas

    Citation: BMC Neurology 2017 17:99

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  9. Content type: Research article

    There are contradictory reports concerning the validity of transcranial sonography (TCD and TCCS) for examinations of the basilar artery. Here we investigated sensitivity and specificity of transcranial sonogr...

    Authors: Woori Koh, Kai Kallenberg, André Karch, Tobias Frank, Michael Knauth, Mathias Bähr and Jan Liman

    Citation: BMC Neurology 2017 17:89

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  10. Content type: Case report

    Detailed knowledge of every possible manifestation of Internal Carotid Artery (ICA) disease is important. For improving detection and a timely adoption of secondary prevention procedures or treatments. Transie...

    Authors: José Carlos Morán-Sánchez, Irene Gómez-Estévez, Yasmina El Berdei, José C. Gómez-Sánchez and María E. Ramos-Araque

    Citation: BMC Neurology 2017 17:69

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  11. Content type: Research article

    Post-stroke delirium is a common problem in the care of stroke patients, and is associated with longer hospitalization, high short-term mortality, and an increased need for long-term care. Although post-stroke...

    Authors: Tae Sung Lim, Jin Soo Lee, Jung Han Yoon, So Young Moon, In Soo Joo, Kyoon Huh and Ji Man Hong

    Citation: BMC Neurology 2017 17:56

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  12. Content type: Research article

    Factors influencing access to stroke unit (SU) care and data on quality of SU care in Germany are scarce. We investigated characteristics of patients directly admitted to a SU as well as patient-related and st...

    Authors: Steffi Hillmann, Silke Wiedmann, Viktoria Rücker, Klaus Berger, Darius Nabavi, Ingo Bruder, Hans-Christian Koennecke, Günter Seidel, Björn Misselwitz, Alfred Janssen, Christoph Burmeister, Christine Matthis, Otto Busse, Peter Hermanek and Peter Ulrich Heuschmann

    Citation: BMC Neurology 2017 17:49

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  13. Content type: Research article

    Although the Brain Attack Coalition recommended establishing centers of comprehensive care for stroke and cerebrovascular disease patients, a scoring system for such centers was lacking. We created and validat...

    Authors: Akiko Kada, Kunihiro Nishimura, Jyoji Nakagawara, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Kazunori Toyoda, Shinya Matsuda, Akifumi Suzuki, Hiroharu Kataoka, Fumiaki Nakamura, Satoru Kamitani and Koji Iihara

    Citation: BMC Neurology 2017 17:46

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  14. Content type: Case report

    Stroke is the leading cause of mortality and disability worldwide. Several definite risk factors have been identified for stroke, although infectious factors might also contribute to stroke episodes through in...

    Authors: Kai Shan and Wei Guo

    Citation: BMC Neurology 2017 17:33

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  15. Content type: Study protocol

    Recurrent strokes are preventable through awareness and control of risk factors such as hypertension, and through lifestyle changes such as healthier diets, greater physical activity, and smoking cessation. Ho...

    Authors: Amytis Towfighi, Eric M. Cheng, Monica Ayala-Rivera, Heather McCreath, Nerses Sanossian, Tara Dutta, Bijal Mehta, Robert Bryg, Neal Rao, Shlee Song, Ali Razmara, Magaly Ramirez, Theresa Sivers-Teixeira, Jamie Tran, Elizabeth Mojarro-Huang, Ana Montoya…

    Citation: BMC Neurology 2017 17:24

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  16. Content type: Research article

    Conflicting results on the correlation between hyperuricemia and the prognosis of stroke had been reported and the close association between serum uric acid (SUA) and abnormal glycomatabolism might further com...

    Authors: Shuolin Wu, Yuesong Pan, Ning Zhang, Wang Yong Jun and Chunxue Wang

    Citation: BMC Neurology 2017 17:21

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  17. Content type: Research article

    Increased level of blood viscosity, which is one of the major factors that determine blood rheology, has been reported as a risk factor or predictor for cerebrovascular events. We investigated how blood viscos...

    Authors: Seung Hoon Song, Jeong Hee Kim, Joon Hwa Lee, Yeo-Min Yun, Dong-Hee Choi and Hahn Young Kim

    Citation: BMC Neurology 2017 17:20

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  18. Content type: Research article

    Understanding the gap between evidence-based recommendations and real-world management is important to inform priority setting and health service planning.

    Authors: Giovanni Corrao, Federico Rea, Luca Merlino, Paolo Mazzola, Federico Annoni and Giorgio Annoni

    Citation: BMC Neurology 2017 17:12

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  19. Content type: Research article

    We conducted a prospective cohort study to investigate prevalence of poststroke cognitive impairment at 3 and 12 months after stroke onset and identify clinical and demographic factors associated with improvem...

    Authors: Jin A. Yoon, Deog Young Kim, Min Kyun Sohn, Jongmin Lee, Sam-Gyu Lee, Yang-Soo Lee, Eun Young Han, Min Cheol Joo, Gyung-Jae Oh, Junhee Han, Minsu Park, Kyung Pil Park, Kyung-Ha Noh, Won Hyuk Chang, Yong-Il Shin and Yun-Hee Kim

    Citation: BMC Neurology 2017 17:9

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  20. Content type: Research article

    The underlying pathophysiology of BA distribution is unclear and intriguing. Using high-resolution magnetic resonance imaging (HR-MRI), we sought to explore the plaque distribution of low-grade basilar artery ...

    Authors: Jin Yu, Ming-Li Li, Yu-Yuan Xu, Shi-Wen Wu, Min Lou, Xue-Tao Mu, Feng Feng, Shan Gao and Wei-Hai Xu

    Citation: BMC Neurology 2017 17:8

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  21. Content type: Research article

    There is a link between high on-treatment platelet reactivity (HPR) and adverse vascular events in stroke. This study aimed to compare multiple electrode platelet aggregometry (MEA), in healthy subjects and is...

    Authors: Ahmed Sabra, Sophia N. Stanford, Sharon Storton, Matthew Lawrence, Lindsay D’Silva, Roger H. K. Morris, Vanessa Evans, Mushtaq Wani, John F. Potter and Phillip A. Evans

    Citation: BMC Neurology 2016 16:254

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  22. Content type: Research article

    There is very little information about the quality of life (QOL) of stroke survivors in LMIC countries with underdeveloped non communicable health infrastructures, who bear two thirds of the global stroke burden.

    Authors: Wardah Khalid, Shafquat Rozi, Tazeen Saeed Ali, Iqbal Azam, Michael T. Mullen, Saleem Illyas, Qamar un-Nisa, Nabila Soomro and Ayeesha Kamran Kamal

    Citation: BMC Neurology 2016 16:250

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  23. Content type: Research article

    The health-related quality of life in stroke patients (HRQOLISP-40, short version) survey was developed in Nigeria and constitutes a 40-item, multidimensional, self-administrated questionnaire. We assessed the...

    Authors: Yahira Rossini Guzmán Sabogal, Jorge Pla Vidal, Ricardo Sánchez Pedraza, Felipe Ortuño Sánchez-Pedreño and María Catalina Gómez Guevara

    Citation: BMC Neurology 2016 16:246

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  24. Content type: Research article

    Patients with acute stroke often do not seek immediate medical help, which is assumed to be driven by lack of knowledge of stroke symptoms. We explored the process of help seeking behavior in patients with acu...

    Authors: E. Zock, H. Kerkhoff, R. P. Kleyweg, T. B. V. van Bavel-Ta, S. Scott, N. D. Kruyt, P. J. Nederkoorn and D. van de Beek

    Citation: BMC Neurology 2016 16:241

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  25. Content type: Research article

    High body temperatures after ischemic stroke have been associated with larger infarct size, but the temporal profile of this relation is unknown. We assess the relation between temporal profile of body tempera...

    Authors: Marjolein Geurts, Féline E. V. Scheijmans, Tom van Seeters, Geert J. Biessels, L. Jaap Kappelle, Birgitta K. Velthuis and H. Bart van der Worp

    Citation: BMC Neurology 2016 16:233

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  26. Content type: Case report

    Few previous hemodynamic studies demonstrated the detailed features of rupture point of intracranial aneurysms. The hemodynamic simulation for the case that ruptured during angiography was even rare. In the pr...

    Authors: Yisen Zhang, Linkai Jing, Ying Zhang, Jian Liu and Xinjian Yang

    Citation: BMC Neurology 2016 16:231

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  27. Content type: Case report

    It is clinically rare to find cytomegalovirus (CMV)-associated encephalomyelitis in immunocompetent adults. Here, we present the case of an adult patient who developed acute transverse myelitis that was follow...

    Authors: Kensuke Daida, Yuta Ishiguro, Hiroto Eguchi, Yutaka Machida, Nobutaka Hattori and Hideto Miwa

    Citation: BMC Neurology 2016 16:223

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  28. Content type: Research article

    While the precise timing and intensity of very early rehabilitation (VER) after stroke onset is still under discussion, its beneficial effect on functional disability is generally accepted. The recently publis...

    Authors: Björn Reuter, Christoph Gumbinger, Tamara Sauer, Horst Wiethölter, Ingo Bruder, Curt Diehm, Peter A. Ringleb, Werner Hacke, Michael G. Hennerici and Rolf Kern

    Citation: BMC Neurology 2016 16:222

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  29. Content type: Research article

    A description of the complexity of the process of self-management and the way stroke survivors give meaning to their process of self-management post-stroke is lacking. This study explores how stroke survivors ...

    Authors: Ton Satink, Staffan Josephsson, Jana Zajec, Edith H. C. Cup, Bert J. M. de Swart and Maria W. G. Nijhuis-van der Sanden

    Citation: BMC Neurology 2016 16:221

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  30. Content type: Research article

    Virtual reality (VR) training is thought to improve upper limb (UL) motor function after stroke when utilizing intensive training with many repetitions. The purpose of this study was to compare intensity and c...

    Authors: Iris Brunner, Jan Sture Skouen, Håkon Hofstad, Jörg Aßmuss, Frank Becker, Hanne Pallesen, Liselot Thijs and Geert Verheyden

    Citation: BMC Neurology 2016 16:219

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  31. Content type: Research article

    Despite that disability of the upper extremity is common after stroke, there is limited knowledge how it influences self-perceived ability to perform daily hand activities. The aim of this study was to describ...

    Authors: Elisabeth Ekstrand, Lars Rylander, Jan Lexell and Christina Brogårdh

    Citation: BMC Neurology 2016 16:208

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  32. Content type: Research article

    Acute ischemic stroke (AIS) is a common neurological event that causes varying degrees of disability. AIS outcome varies considerably, from complete recovery to complete loss of tissue and function. This diver...

    Authors: Estelle Seyman, Hilla Shaim, Shani Shenhar-Tsarfaty, Tali Jonash-Kimchi, Natan M. Bornstein and Hen Hallevi

    Citation: BMC Neurology 2016 16:206

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  33. Content type: Research article

    Previous studies suggested the potential interactions between cerebrovascular diseases and impaired renal function. However, the relationship between renal function and white matter hyperintensity (WMH), marke...

    Authors: Lixia Zong, Ming Yao, Jun Ni, Lixin Zhou, Jing Yuan, Bin Peng, Yi-Cheng Zhu and Liying Cui

    Citation: BMC Neurology 2016 16:193

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  34. Content type: Research article

    Hypertension is the prime risk factor for stroke, and primary aldosteronism (PA) is the most common cause of secondary hypertension. The prevalence of PA in stroke patients has never been reported. The aim of ...

    Authors: Yosuke Miyaji, Yuichi Kawabata, Hideto Joki, Shunsuke Seki, Kentaro Mori, Tomoya Kamide, Akira Tamase, Hiroshi Shima, Motohiro Nomura, Yoshihisa Kitamura, Hirotatsu Nakaguchi, Taichi Minami, Tetsuji Tsunoda, Mayuko Sasaki, Masayo Yamada and Fumiaki Tanaka

    Citation: BMC Neurology 2016 16:177

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  35. Content type: Research article

    Early identification of stroke is crucial to maximize early management benefits in emergency departments. This study aimed to develop and validate a new stroke recognition instrument for differentiating acute ...

    Authors: Haifeng Mao, Peiyi Lin, Junrong Mo, Yunmei Li, Xiaohui Chen, Timothy H. Rainer and Huilin Jiang

    Citation: BMC Neurology 2016 16:168

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  36. Content type: Research article

    Exercise testing devices for evaluating cardiopulmonary fitness in patients with severe disability after stroke are lacking, but we have adapted a robotics-assisted tilt table (RATT) for cardiopulmonary exerci...

    Authors: Jittima Saengsuwan, Lucia Berger, Corina Schuster-Amft, Tobias Nef and Kenneth J. Hunt

    Citation: BMC Neurology 2016 16:163

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  37. Content type: Research article

    The underlying causes of minor stroke are difficult to assess. Here, we evaluate the reliability of the Chinese Ischemic Stroke Subclassification (CISS) system in patients with minor stroke, and compare it to ...

    Authors: Sha Tan, Lei Zhang, Xiaoyu Chen, Yanqiang Wang, Yinyao Lin, Wei Cai, Yilong Shan, Wei Qiu, Xueqiang Hu and Zhengqi Lu

    Citation: BMC Neurology 2016 16:162

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  38. Content type: Research article

    Ischemic stroke is the main cause of mortality and disability in older people worldwide. Recently epidemiological studies indicate that ischemic stroke is a complex disorder with a strong genetic component. Ge...

    Authors: Xiaoming Ling, Yansong Zheng, Jing Tao, Zhezhou Zheng and Lidian Chen

    Citation: BMC Neurology 2016 16:146

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  39. Content type: Research article

    VE-cadherin is the chief constituent of endothelial adherens junctions. However, the role of VE-cadherin in the pathogenesis of cerebrovascular diseases including brain ischemia has not yet been investigated.

    Authors: Karen Gertz, Golo Kronenberg, Ria Uhlemann, Vincent Prinz, Ruben Marquina, Monica Corada, Elisabetta Dejana and Matthias Endres

    Citation: BMC Neurology 2016 16:144

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  40. Content type: Research article

    In general people after stroke do not meet the recommendations for physical activity to conduct a healthy lifestyle. Programs to stimulate walking activity to increase physical activity are based on the availa...

    Authors: Jacqueline Outermans, Jan Pool, Ingrid van de Port, Japie Bakers and Harriet Wittink

    Citation: BMC Neurology 2016 16:137

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  41. Content type: Case report

    Magnesium has a regulatory role in the excitability of cell membranes, and is also a cofactor in the phosphorylation of thiamine. Hypomagnesemia has been associated with coronary vasospasm, but its role in cer...

    Authors: Álvaro Sánchez-Larsen, Tomás Segura, Susana García-Muñozguren, Javier Peinado-Ródenas, Joaquín Zamarro and Francisco Hernández-Fernández

    Citation: BMC Neurology 2016 16:135

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  42. Content type: Research article

    Complications after stroke have been associated with poor outcome. Modern stroke treatment might reduce the occurrence of complications. The aim of this study was to investigate whether the frequency and type ...

    Authors: Martina Reiten Bovim, Torunn Askim, Stian Lydersen, Hild Fjærtoft and Bent Indredavik

    Citation: BMC Neurology 2016 16:133

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